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• W2007059197 abstract "Article1 April 1962A Therapeutic DilemmaThe Treatment of Disseminated Coccidioidomycosis with Amphotericin BWILLIAM G. SANFORD, JAMES R. RASCH, ROBERT B. STONEHILLWILLIAM G. SANFORDSearch for more papers by this author, JAMES R. RASCHSearch for more papers by this author, ROBERT B. STONEHILLSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-553 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExcept in its disseminated form, coccidioidomycosis is a benign pulmonary disorder which is endemic in the southwestern part of the United States. The disseminated or progressive primary form has a fatality rate of more than 50% and requires vigorous, if not heroic, treatment (1). Although amphotericin B is relatively toxic, it has become recognized as the most effective antifungal agent for this disorder. The occurrence of transient azotemia has been reported repeatedly with amphotericin B. However, with relatively low dosages, permanent renal damage has not been reported generally. The experience at the USAF Hospital Lackland with six cases of disseminated...References1. WINN WA: The use of amphotericin B in the treatment of coccidioidal disease. Amer. J. Med. 27: 617, 1959. CrossrefMedlineGoogle Scholar2. LOURIA DB: Some aspects of the absorption, distribution, and excretion of amphotericin B in man. Antibiot. Med. 5: 295, 1958. Google Scholar3. HARRELLBOCABO ERFC: Modern treatment of the systemic fungus diseases. Clin. Pharmacol. Ther. 1: 104, 1960. CrossrefGoogle Scholar4. LITTMANHOROWITZSWADEY MDPLJG: Coccidioidomycosis and its treatment with amphotericin B. Amer. J. Med. 24: 568, 1958. CrossrefMedlineGoogle Scholar5. PERRYKIRBY DMWM: Acute disseminated coccidioidomycosis: two cases treated with amphotericin B. Arch. Intern. Med. 105: 929, 1960. CrossrefMedlineGoogle Scholar6. COLWELL JA: Remission in disseminated coccidioidomycosis produced by amphotericin B. Ann. Intern. Med. 50: 1028, 1959. LinkGoogle Scholar7. HUNTERMONGAN RCES: Disseminated coccidioidomycosis treated with amphotericin B. U. S. Armed Forces Med. J. 9: 1474, 1958. MedlineGoogle Scholar8. SMITHSAITOSIMONS CEMTSA: Pattern of 39,500 serologic tests in coccidioidomycosis. J. A. M. A. 160: 546, 1956. CrossrefMedlineGoogle Scholar9. SMITHSAITOBEARDKEPPCLARKEDDIE CEMTRRRMRWBV: Serologic tests in diagnosis and prognosis of coccidioidomycosis. Amer. J. Hyg. 52: 1, 1950. MedlineGoogle Scholar10. RHOADESGINNMUCHMORESMITHHAMMARSTEN ERHEHGWOJF: Effect of amphotericin B upon renal function in man. Clin. Research 8: 232, 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Department of Medicine, USAF Aerospace Medical Center, Lackland Air Force Base, Texas.This paper represents the personal viewpoint of the authors and is not to be construed as a statement of official Air Force policy.Requests for reprints should be addressed to Captain James R. Rasch, USAF (MC), USAF Hospital Lackland, USAF Aerospace Medical Center (AFSC), Lackland Air Force Base, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrugs influencing acid base balance and bicarbonate concentration readingsPneumocystis and Other Less Common Fungal InfectionsPneumocystis and Other Less Common Fungal InfectionsNovel modes of antifungal drug administrationAmphotericin B severely affects expression and activity of the endothelial constitutive nitric oxide synthase involving altered mRNA stabilityClinical Significance of Nephrotoxicity in Patients Treated with Amphotericin B for Suspected or Proven AspergillosisTreatment of CoccidioidomycosisAntimycotic therapy: A critical appraisalLong-term outpatient amphotericin B therapy via a silicone central alimentation catheterCoccidioidomycosis: Evaluation of parameters used to predict outcome with amphotericin B therapyPulmonary CoccidioidomycosisOperative management of chronic coccidioidomycosisHypercalcemia in Disseminated CoccidioidomycosisBlastomyces dermatitidis treated during pregnancy: Report of a caseUniform Susceptibility of Various Strains of Coccidioides immitis to Amphotericin BNephrotoxic effect of 2‐aminoanthraquinone in fischer ratsIn Vitro Inhibition of Coccidioides Immitis Strains with Amphotericin B Plus RifampinTreatment of infective endocarditis—1973Immunologic and clinical improvement of progressive coccidioidomycosis following administration of transfer factorAmphotericin B usage in pregnancy complicated by cryptococcosisNephrotoxicity of amphotericin B, with emphasis on changes in tubular functionOsseous sporotrichosisHypokalemic Myopathy Induced by Amphotericin BCoccidioidomycosisCoccidioidomycosisOral amphotericin B in the treatment of ulcerative intestinal diseasesCoccidoidal meningitisChronic Pulmonary CoccidioidomycosisAmphotericin B Toxicity A Follow-up Report of 53 PatientsRAYMOND P. MILLER, M.D., JOSEPH H. BATES, M.D., F.A.C.P.Amphotericin B therapy in childrenDie CoccidioidomykoseDie HistoplasmoseNephrotoxic effects of amphotericin B, including renal tubular acidosisCryptococcosis: Current statusRenal Tubular Acidosis Due to Amphotericin BAlternate-Day Amphotericin B Therapy in the Treatment of Rhinocerebral Phycomycosis (Mucormycosis)DENNIS J. BATTOCK, M.D., HENRY GRAUSZ, M.D., MARTIN BOBROWSKY, M.D., MAXWELL L. LITTMAN, M.D., PH.D.The Significance of CandidemiaCHARLES A. ELLIS, M.D., MARTIN L. SPIVACK, M.D., PH.D.Toxic nephropathyComplications associated with antibiotic therapyNephrotoxicity of Amphotericin B Early and Late Effects in 81 PatientsWILLIAM T. BUTLER, M.D., JOHN E. BENNETT, M.D., DAVID W. ALLING, M.D., PH.D., PAUL T. WERTLAKE, M.D., JOHN P. UTZ, M.D., GEORGE J. HILL II, M.D.Changes in Renal FunctionWILLIAM T. BUTLER, M.D.Changes in Renal MorphologyGEORGE J. HILL II, M.D.CRYPTOCOCCOSIS (TORULOSIS) : SOME PROBLEMS IN DIAGNOSIS AND MANAGEMENTQuadriplegia Caused by Involvement of Cervical Spine with Coccidioides immitisAmphotericin B Nephrotoxicity with Irreversible Renal FailureFRANK J. TAKACS, M.D., ZYGMUNT M. TOMKIEWICZ, M.D., JOHN P. MERRILL, M.D., F.A.C.P.Coccidioidomycosis and Amphotericin BThe Renal Lesion Related to Amphotericin B Treatment for CoccidioidomycosisInfectious Diseases: Annual Review of Significant Publications 1 April 1962Volume 56, Issue 4Page: 553-563KeywordsAmphotericinAnemiaAntifungalsCoccidioidomycosisGratitudePrevention, policy, and public health Issue Published: 1 April 1962 PDF DownloadLoading ..." @default.
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