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- W2007049746 abstract "RUNX1 is a transcription factor that plays critical roles in hematopoietic proliferation and differentiation. Megakaryocyte is a precursor cell of platelets. Several reports have implied that RUNX1 is important in megakaryocytic differentiation and proliferation. However, the mechanism is not well understood. In this study, we employed a megakaryocytic cell line UT-7/GM and suppressed the RUNX1 gene expression by siRNA. Knocking down of RUNX1 induced the increase of megakaryocyte-specific gene expression and down-regulation of polyploidization. RUNX1 overexpression decreased the PF4 and GPIIb promoter activities. These results suggest that RUNX1 promotes proliferation of megakaryocytic cell line but not megakaryocytic gene expression in UT-7/GM cells." @default.
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- W2007049746 date "2006-11-01" @default.
- W2007049746 modified "2023-10-16" @default.
- W2007049746 title "Suppression of RUNX1 by siRNA in megakaryocytic UT-7/GM cells" @default.
- W2007049746 doi "https://doi.org/10.1093/nass/nrl130" @default.
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