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• W2007048372 abstract "Abstract Several GTP‐binding protein (G‐protein)–coupled receptors that signal through Gαs (GTP‐binding protein α stimulatory) and the cyclic adenosine monophosphate (cAMP) pathway increase skeletal muscle mass. In order to further evaluate the role of the cAMP pathway in the regulation of skeletal muscle mass, we utilized inhibitors of phosphodiesterase 4 (PDE 4), the major cAMP‐modifying PDE found in skeletal muscle, to modulate skeletal muscle cAMP levels. We found that PDE 4 inhibitors reduced the loss of muscle mass and force resulting from denervation and casting in rats and mice. These studies indicate that PDE 4 inhibitors may have a role in the treatment of skeletal muscle–wasting diseases. Muscle Nerve, 2005" @default.
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• W2007048372 date "2005-08-22" @default.
• W2007048372 modified "2023-10-11" @default.
• W2007048372 title "Phosphodiesterase 4 inhibition reduces skeletal muscle atrophy" @default.
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• W2007048372 doi "https://doi.org/10.1002/mus.20416" @default.
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