Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007079553> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2007079553 endingPage "1107" @default.
- W2007079553 startingPage "1103" @default.
- W2007079553 abstract "In Brief Local anesthetics suppress proliferation in several cancer cells. The mechanism of the suppression, however, is unknown. Our previous study shows that lidocaine, at the level of tissue concentration under topical or local administration, has a direct inhibitory effect on the activity of epidermal growth factor receptor (EGFR), which is a potential target for antiproliferation in cancer cells. Therefore, we hypothesized that lidocaine would suppress the proliferation of cancer cells through the inhibition of EGFR activity. We investigated the effects of lidocaine (40–4000 μM) on proliferation of a human tongue cancer cell line, CAL27, which has a high level of EGFR expression, and also examined the effect of lidocaine on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR in CAL27 cells. A clinical concentration of lidocaine (400 μM) suppressed both serum-induced and EGF-induced proliferation of CAL27 cells and inhibited EGF-stimulated tyrosine kinase activity of EGFR without cytotoxicity. A larger concentration of lidocaine (4000 μM) showed cytotoxicity with an antiproliferative effect. We suggest that the inhibition of EGF-stimulated EGFR activity is one of the mechanisms of the antiproliferative effect of lidocaine on CAL27 cells. Lidocaine administered topically within the oral cavity for cancer pain relief may suppress the proliferation of human tongue cancer cells. IMPLICATIONS: Topical local anesthetics are used for cancer pain relief and may suppress the proliferation of cancer cells. We investigated the effects of lidocaine on proliferation of the human tongue cancer cell line CAL27. A clinical concentration of lidocaine suppressed the proliferation of CAL27 with inhibition of the activity of the epidermal growth factor receptor." @default.
- W2007079553 created "2016-06-24" @default.
- W2007079553 creator A5025834544 @default.
- W2007079553 creator A5031435054 @default.
- W2007079553 creator A5034635351 @default.
- W2007079553 date "2006-04-01" @default.
- W2007079553 modified "2023-10-14" @default.
- W2007079553 title "The Antiproliferative Effect of Lidocaine on Human Tongue Cancer Cells with Inhibition of the Activity of Epidermal Growth Factor Receptor" @default.
- W2007079553 cites W1580361048 @default.
- W2007079553 cites W1969530011 @default.
- W2007079553 cites W1990396528 @default.
- W2007079553 cites W1999962206 @default.
- W2007079553 cites W2000353746 @default.
- W2007079553 cites W2005346853 @default.
- W2007079553 cites W2022638801 @default.
- W2007079553 cites W2029580509 @default.
- W2007079553 cites W2077163008 @default.
- W2007079553 cites W2093001812 @default.
- W2007079553 cites W2106677327 @default.
- W2007079553 cites W2110729667 @default.
- W2007079553 cites W2138145147 @default.
- W2007079553 doi "https://doi.org/10.1213/01.ane.0000198330.84341.35" @default.
- W2007079553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16551906" @default.
- W2007079553 hasPublicationYear "2006" @default.
- W2007079553 type Work @default.
- W2007079553 sameAs 2007079553 @default.
- W2007079553 citedByCount "118" @default.
- W2007079553 countsByYear W20070795532012 @default.
- W2007079553 countsByYear W20070795532013 @default.
- W2007079553 countsByYear W20070795532014 @default.
- W2007079553 countsByYear W20070795532015 @default.
- W2007079553 countsByYear W20070795532016 @default.
- W2007079553 countsByYear W20070795532017 @default.
- W2007079553 countsByYear W20070795532018 @default.
- W2007079553 countsByYear W20070795532019 @default.
- W2007079553 countsByYear W20070795532020 @default.
- W2007079553 countsByYear W20070795532021 @default.
- W2007079553 countsByYear W20070795532022 @default.
- W2007079553 countsByYear W20070795532023 @default.
- W2007079553 crossrefType "journal-article" @default.
- W2007079553 hasAuthorship W2007079553A5025834544 @default.
- W2007079553 hasAuthorship W2007079553A5031435054 @default.
- W2007079553 hasAuthorship W2007079553A5034635351 @default.
- W2007079553 hasBestOaLocation W20070795531 @default.
- W2007079553 hasConcept C121608353 @default.
- W2007079553 hasConcept C126322002 @default.
- W2007079553 hasConcept C170493617 @default.
- W2007079553 hasConcept C2776362946 @default.
- W2007079553 hasConcept C2779438470 @default.
- W2007079553 hasConcept C2780149897 @default.
- W2007079553 hasConcept C42219234 @default.
- W2007079553 hasConcept C502942594 @default.
- W2007079553 hasConcept C54355233 @default.
- W2007079553 hasConcept C55493867 @default.
- W2007079553 hasConcept C62112901 @default.
- W2007079553 hasConcept C71924100 @default.
- W2007079553 hasConcept C81885089 @default.
- W2007079553 hasConcept C86803240 @default.
- W2007079553 hasConcept C96232424 @default.
- W2007079553 hasConcept C98274493 @default.
- W2007079553 hasConceptScore W2007079553C121608353 @default.
- W2007079553 hasConceptScore W2007079553C126322002 @default.
- W2007079553 hasConceptScore W2007079553C170493617 @default.
- W2007079553 hasConceptScore W2007079553C2776362946 @default.
- W2007079553 hasConceptScore W2007079553C2779438470 @default.
- W2007079553 hasConceptScore W2007079553C2780149897 @default.
- W2007079553 hasConceptScore W2007079553C42219234 @default.
- W2007079553 hasConceptScore W2007079553C502942594 @default.
- W2007079553 hasConceptScore W2007079553C54355233 @default.
- W2007079553 hasConceptScore W2007079553C55493867 @default.
- W2007079553 hasConceptScore W2007079553C62112901 @default.
- W2007079553 hasConceptScore W2007079553C71924100 @default.
- W2007079553 hasConceptScore W2007079553C81885089 @default.
- W2007079553 hasConceptScore W2007079553C86803240 @default.
- W2007079553 hasConceptScore W2007079553C96232424 @default.
- W2007079553 hasConceptScore W2007079553C98274493 @default.
- W2007079553 hasIssue "4" @default.
- W2007079553 hasLocation W20070795531 @default.
- W2007079553 hasLocation W20070795532 @default.
- W2007079553 hasLocation W20070795533 @default.
- W2007079553 hasOpenAccess W2007079553 @default.
- W2007079553 hasPrimaryLocation W20070795531 @default.
- W2007079553 hasRelatedWork W1649909918 @default.
- W2007079553 hasRelatedWork W2024108044 @default.
- W2007079553 hasRelatedWork W2035715047 @default.
- W2007079553 hasRelatedWork W2166292885 @default.
- W2007079553 hasRelatedWork W2378785636 @default.
- W2007079553 hasRelatedWork W2395493263 @default.
- W2007079553 hasRelatedWork W2433612656 @default.
- W2007079553 hasRelatedWork W2796029931 @default.
- W2007079553 hasRelatedWork W2940449836 @default.
- W2007079553 hasRelatedWork W4304116770 @default.
- W2007079553 hasVolume "102" @default.
- W2007079553 isParatext "false" @default.
- W2007079553 isRetracted "false" @default.
- W2007079553 magId "2007079553" @default.
- W2007079553 workType "article" @default.