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- W2007063498 abstract "The TAP1 and LMP2 genes are central for class I MHC function and share a common promoter. Here, we analyze the molecular mechanism of IFNγ up-regulation of TAP1 and LMP2. In vivo footprinting indicates IFNγ up-regulates protein–DNA contacts at an IRF-E that is essential for the up-regulation of TAP1 and LMP2 by IFNγ. Gel shift analysis indicates that this site binds IRF-1. The expression of TAP1 and LMP2 are both greatly reduced in IRF-1-deficient mice. Surface class I MHC as well as CD8+ T cells are reduced in IRF-1−/− mice. The role of IRF-1 in the regulation of TAP1 and LMP2 suggests a mechanism for the antiviral properties of IRF-1 and the unexpected deficiency of CD8+ T cells observed in IRF-1−/− mice." @default.
- W2007063498 created "2016-06-24" @default.
- W2007063498 creator A5010118950 @default.
- W2007063498 creator A5014221796 @default.
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- W2007063498 creator A5085175902 @default.
- W2007063498 creator A5086449836 @default.
- W2007063498 date "1996-10-01" @default.
- W2007063498 modified "2023-10-14" @default.
- W2007063498 title "Regulation of LMP2 and TAP1 Genes by IRF-1 Explains the Paucity of CD8+ T Cells in IRF-1−/− Mice" @default.
- W2007063498 cites W11800597 @default.
- W2007063498 cites W1518511714 @default.
- W2007063498 cites W1537406409 @default.
- W2007063498 cites W164678075 @default.
- W2007063498 cites W1669573844 @default.
- W2007063498 cites W1671456021 @default.
- W2007063498 cites W172605609 @default.
- W2007063498 cites W1758311809 @default.
- W2007063498 cites W1794193241 @default.
- W2007063498 cites W1857506864 @default.
- W2007063498 cites W1954929088 @default.
- W2007063498 cites W1969289904 @default.
- W2007063498 cites W1970030822 @default.
- W2007063498 cites W1974684256 @default.
- W2007063498 cites W1978624555 @default.
- W2007063498 cites W1978757588 @default.
- W2007063498 cites W1980443572 @default.
- W2007063498 cites W1981582155 @default.
- W2007063498 cites W1982273478 @default.
- W2007063498 cites W1985774274 @default.
- W2007063498 cites W1985929162 @default.
- W2007063498 cites W1988345010 @default.
- W2007063498 cites W1993177629 @default.
- W2007063498 cites W1993243592 @default.
- W2007063498 cites W1993292631 @default.
- W2007063498 cites W1994435196 @default.
- W2007063498 cites W1996567630 @default.
- W2007063498 cites W1997215036 @default.
- W2007063498 cites W2004829503 @default.
- W2007063498 cites W2006080840 @default.
- W2007063498 cites W2006629564 @default.
- W2007063498 cites W2018106813 @default.
- W2007063498 cites W2018898580 @default.
- W2007063498 cites W2021951044 @default.
- W2007063498 cites W2027225184 @default.
- W2007063498 cites W2029060163 @default.
- W2007063498 cites W2033531531 @default.
- W2007063498 cites W2035167769 @default.
- W2007063498 cites W2037772620 @default.
- W2007063498 cites W2039672885 @default.
- W2007063498 cites W2046105249 @default.
- W2007063498 cites W2047089647 @default.
- W2007063498 cites W2051751863 @default.
- W2007063498 cites W2051953984 @default.
- W2007063498 cites W2052025279 @default.
- W2007063498 cites W2053597753 @default.
- W2007063498 cites W2054132042 @default.
- W2007063498 cites W2055034075 @default.
- W2007063498 cites W2060736209 @default.
- W2007063498 cites W2062049067 @default.
- W2007063498 cites W2062433816 @default.
- W2007063498 cites W2064675349 @default.
- W2007063498 cites W2067267037 @default.
- W2007063498 cites W2068871282 @default.
- W2007063498 cites W2071692669 @default.
- W2007063498 cites W2077147012 @default.
- W2007063498 cites W2078593364 @default.
- W2007063498 cites W2081499148 @default.
- W2007063498 cites W2082173837 @default.
- W2007063498 cites W2083104350 @default.
- W2007063498 cites W2083988731 @default.
- W2007063498 cites W2085275703 @default.
- W2007063498 cites W2085450869 @default.
- W2007063498 cites W2088635433 @default.
- W2007063498 cites W2089262366 @default.
- W2007063498 cites W2092725115 @default.
- W2007063498 cites W2093874299 @default.
- W2007063498 cites W2099340972 @default.
- W2007063498 cites W2101271083 @default.
- W2007063498 cites W2102683915 @default.
- W2007063498 cites W2102776981 @default.
- W2007063498 cites W2104710873 @default.
- W2007063498 cites W2105360761 @default.
- W2007063498 cites W2105370088 @default.
- W2007063498 cites W2106315019 @default.
- W2007063498 cites W2109478329 @default.
- W2007063498 cites W2109484445 @default.
- W2007063498 cites W2119092109 @default.
- W2007063498 cites W2122515314 @default.
- W2007063498 cites W2141216457 @default.
- W2007063498 cites W2143257167 @default.
- W2007063498 cites W2143359784 @default.
- W2007063498 cites W2146736041 @default.
- W2007063498 cites W2153987432 @default.
- W2007063498 cites W2163853656 @default.
- W2007063498 cites W2167102170 @default.