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- W2007065404 abstract "Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification." @default.
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- W2007065404 date "2010-09-01" @default.
- W2007065404 modified "2023-09-29" @default.
- W2007065404 title "Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?" @default.
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- W2007065404 doi "https://doi.org/10.1016/j.leukres.2010.03.022" @default.
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