Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007042209> ?p ?o ?g. }
- W2007042209 endingPage "1596" @default.
- W2007042209 startingPage "1586" @default.
- W2007042209 abstract "The genomes of bacterial and viral DNA contain a much higher frequency of unmethylated CpG dinucleotides than those of vertebrates. This difference in genome structure allows the innate immune system of vertebrates to distinguish bacterial or viral DNA from self-DNA, and consequently to perceive a ‘danger signal’ when bacterial or viral DNA is encountered. Multiple sources of evidence suggest that CpG motifs, including bacterial DNA and CpG ODNs (synthetic oligodeoxynucleotides containing unmethylated CpG), are capable of evoking a range of immunostimulatory effects in vertebrates and have a tremendous potential to be used as therapeutic agents and adjuvants. CpG motifs with different sequences have been shown to induce various types or levels of immunostimulatory responses whereas the immunostimulatory effects of CpG motifs are species-specific. A better understanding of CpG recognition at the molecular level is fundamental to the identification of those motifs that have desired immunostimulatory responses. It is hoped that this would allow the optimization and application of CpG motifs as therapeutic agents and adjuvants, for numerous diseases in various species." @default.
- W2007042209 created "2016-06-24" @default.
- W2007042209 creator A5010108675 @default.
- W2007042209 date "2006-10-01" @default.
- W2007042209 modified "2023-10-11" @default.
- W2007042209 title "CpG oligodeoxynucleotides as DNA adjuvants in vertebrates and their applications in immunotherapy" @default.
- W2007042209 cites W1514540900 @default.
- W2007042209 cites W1538844879 @default.
- W2007042209 cites W1669974101 @default.
- W2007042209 cites W1671075316 @default.
- W2007042209 cites W1963810035 @default.
- W2007042209 cites W1967084054 @default.
- W2007042209 cites W1970610688 @default.
- W2007042209 cites W1975396221 @default.
- W2007042209 cites W1988160732 @default.
- W2007042209 cites W1988560142 @default.
- W2007042209 cites W1988711597 @default.
- W2007042209 cites W1989302754 @default.
- W2007042209 cites W1994306951 @default.
- W2007042209 cites W1995266489 @default.
- W2007042209 cites W2001062496 @default.
- W2007042209 cites W2001356425 @default.
- W2007042209 cites W2011687160 @default.
- W2007042209 cites W2022869355 @default.
- W2007042209 cites W2025345914 @default.
- W2007042209 cites W2026878760 @default.
- W2007042209 cites W2027254513 @default.
- W2007042209 cites W2027404973 @default.
- W2007042209 cites W2028051260 @default.
- W2007042209 cites W2030506606 @default.
- W2007042209 cites W2032630870 @default.
- W2007042209 cites W2033063638 @default.
- W2007042209 cites W2033148258 @default.
- W2007042209 cites W2036799823 @default.
- W2007042209 cites W2038168418 @default.
- W2007042209 cites W2038308319 @default.
- W2007042209 cites W2041219756 @default.
- W2007042209 cites W2047110135 @default.
- W2007042209 cites W2047366876 @default.
- W2007042209 cites W2048570541 @default.
- W2007042209 cites W2053387521 @default.
- W2007042209 cites W2058649253 @default.
- W2007042209 cites W2063128111 @default.
- W2007042209 cites W2063338440 @default.
- W2007042209 cites W2065193095 @default.
- W2007042209 cites W2068515672 @default.
- W2007042209 cites W2069981713 @default.
- W2007042209 cites W2072780211 @default.
- W2007042209 cites W2073746638 @default.
- W2007042209 cites W2074871929 @default.
- W2007042209 cites W2082537000 @default.
- W2007042209 cites W2082636822 @default.
- W2007042209 cites W2085428764 @default.
- W2007042209 cites W2087144130 @default.
- W2007042209 cites W2089580397 @default.
- W2007042209 cites W2091905924 @default.
- W2007042209 cites W2092128665 @default.
- W2007042209 cites W2097884047 @default.
- W2007042209 cites W2099214157 @default.
- W2007042209 cites W2118011548 @default.
- W2007042209 cites W2131326178 @default.
- W2007042209 cites W2148704093 @default.
- W2007042209 cites W2151809081 @default.
- W2007042209 cites W2163866482 @default.
- W2007042209 cites W2170275869 @default.
- W2007042209 cites W2178846731 @default.
- W2007042209 cites W2332423443 @default.
- W2007042209 cites W4249935589 @default.
- W2007042209 cites W4312782897 @default.
- W2007042209 cites W4313422262 @default.
- W2007042209 doi "https://doi.org/10.1016/j.intimp.2006.06.001" @default.
- W2007042209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16919831" @default.
- W2007042209 hasPublicationYear "2006" @default.
- W2007042209 type Work @default.
- W2007042209 sameAs 2007042209 @default.
- W2007042209 citedByCount "32" @default.
- W2007042209 countsByYear W20070422092012 @default.
- W2007042209 countsByYear W20070422092013 @default.
- W2007042209 countsByYear W20070422092014 @default.
- W2007042209 countsByYear W20070422092015 @default.
- W2007042209 countsByYear W20070422092016 @default.
- W2007042209 countsByYear W20070422092017 @default.
- W2007042209 countsByYear W20070422092018 @default.
- W2007042209 countsByYear W20070422092019 @default.
- W2007042209 countsByYear W20070422092020 @default.
- W2007042209 countsByYear W20070422092021 @default.
- W2007042209 countsByYear W20070422092022 @default.
- W2007042209 crossrefType "journal-article" @default.
- W2007042209 hasAuthorship W2007042209A5010108675 @default.
- W2007042209 hasConcept C104317684 @default.
- W2007042209 hasConcept C136449434 @default.
- W2007042209 hasConcept C140173407 @default.
- W2007042209 hasConcept C141231307 @default.
- W2007042209 hasConcept C150194340 @default.
- W2007042209 hasConcept C190727270 @default.
- W2007042209 hasConcept C22801619 @default.
- W2007042209 hasConcept C54355233 @default.
- W2007042209 hasConcept C552990157 @default.