Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007050337> ?p ?o ?g. }
- W2007050337 endingPage "424" @default.
- W2007050337 startingPage "417" @default.
- W2007050337 abstract "SUMMARY We have examined alterations in all of the major splenic mononuclear cell (SMNC) populations in C57Bl/6 mice following whole-body irradiation (0–700 cGy) in order to determine which populations may play a role in active immune suppression and/or haematopoietic recovery. A protocol has been established for characterization and differentiation by flow cytometric analysis (FCA) of the major MNC populations in the mouse spleen: T lymphocytes (CD4+ and CD8+ cells), B lymphocytes, natural killer (NK) cells, and monocytes/macrophages. Ionizing radiation caused decreased spleen cellularity and decreased ability of surviving SMNC to respond to mitogen. FCA revealed alterations in the relative composition of the constituent splenic cell populations following irradiation, reflecting differential radiosensitivity, with selective enrichment of NK cells (seven-fold) and CD4+ T lymphocytes (three-fold). Enrichment developed during the 7-day post-irradiation period. In addition, some MNC became activated in a dose- and time-dependent fashion following whole-body irradiation, as indicated by expression of CD71, the transferrin receptor. These cells were CD34+ and Thy1.2+, but were CD4− or CD8− as well as CD45− (B cell). The observed increase in NK cells corresponds with a previously reported increase in natural suppressor (NS) cells following total-lymphoid irradiation (TLI). The balance of recovery-inhibiting NK cells and recovery-enhancing CD4+ T lymphocytes following irradiation may reflect or influence the degree of haematopoietic recovery, and may provide an indication of the extent of damage (biological dosimetry)." @default.
- W2007050337 created "2016-06-24" @default.
- W2007050337 creator A5015240437 @default.
- W2007050337 creator A5021063023 @default.
- W2007050337 creator A5041374355 @default.
- W2007050337 creator A5048152542 @default.
- W2007050337 date "1997-02-01" @default.
- W2007050337 modified "2023-10-14" @default.
- W2007050337 title "Radiation damage and immune suppression in splenic mononuclear cell populations" @default.
- W2007050337 cites W102933687 @default.
- W2007050337 cites W118374061 @default.
- W2007050337 cites W1526617084 @default.
- W2007050337 cites W1548632485 @default.
- W2007050337 cites W1550160699 @default.
- W2007050337 cites W1561523291 @default.
- W2007050337 cites W1591535972 @default.
- W2007050337 cites W1601971860 @default.
- W2007050337 cites W1618233672 @default.
- W2007050337 cites W186797036 @default.
- W2007050337 cites W19113743 @default.
- W2007050337 cites W1920473099 @default.
- W2007050337 cites W1965302409 @default.
- W2007050337 cites W1966139611 @default.
- W2007050337 cites W1973915978 @default.
- W2007050337 cites W1976914763 @default.
- W2007050337 cites W1980924499 @default.
- W2007050337 cites W1987551665 @default.
- W2007050337 cites W1999715144 @default.
- W2007050337 cites W2003193415 @default.
- W2007050337 cites W2010138493 @default.
- W2007050337 cites W2012739094 @default.
- W2007050337 cites W2027255721 @default.
- W2007050337 cites W2029141965 @default.
- W2007050337 cites W2032464886 @default.
- W2007050337 cites W2042680479 @default.
- W2007050337 cites W2047243294 @default.
- W2007050337 cites W2049621363 @default.
- W2007050337 cites W2070889544 @default.
- W2007050337 cites W2079116948 @default.
- W2007050337 cites W2080883834 @default.
- W2007050337 cites W2086793358 @default.
- W2007050337 cites W2097581372 @default.
- W2007050337 cites W211697509 @default.
- W2007050337 cites W2118500907 @default.
- W2007050337 cites W2172845396 @default.
- W2007050337 cites W2288814111 @default.
- W2007050337 cites W2362133934 @default.
- W2007050337 cites W2425803545 @default.
- W2007050337 cites W2428348270 @default.
- W2007050337 cites W2443220535 @default.
- W2007050337 cites W2472971247 @default.
- W2007050337 cites W2587817062 @default.
- W2007050337 cites W293873734 @default.
- W2007050337 cites W159317543 @default.
- W2007050337 doi "https://doi.org/10.1111/j.1365-2249.1997.272-ce1158.x" @default.
- W2007050337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1904575" @default.
- W2007050337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9030884" @default.
- W2007050337 hasPublicationYear "1997" @default.
- W2007050337 type Work @default.
- W2007050337 sameAs 2007050337 @default.
- W2007050337 citedByCount "68" @default.
- W2007050337 countsByYear W20070503372012 @default.
- W2007050337 countsByYear W20070503372013 @default.
- W2007050337 countsByYear W20070503372014 @default.
- W2007050337 countsByYear W20070503372015 @default.
- W2007050337 countsByYear W20070503372016 @default.
- W2007050337 countsByYear W20070503372017 @default.
- W2007050337 countsByYear W20070503372018 @default.
- W2007050337 countsByYear W20070503372019 @default.
- W2007050337 countsByYear W20070503372020 @default.
- W2007050337 countsByYear W20070503372021 @default.
- W2007050337 countsByYear W20070503372022 @default.
- W2007050337 countsByYear W20070503372023 @default.
- W2007050337 crossrefType "journal-article" @default.
- W2007050337 hasAuthorship W2007050337A5015240437 @default.
- W2007050337 hasAuthorship W2007050337A5021063023 @default.
- W2007050337 hasAuthorship W2007050337A5041374355 @default.
- W2007050337 hasAuthorship W2007050337A5048152542 @default.
- W2007050337 hasBestOaLocation W20070503371 @default.
- W2007050337 hasConcept C109159458 @default.
- W2007050337 hasConcept C126322002 @default.
- W2007050337 hasConcept C137061746 @default.
- W2007050337 hasConcept C153911025 @default.
- W2007050337 hasConcept C154317977 @default.
- W2007050337 hasConcept C167672396 @default.
- W2007050337 hasConcept C202751555 @default.
- W2007050337 hasConcept C203014093 @default.
- W2007050337 hasConcept C206684579 @default.
- W2007050337 hasConcept C2778102761 @default.
- W2007050337 hasConcept C2780931953 @default.
- W2007050337 hasConcept C28328180 @default.
- W2007050337 hasConcept C509974204 @default.
- W2007050337 hasConcept C55493867 @default.
- W2007050337 hasConcept C71924100 @default.
- W2007050337 hasConcept C86803240 @default.
- W2007050337 hasConcept C8891405 @default.
- W2007050337 hasConcept C95444343 @default.
- W2007050337 hasConceptScore W2007050337C109159458 @default.