FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007067102> ?p ?o ?g. }

• W2007067102 endingPage "358" @default.
• W2007067102 startingPage "350" @default.
• W2007067102 abstract "A series of tetracyclic thienopyrimidines (7–14) was prepared and investigated as inhibitors of acetylcholinesterase from Electrophorus electricus acetylcholinesterase (EeAChE), as well as human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). A new synthetic procedure was employed for the synthesis of the angularly fused heterocycles 7–10. Among them, the presence of a tetrahydropyrido ring with a benzyl rest at the basic nitrogen was required for EeAChE inhibition. A detailed kinetic analysis of the hyperbolic mixed-type inhibition of EeAChE by 9–14 was performed. These heterocyclic compounds inhibited EeAChE with Ki values of less than 3 µM. Most α values were relatively close to 1, indicating a similar affinity of the inhibitor to the free enzyme and the enzyme-substrate complex. Inhibitor 10 displayed a rather uncompetitive pattern of inhibition (α = 0.47) and a relatively high residual activity of a postulated ternary enzyme-substrate-inhibitor complex (β = 0.24)." @default.
• W2007067102 created "2016-06-24" @default.
• W2007067102 creator A5036207297 @default.
• W2007067102 creator A5078362718 @default.
• W2007067102 date "2010-08-31" @default.
• W2007067102 modified "2023-09-27" @default.
• W2007067102 title "Hyperbolic mixed-type inhibition of acetylcholinesterase by tetracyclic thienopyrimidines" @default.
• W2007067102 cites W1432624184 @default.
• W2007067102 cites W1561647671 @default.
• W2007067102 cites W1562398969 @default.
• W2007067102 cites W1969451266 @default.
• W2007067102 cites W1971048984 @default.
• W2007067102 cites W1979552709 @default.
• W2007067102 cites W1979683764 @default.
• W2007067102 cites W1993672505 @default.
• W2007067102 cites W1994693522 @default.
• W2007067102 cites W2001226246 @default.
• W2007067102 cites W2003633347 @default.
• W2007067102 cites W2025644108 @default.
• W2007067102 cites W2027955282 @default.
• W2007067102 cites W2028746540 @default.
• W2007067102 cites W2063268875 @default.
• W2007067102 cites W2071254799 @default.
• W2007067102 cites W2078491743 @default.
• W2007067102 cites W2085958374 @default.
• W2007067102 cites W2087538505 @default.
• W2007067102 cites W2088387056 @default.
• W2007067102 cites W2088947290 @default.
• W2007067102 cites W2089112315 @default.
• W2007067102 cites W2101472522 @default.
• W2007067102 cites W2121322934 @default.
• W2007067102 cites W2137809729 @default.
• W2007067102 cites W2144135498 @default.
• W2007067102 cites W2149728196 @default.
• W2007067102 cites W2327708626 @default.
• W2007067102 doi "https://doi.org/10.3109/14756366.2010.504674" @default.
• W2007067102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20807084" @default.
• W2007067102 hasPublicationYear "2010" @default.
• W2007067102 type Work @default.
• W2007067102 sameAs 2007067102 @default.
• W2007067102 citedByCount "14" @default.
• W2007067102 countsByYear W20070671022013 @default.
• W2007067102 countsByYear W20070671022015 @default.
• W2007067102 countsByYear W20070671022017 @default.
• W2007067102 countsByYear W20070671022020 @default.
• W2007067102 countsByYear W20070671022021 @default.
• W2007067102 countsByYear W20070671022022 @default.
• W2007067102 countsByYear W20070671022023 @default.
• W2007067102 crossrefType "journal-article" @default.
• W2007067102 hasAuthorship W2007067102A5036207297 @default.
• W2007067102 hasAuthorship W2007067102A5078362718 @default.
• W2007067102 hasBestOaLocation W20070671021 @default.
• W2007067102 hasConcept C123419017 @default.
• W2007067102 hasConcept C14728290 @default.
• W2007067102 hasConcept C150757390 @default.
• W2007067102 hasConcept C158685282 @default.
• W2007067102 hasConcept C170493617 @default.
• W2007067102 hasConcept C178790620 @default.
• W2007067102 hasConcept C181199279 @default.
• W2007067102 hasConcept C185592680 @default.
• W2007067102 hasConcept C18903297 @default.
• W2007067102 hasConcept C2776980637 @default.
• W2007067102 hasConcept C2777289219 @default.
• W2007067102 hasConcept C2777544248 @default.
• W2007067102 hasConcept C2778816929 @default.
• W2007067102 hasConcept C2779059548 @default.
• W2007067102 hasConcept C2779101902 @default.
• W2007067102 hasConcept C2779715943 @default.
• W2007067102 hasConcept C2780378348 @default.
• W2007067102 hasConcept C55493867 @default.
• W2007067102 hasConcept C71240020 @default.
• W2007067102 hasConcept C80161118 @default.
• W2007067102 hasConcept C86803240 @default.
• W2007067102 hasConceptScore W2007067102C123419017 @default.
• W2007067102 hasConceptScore W2007067102C14728290 @default.
• W2007067102 hasConceptScore W2007067102C150757390 @default.
• W2007067102 hasConceptScore W2007067102C158685282 @default.
• W2007067102 hasConceptScore W2007067102C170493617 @default.
• W2007067102 hasConceptScore W2007067102C178790620 @default.
• W2007067102 hasConceptScore W2007067102C181199279 @default.
• W2007067102 hasConceptScore W2007067102C185592680 @default.
• W2007067102 hasConceptScore W2007067102C18903297 @default.
• W2007067102 hasConceptScore W2007067102C2776980637 @default.
• W2007067102 hasConceptScore W2007067102C2777289219 @default.
• W2007067102 hasConceptScore W2007067102C2777544248 @default.
• W2007067102 hasConceptScore W2007067102C2778816929 @default.
• W2007067102 hasConceptScore W2007067102C2779059548 @default.
• W2007067102 hasConceptScore W2007067102C2779101902 @default.
• W2007067102 hasConceptScore W2007067102C2779715943 @default.
• W2007067102 hasConceptScore W2007067102C2780378348 @default.
• W2007067102 hasConceptScore W2007067102C55493867 @default.
• W2007067102 hasConceptScore W2007067102C71240020 @default.
• W2007067102 hasConceptScore W2007067102C80161118 @default.
• W2007067102 hasConceptScore W2007067102C86803240 @default.
• W2007067102 hasIssue "3" @default.
• W2007067102 hasLocation W20070671021 @default.
• W2007067102 hasLocation W20070671022 @default.
• W2007067102 hasOpenAccess W2007067102 @default.

• next