Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007067975> ?p ?o ?g. }
- W2007067975 endingPage "58" @default.
- W2007067975 startingPage "33" @default.
- W2007067975 abstract "Eye-drops are the conventional dosage forms that account for 90% of currently accessible ophthalmic formulations. Despite the excellent acceptance by patients, one of the major problems encountered is rapid precorneal drug loss. To improve ocular drug bioavailability, there is a significant effort directed towards new drug delivery systems for ophthalmic administration. This chapter will focus on three representative areas of ophthalmic drug delivery systems: polymeric gels, colloidal systems, cyclodextrins and collagen shields. Hydrogels generally offer a moderate improvement of ocular drug bioavailability with the disadvantage of blurring of vision. In situ activated gel-forming systems are preferred as they can be delivered in drop form with sustained release properties. Colloidal systems including liposomes and nanoparticles have the convenience of a drop, which is able to maintain drug activity at its site of action and is suitable for poorly water-soluble drugs. Among the new therapeutic approaches in ophthalmology, cyclodextrins represent an alternative approach to increase the solubility of the drug in solution and to increase corneal permeability. Finally, collagen shields have been developed as a new continuous-delivery system for drugs that provide high and sustained levels of drugs to the cornea, despite a problem of tolerance. It seems that new tendency of research in ophthalmic drug delivery systems is directed towards a combination of several drug delivery technologies. There is a tendency to develop systems which not only prolong the contact time of the vehicle at the ocular surface, but which at the same time slow down the elimination of the drug. Combination of drug delivery systems could open a new directive for improving results and the therapeutic response of non-efficacious systems." @default.
- W2007067975 created "2016-06-24" @default.
- W2007067975 creator A5011577017 @default.
- W2007067975 creator A5021027378 @default.
- W2007067975 creator A5021697584 @default.
- W2007067975 creator A5028574629 @default.
- W2007067975 creator A5042170265 @default.
- W2007067975 creator A5060490541 @default.
- W2007067975 date "1998-01-01" @default.
- W2007067975 modified "2023-10-18" @default.
- W2007067975 title "Ophthalmic drug delivery systems—Recent advances" @default.
- W2007067975 cites W10043197 @default.
- W2007067975 cites W138624324 @default.
- W2007067975 cites W1591566813 @default.
- W2007067975 cites W1592964052 @default.
- W2007067975 cites W1595265868 @default.
- W2007067975 cites W171574099 @default.
- W2007067975 cites W195278903 @default.
- W2007067975 cites W1963800128 @default.
- W2007067975 cites W1963934856 @default.
- W2007067975 cites W1964220679 @default.
- W2007067975 cites W1964774181 @default.
- W2007067975 cites W1967892728 @default.
- W2007067975 cites W1972218244 @default.
- W2007067975 cites W1972583535 @default.
- W2007067975 cites W1973901893 @default.
- W2007067975 cites W1975364272 @default.
- W2007067975 cites W1976901778 @default.
- W2007067975 cites W1977681006 @default.
- W2007067975 cites W1982809657 @default.
- W2007067975 cites W1984196075 @default.
- W2007067975 cites W1985241673 @default.
- W2007067975 cites W1986180285 @default.
- W2007067975 cites W1986318566 @default.
- W2007067975 cites W1987324444 @default.
- W2007067975 cites W1988403567 @default.
- W2007067975 cites W1990016995 @default.
- W2007067975 cites W1991088254 @default.
- W2007067975 cites W1992812840 @default.
- W2007067975 cites W1993886004 @default.
- W2007067975 cites W1995207112 @default.
- W2007067975 cites W1996375215 @default.
- W2007067975 cites W1997566617 @default.
- W2007067975 cites W1998461443 @default.
- W2007067975 cites W1998975741 @default.
- W2007067975 cites W2001093916 @default.
- W2007067975 cites W2001689210 @default.
- W2007067975 cites W2003936338 @default.
- W2007067975 cites W2005907688 @default.
- W2007067975 cites W2005931732 @default.
- W2007067975 cites W2009719560 @default.
- W2007067975 cites W2011078004 @default.
- W2007067975 cites W2016703296 @default.
- W2007067975 cites W2021627022 @default.
- W2007067975 cites W2023455569 @default.
- W2007067975 cites W2023668340 @default.
- W2007067975 cites W2023687292 @default.
- W2007067975 cites W2024971454 @default.
- W2007067975 cites W2026086228 @default.
- W2007067975 cites W2026156584 @default.
- W2007067975 cites W2026788844 @default.
- W2007067975 cites W2027938329 @default.
- W2007067975 cites W2028740273 @default.
- W2007067975 cites W2029446966 @default.
- W2007067975 cites W2030213850 @default.
- W2007067975 cites W2030817962 @default.
- W2007067975 cites W2032139653 @default.
- W2007067975 cites W2035305167 @default.
- W2007067975 cites W2035483433 @default.
- W2007067975 cites W2036318521 @default.
- W2007067975 cites W2038289365 @default.
- W2007067975 cites W2038384642 @default.
- W2007067975 cites W2040318232 @default.
- W2007067975 cites W2042274420 @default.
- W2007067975 cites W2043507378 @default.
- W2007067975 cites W2044080091 @default.
- W2007067975 cites W2046118526 @default.
- W2007067975 cites W2046264407 @default.
- W2007067975 cites W2046450137 @default.
- W2007067975 cites W2048115865 @default.
- W2007067975 cites W2049324992 @default.
- W2007067975 cites W2051075258 @default.
- W2007067975 cites W2051127111 @default.
- W2007067975 cites W2051811246 @default.
- W2007067975 cites W2051842899 @default.
- W2007067975 cites W2052093626 @default.
- W2007067975 cites W2052118906 @default.
- W2007067975 cites W2052235472 @default.
- W2007067975 cites W2055273656 @default.
- W2007067975 cites W2055322418 @default.
- W2007067975 cites W2056529989 @default.
- W2007067975 cites W2057843842 @default.
- W2007067975 cites W2059791311 @default.
- W2007067975 cites W2060397516 @default.
- W2007067975 cites W2064453451 @default.
- W2007067975 cites W2064972870 @default.
- W2007067975 cites W2067158167 @default.
- W2007067975 cites W2068917523 @default.