FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007086659> ?p ?o ?g. }

• W2007086659 endingPage "214" @default.
• W2007086659 startingPage "205" @default.
• W2007086659 abstract "The aim of this study was to compare, in a randomized multicenter trial, paclitaxel-eluting stents (CoStar, Conor Medsystems, Menlo Park, California) versus pimecrolimus-eluting stents (Corio, Conor Medsystems) versus stents with dual elution of both drugs (SymBio, Conor Medsystems) in native coronary arteries.The CoStar cobalt-chromium reservoir-based stent platform, eluting paclitaxel in a controlled way via a bioresorbable polymer, reduces restenosis versus its respective bare-metal stent. The reservoir system allows the use of other drugs targeted to different mechanisms involved in the process of vascular restenosis and simultaneous loading of multiple, synergistic drugs.Patients with single de novo lesions were asymmetrically randomized to 1 of the 3 types of stent (1:2:2). Six-month coronary angiography was planned in all. The primary analysis was a noninferiority test for the primary end point of 6-month angiographic in-stent late lumen loss of Corio versus CoStar and SymBio versus CoStar. Secondary end points included binary angiographic restenosis and major adverse clinical events (cardiac death, myocardial infarction, target vessel revascularization).The trial was prematurely suspended after 246 patients were enrolled (planned enrollment: 375 patients): 49 patients received CoStar, 97 received SymBio, and 100 received Corio. In-stent late loss was significantly reduced with CoStar versus either SymBio or Corio (0.58 +/- 0.58 mm vs. 0.96 +/- 0.73 mm and 0.58 +/- 0.58 mm vs. 1.40 +/- 0.67 mm, p < 0.001 for both comparisons). Binary in-stent restenosis rates were, 7.1%, 20%, and 40.9%, respectively (p < 0.001 for both comparisons); 6-month major adverse cardiac event rates were, 2.0%, 14.4%, and 39.0%, respectively (p < 0.001 for both comparisons).Stents eluting pimecrolimus or the dual combination of pimecrolimus and paclitaxel failed to show angiographic noninferiority when compared with paclitaxel-eluting stents. (A Randomized, Multi-Center Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent Systems; NCT00322569)." @default.
• W2007086659 created "2016-06-24" @default.
• W2007086659 creator A5004558402 @default.
• W2007086659 creator A5005824029 @default.
• W2007086659 creator A5006222269 @default.
• W2007086659 creator A5007202415 @default.
• W2007086659 creator A5009224311 @default.
• W2007086659 creator A5039632207 @default.
• W2007086659 creator A5042455711 @default.
• W2007086659 creator A5044661544 @default.
• W2007086659 creator A5046208454 @default.
• W2007086659 creator A5054187249 @default.
• W2007086659 creator A5079278619 @default.
• W2007086659 creator A5080326925 @default.
• W2007086659 date "2009-03-01" @default.
• W2007086659 modified "2023-10-02" @default.
• W2007086659 title "The GENESIS (Randomized, Multicenter Study of the Pimecrolimus-Eluting and Pimecrolimus/Paclitaxel-Eluting Coronary Stent System in Patients with De Novo Lesions of the Native Coronary Arteries) Trial" @default.
• W2007086659 cites W1546516142 @default.
• W2007086659 cites W1975509390 @default.
• W2007086659 cites W1983888865 @default.
• W2007086659 cites W1994541424 @default.
• W2007086659 cites W1997929214 @default.
• W2007086659 cites W200828703 @default.
• W2007086659 cites W2026168678 @default.
• W2007086659 cites W2029775229 @default.
• W2007086659 cites W2036155733 @default.
• W2007086659 cites W2051284169 @default.
• W2007086659 cites W2082446202 @default.
• W2007086659 cites W2083525577 @default.
• W2007086659 cites W2087150869 @default.
• W2007086659 cites W2130250466 @default.
• W2007086659 cites W2143175539 @default.
• W2007086659 cites W2150755435 @default.
• W2007086659 cites W2169000150 @default.
