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- W2007086780 abstract "The recent determination of the complete genome sequence of Corynebacterium diphtheriae, the aetiological agent of diphtheria, has allowed a detailed comparison of its physiology with that of its closest sequenced pathogenic relative Mycobacterium tuberculosis. Of major importance to the pathogenicity and resilience of the latter is its particularly complex cell envelope. The corynebacteria share many of the features of this extraordinary structure although to a lesser level of complexity. The cell envelope of M. tuberculosis has provided the molecular targets for several of the major anti-tubercular drugs. Given a backdrop of emerging multi-drug resistant strains of the organism (MDR-TB) and its continuing global threat to human health, the search for novel anti-tubercular agents is of paramount importance. The unique structure of this cell wall and the importance of its integrity to the viability of the organism suggest that the search for novel drug targets within the array of enzymes responsible for its construction may prove fruitful. Although the application of modern bioinformatics techniques to the ‘mining’ of the M. tuberculosis genome has already increased our knowledge of the biosynthesis and assembly of the mycobacterial cell wall, several issues remain uncertain. Further analysis by comparison with its relatives may bring clarity and aid the early identification of novel cellular targets for new anti-tuberculosis drugs. In order to facilitate this aim, this review intends to illustrate the broad similarities and highlight the structural differences between the two bacterial envelopes and discuss the genetics of their biosynthesis." @default.
- W2007086780 created "2016-06-24" @default.
- W2007086780 creator A5016293777 @default.
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- W2007086780 creator A5084268602 @default.
- W2007086780 date "2004-05-01" @default.
- W2007086780 modified "2023-09-28" @default.
- W2007086780 title "Comparative cell wall core biosynthesis in the mycolated pathogens,<i>Mycobacterium tuberculosis</i>and<i>Corynebacterium diphtheriae</i>" @default.
- W2007086780 cites W13600120 @default.
- W2007086780 cites W1484575345 @default.
- W2007086780 cites W1493996922 @default.
- W2007086780 cites W1504706957 @default.
- W2007086780 cites W1507948058 @default.
- W2007086780 cites W1511568218 @default.
- W2007086780 cites W1522208682 @default.
- W2007086780 cites W1538606779 @default.
- W2007086780 cites W1552418306 @default.
- W2007086780 cites W1554875561 @default.
- W2007086780 cites W1590673420 @default.
- W2007086780 cites W1643004344 @default.
- W2007086780 cites W1643997192 @default.
- W2007086780 cites W1756510994 @default.
- W2007086780 cites W1758267623 @default.
- W2007086780 cites W179723514 @default.
- W2007086780 cites W1798947166 @default.
- W2007086780 cites W1826647060 @default.
- W2007086780 cites W1838348255 @default.
- W2007086780 cites W1858344224 @default.
- W2007086780 cites W1870140643 @default.
- W2007086780 cites W1880132961 @default.
- W2007086780 cites W1912527875 @default.
- W2007086780 cites W1966719805 @default.
- W2007086780 cites W1967073350 @default.
- W2007086780 cites W1968104649 @default.
- W2007086780 cites W1968230841 @default.
- W2007086780 cites W1968441416 @default.
- W2007086780 cites W1969144272 @default.
- W2007086780 cites W1970815975 @default.
- W2007086780 cites W1971003485 @default.
- W2007086780 cites W1971087365 @default.
- W2007086780 cites W1972961211 @default.
- W2007086780 cites W1979061379 @default.
- W2007086780 cites W1981675263 @default.
- W2007086780 cites W1982542062 @default.
- W2007086780 cites W1982843047 @default.
- W2007086780 cites W1985649033 @default.
- W2007086780 cites W1986553396 @default.
- W2007086780 cites W1988255658 @default.
- W2007086780 cites W1989425514 @default.
- W2007086780 cites W1992232200 @default.
- W2007086780 cites W1992588394 @default.
- W2007086780 cites W1994404690 @default.
- W2007086780 cites W1999003781 @default.
- W2007086780 cites W1999097194 @default.
- W2007086780 cites W2000164429 @default.
- W2007086780 cites W2000370325 @default.
- W2007086780 cites W2002217048 @default.
- W2007086780 cites W2002603957 @default.
- W2007086780 cites W2003219159 @default.
- W2007086780 cites W2003227164 @default.
- W2007086780 cites W2006919298 @default.
- W2007086780 cites W2007256796 @default.
- W2007086780 cites W2007628346 @default.
- W2007086780 cites W2008865320 @default.
- W2007086780 cites W2009899161 @default.
- W2007086780 cites W2010589798 @default.
- W2007086780 cites W2011128355 @default.
- W2007086780 cites W2011261850 @default.
- W2007086780 cites W2014374424 @default.
- W2007086780 cites W2019030973 @default.
- W2007086780 cites W2021008545 @default.
- W2007086780 cites W2023746875 @default.
- W2007086780 cites W2023843372 @default.
- W2007086780 cites W2024149997 @default.
- W2007086780 cites W2027595726 @default.
- W2007086780 cites W2028336700 @default.
- W2007086780 cites W2028539126 @default.
- W2007086780 cites W2028861996 @default.
- W2007086780 cites W2030260422 @default.
- W2007086780 cites W2031206118 @default.
- W2007086780 cites W2031782903 @default.
- W2007086780 cites W2031964267 @default.
- W2007086780 cites W2032080946 @default.
- W2007086780 cites W2034842641 @default.
- W2007086780 cites W2035651986 @default.
- W2007086780 cites W2037247242 @default.
- W2007086780 cites W2038031211 @default.
- W2007086780 cites W2039733501 @default.
- W2007086780 cites W2042200046 @default.
- W2007086780 cites W2042784771 @default.
- W2007086780 cites W2044501765 @default.
- W2007086780 cites W2045132607 @default.
- W2007086780 cites W2045404157 @default.
- W2007086780 cites W2047048276 @default.
- W2007086780 cites W2047394544 @default.
- W2007086780 cites W2047433615 @default.