Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007061536> ?p ?o ?g. }
- W2007061536 endingPage "e1005075" @default.
- W2007061536 startingPage "e1005075" @default.
- W2007061536 abstract "To infer the subclonality of rhabdomyosarcoma (RMS) and predict the temporal order of genetic events for the tumorigenic process, and to identify novel drivers, we applied a systematic method that takes into account germline and somatic alterations in 44 tumor-normal RMS pairs using deep whole-genome sequencing. Intriguingly, we find that loss of heterozygosity of 11p15.5 and mutations in RAS pathway genes occur early in the evolutionary history of the PAX-fusion-negative-RMS (PFN-RMS) subtype. We discover several early mutations in non-RAS mutated samples and predict them to be drivers in PFN-RMS including recurrent mutation of PKN1. In contrast, we find that PAX-fusion-positive (PFP) subtype tumors have undergone whole-genome duplication in the late stage of cancer evolutionary history and have acquired fewer mutations and subclones than PFN-RMS. Moreover we predict that the PAX3-FOXO1 fusion event occurs earlier than the whole genome duplication. Our findings provide information critical to the understanding of tumorigenesis of RMS." @default.
- W2007061536 created "2016-06-24" @default.
- W2007061536 creator A5005290498 @default.
- W2007061536 creator A5009811689 @default.
- W2007061536 creator A5017638182 @default.
- W2007061536 creator A5023076810 @default.
- W2007061536 creator A5023309436 @default.
- W2007061536 creator A5025441472 @default.
- W2007061536 creator A5030202759 @default.
- W2007061536 creator A5037989560 @default.
- W2007061536 creator A5044095151 @default.
- W2007061536 creator A5045973874 @default.
- W2007061536 creator A5081312498 @default.
- W2007061536 creator A5083808934 @default.
- W2007061536 date "2015-03-13" @default.
- W2007061536 modified "2023-10-16" @default.
- W2007061536 title "Clonality and Evolutionary History of Rhabdomyosarcoma" @default.
- W2007061536 cites W1534763236 @default.
- W2007061536 cites W1899944942 @default.
- W2007061536 cites W1905490737 @default.
- W2007061536 cites W1966802202 @default.
- W2007061536 cites W1970442105 @default.
- W2007061536 cites W1971639718 @default.
- W2007061536 cites W1981697868 @default.
- W2007061536 cites W1983725267 @default.
- W2007061536 cites W1986178012 @default.
- W2007061536 cites W1993355130 @default.
- W2007061536 cites W1996181407 @default.
- W2007061536 cites W2015456200 @default.
- W2007061536 cites W2019826954 @default.
- W2007061536 cites W2020804488 @default.
- W2007061536 cites W2023987592 @default.
- W2007061536 cites W2032631136 @default.
- W2007061536 cites W2033666853 @default.
- W2007061536 cites W2034253224 @default.
- W2007061536 cites W2040430549 @default.
- W2007061536 cites W2045802318 @default.
- W2007061536 cites W2048172259 @default.
- W2007061536 cites W2059300459 @default.
- W2007061536 cites W2060310306 @default.
- W2007061536 cites W2060383229 @default.
- W2007061536 cites W2060573548 @default.
- W2007061536 cites W2061393391 @default.
- W2007061536 cites W2062972691 @default.
- W2007061536 cites W2063382533 @default.
- W2007061536 cites W2064644124 @default.
- W2007061536 cites W2084020418 @default.
- W2007061536 cites W2086535578 @default.
- W2007061536 cites W2088118447 @default.
- W2007061536 cites W2088580309 @default.
- W2007061536 cites W2091117089 @default.
- W2007061536 cites W2093144236 @default.
- W2007061536 cites W2093352272 @default.
- W2007061536 cites W2097065948 @default.
- W2007061536 cites W2101035019 @default.
- W2007061536 cites W2103941658 @default.
- W2007061536 cites W2108879393 @default.
- W2007061536 cites W2109991075 @default.
- W2007061536 cites W2114626430 @default.
- W2007061536 cites W2116631863 @default.
- W2007061536 cites W2118071133 @default.
- W2007061536 cites W2119151801 @default.
- W2007061536 cites W2122129817 @default.
- W2007061536 cites W2127736279 @default.
- W2007061536 cites W2128537223 @default.
- W2007061536 cites W2130780169 @default.
- W2007061536 cites W2131072337 @default.
- W2007061536 cites W2135504026 @default.
- W2007061536 cites W2138601221 @default.
- W2007061536 cites W2139383226 @default.
- W2007061536 cites W2141458291 @default.
- W2007061536 cites W2141513637 @default.
- W2007061536 cites W2146949992 @default.
- W2007061536 cites W2147354890 @default.
- W2007061536 cites W2150733855 @default.
- W2007061536 cites W2157912474 @default.
- W2007061536 cites W2160417212 @default.
- W2007061536 cites W2163544895 @default.
- W2007061536 cites W2169895148 @default.
- W2007061536 cites W2560367415 @default.
- W2007061536 doi "https://doi.org/10.1371/journal.pgen.1005075" @default.
- W2007061536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4358975" @default.
- W2007061536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25768946" @default.
- W2007061536 hasPublicationYear "2015" @default.
- W2007061536 type Work @default.
- W2007061536 sameAs 2007061536 @default.
- W2007061536 citedByCount "58" @default.
- W2007061536 countsByYear W20070615362015 @default.
- W2007061536 countsByYear W20070615362016 @default.
- W2007061536 countsByYear W20070615362017 @default.
- W2007061536 countsByYear W20070615362018 @default.
- W2007061536 countsByYear W20070615362019 @default.
- W2007061536 countsByYear W20070615362020 @default.
- W2007061536 countsByYear W20070615362021 @default.
- W2007061536 countsByYear W20070615362022 @default.
- W2007061536 countsByYear W20070615362023 @default.
- W2007061536 crossrefType "journal-article" @default.
- W2007061536 hasAuthorship W2007061536A5005290498 @default.