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- W2007079111 abstract "DNA polymerase β levels were measured in 4 cell lines of normal human skin fibroblasts and in 5 cell lines of skin fibroblasts from patients with ataxia telangiectasia, an autosomal recessive disease exhibiting marked X-ray sensitivity. The enzyme specific activities for the normal lines were similar and the mean value was 2-fold lower than the mean value for the ataxia lines. With both kinds of cells, the enzyme level did not change as the cultures progressed from logarithmic to stationary phase of growth. Thus, this putative DNA repair enzyme appears to be ‘constitutive’ in human skin fibroblasts lines, and a modest elevation of β-polymerase activity is associated with ataxia telangiectasia. These results are discussed in the context to current views about DNA-repair enzymes in X-ray-sensitive cultured mammalian cells." @default.
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- W2007079111 date "1985-11-01" @default.
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- W2007079111 title "Measurement of DNA polymerase β in skin fibroblast cell lines from patients with ataxia telangiectasia" @default.
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- W2007079111 doi "https://doi.org/10.1016/0167-8817(85)90071-9" @default.
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