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• W2007082752 abstract "The purpose of this study was to elucidate the central processing of painful mechanical stimulation to muscle and bone by measuring blood oxygen level-dependent signal changes using functional magnetic resonance imaging (fMRI). Twelve healthy volunteers were enrolled. Mechanical pressure on muscle and bone were applied at the right lower leg by an algometer. Intensities were adjusted to cause weak and strong pain sensation at either target site in preliminary testing. Brain activation in response to mechanical nociceptive stimulation targeting muscle and bone were measured by fMRI and analyzed. Painful mechanical stimulation targeting muscle and bone activated the common areas including bilateral insula, anterior cingulate cortex, posterior cingulate cortex, secondary somatosensory cortex (S2), inferior parietal lobe, and basal ganglia. The contralateral S2 was more activated by strong stimulation than by weak stimulation. Some areas in the basal ganglia (bilateral putamen and caudate nucleus) were more activated by muscle stimulation than by bone stimulation. The putamen and caudate nucleus may have a more significant role in brain processing of muscle pain compared with bone pain." @default.
• W2007082752 created "2016-06-24" @default.
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• W2007082752 date "2011-06-02" @default.
• W2007082752 modified "2023-10-14" @default.
• W2007082752 title "Human brain activity associated with painful mechanical stimulation to muscle and bone" @default.
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• W2007082752 doi "https://doi.org/10.1007/s00540-011-1173-9" @default.
• W2007082752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3152719" @default.
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