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- W2007068109 abstract "Trichlorobiphenyl induced only CYP1A2 mRNA, while pentachlorobiphenyl induced both CYP1A2 and CYP2B1 mRNAs in rat liver. The mRNA levels for these P450s were elevated when ascorbic acid-deficient ODS rats (mutant rats with a hereditary osteogenic disorder) were fed a diet supplemented with ascorbic acid. The amount of CYP2B1 mRNA increased rapidly and reached a maximum level of approximately double within 24 hr of injection of pentachlorobiphenyl. Thereafter, the amount of its mRNA decreased to a steady level. This pattern was roughly paralleled by changes in the amount of CYP1A2 mRNA." @default.
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- W2007068109 date "1993-07-01" @default.
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- W2007068109 title "Ascorbate-dependent elevation of mRNA levels for cytochrome P450s induced by polychlorinated biphenyls" @default.
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- W2007068109 doi "https://doi.org/10.1016/0006-2952(93)90365-4" @default.
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