• W2007086659 cites W26259090 @default.
• W2007086659 cites W30025017 @default.
• W2007086659 doi "https://doi.org/10.1016/j.jcin.2008.12.011" @default.
• W2007086659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19463427" @default.
• W2007086659 hasPublicationYear "2009" @default.
• W2007086659 type Work @default.
• W2007086659 sameAs 2007086659 @default.
• W2007086659 citedByCount "32" @default.
• W2007086659 countsByYear W20070866592012 @default.
• W2007086659 countsByYear W20070866592013 @default.
• W2007086659 countsByYear W20070866592014 @default.
• W2007086659 countsByYear W20070866592015 @default.
• W2007086659 countsByYear W20070866592016 @default.
• W2007086659 countsByYear W20070866592017 @default.
• W2007086659 countsByYear W20070866592019 @default.
• W2007086659 crossrefType "journal-article" @default.
• W2007086659 hasAuthorship W2007086659A5004558402 @default.
• W2007086659 hasAuthorship W2007086659A5005824029 @default.
• W2007086659 hasAuthorship W2007086659A5006222269 @default.
• W2007086659 hasAuthorship W2007086659A5007202415 @default.
• W2007086659 hasAuthorship W2007086659A5009224311 @default.
• W2007086659 hasAuthorship W2007086659A5039632207 @default.
• W2007086659 hasAuthorship W2007086659A5042455711 @default.
• W2007086659 hasAuthorship W2007086659A5044661544 @default.
• W2007086659 hasAuthorship W2007086659A5046208454 @default.
• W2007086659 hasAuthorship W2007086659A5054187249 @default.
• W2007086659 hasAuthorship W2007086659A5079278619 @default.
• W2007086659 hasAuthorship W2007086659A5080326925 @default.
• W2007086659 hasBestOaLocation W20070866591 @default.
• W2007086659 hasConcept C126322002 @default.
• W2007086659 hasConcept C141071460 @default.
• W2007086659 hasConcept C164705383 @default.
• W2007086659 hasConcept C168563851 @default.
• W2007086659 hasConcept C203092338 @default.
• W2007086659 hasConcept C2776694085 @default.
• W2007086659 hasConcept C2776820930 @default.
• W2007086659 hasConcept C2777292972 @default.
• W2007086659 hasConcept C2777546689 @default.
• W2007086659 hasConcept C2778283817 @default.
• W2007086659 hasConcept C2778583881 @default.
• W2007086659 hasConcept C2778742706 @default.
• W2007086659 hasConcept C2779983491 @default.
• W2007086659 hasConcept C500558357 @default.
• W2007086659 hasConcept C71924100 @default.
• W2007086659 hasConceptScore W2007086659C126322002 @default.
• W2007086659 hasConceptScore W2007086659C141071460 @default.
• W2007086659 hasConceptScore W2007086659C164705383 @default.
• W2007086659 hasConceptScore W2007086659C168563851 @default.
• W2007086659 hasConceptScore W2007086659C203092338 @default.
• W2007086659 hasConceptScore W2007086659C2776694085 @default.
• W2007086659 hasConceptScore W2007086659C2776820930 @default.
• W2007086659 hasConceptScore W2007086659C2777292972 @default.
• W2007086659 hasConceptScore W2007086659C2777546689 @default.
• W2007086659 hasConceptScore W2007086659C2778283817 @default.
• W2007086659 hasConceptScore W2007086659C2778583881 @default.
• W2007086659 hasConceptScore W2007086659C2778742706 @default.
• W2007086659 hasConceptScore W2007086659C2779983491 @default.
• W2007086659 hasConceptScore W2007086659C500558357 @default.
• W2007086659 hasConceptScore W2007086659C71924100 @default.
• W2007086659 hasIssue "3" @default.
• W2007086659 hasLocation W20070866591 @default.
• W2007086659 hasLocation W20070866592 @default.
• W2007086659 hasOpenAccess W2007086659 @default.
• W2007086659 hasPrimaryLocation W20070866591 @default.

• next