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• W2007070180 abstract "Mutations of the p53 tumor suppressor gene are frequent in lung cancers. It is suggested that p53 mutations are associated with smoking-induced lung carcinogenesis. We examined p53 mutations in 53 lung cancers by analyzing reverse transcription-polymerase chain reaction-single strand conformation polymorphism (RT-PCR-SSCP) to ascertain the association between p53 mutations and smoking. Twenty-five (47%) of 53 lung cancers carried p53 mutations. A discriminant analysis showed that the Brinkman index (0.156) and gender (0.140) significantly influenced p53 mutations. Furthermore, there was a dose-response relationship between the quantity of cigarettes consumed and the frequency of p53 mutations in lung cancer patients (P < 0.001). In patients with adenocarcinoma, the frequency of p53 mutations correlated with the amount of the tobacco smoked (P < 0.05). We suggest that the p53 gene is a target of particular carcinogen in tobacco smoke. © 1996 Wiley-Liss, Inc." @default.
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• W2007070180 date "1996-01-01" @default.
• W2007070180 modified "2023-09-27" @default.
• W2007070180 title "A dose-response relationship between the frequency of p53 mutations and tobacco consumption in lung cancer patients" @default.
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• W2007070180 doi "https://doi.org/10.1002/(sici)1096-9098(199601)61:1<20::aid-jso6>3.0.co;2-u" @default.
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