FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007092039> ?p ?o ?g. }

• W2007092039 endingPage "1033" @default.
• W2007092039 startingPage "1025" @default.
• W2007092039 abstract "Eugenol (compound 1 in Fig. 1, 4-allyl-2-methyoxyphenol) and isoeugenol (compound 2 in Fig. 1, 4-propenyl-2-methoxyphenol), both used as a flavor agent in cosmetic and food products, have both prooxidant and antioxidant activities. Their adverse effects such as allergic and inflammatory reaction may be due to their prooxidant activity. To clarify the mechanisms of their cytotoxicity and the factors affecting their antioxidant/prooxidant activities, we investigated the cytotoxicity, ROS production, and cellular glutathione (GSH) levels induced by eugenol and isoeugenol in a human submandibular cell line. The cytotoxicity (MTT method) of eugenol was 1 order of magnitude lower than that of isoeugenol (CC50: eugenol, 0.395 mM; isoeugenol, 0.0523 mM); and ROS production (CDF staining) was induced significantly by isoeugenol, but not by eugenol. Under treatment with H2O2 (100 μM) plus horseradish peroxidase (1 μg/ml) for 30 min or with visible light irradiation for 5 min, eugenol caused biphasic ROS production characterized by enhanced at lower eugenol concentrations (5–10 μM) and decreased at higher concentrations (500 μM). In contrast, isoeugenol enhanced ROS production over a wide range of concentrations (5–500 μM). Isoeugenol at 1000 μM significantly reduced GSH levels compared with eugenol at the same concentration. The high cytotoxicity of isoeugenol may be attributed to its induction of high ROS production and low GSH levels, possibly as a result of benzyl radical formation. In contrast, the cytotoxicity of eugenol is likely to be mediated by ROS-independent mechanisms, possibly involving phenoxyl radicals and/or eugenol quinone methide." @default.
• W2007092039 created "2016-06-24" @default.
• W2007092039 creator A5013049607 @default.
• W2007092039 creator A5064723525 @default.
• W2007092039 creator A5070990441 @default.
• W2007092039 date "2005-12-01" @default.
• W2007092039 modified "2023-10-11" @default.
• W2007092039 title "A comparative study of the antioxidant/prooxidant activities of eugenol and isoeugenol with various concentrations and oxidation conditions" @default.
• W2007092039 cites W1538291123 @default.
• W2007092039 cites W1577248302 @default.
• W2007092039 cites W1967643352 @default.
• W2007092039 cites W1975962913 @default.
• W2007092039 cites W1987480112 @default.
• W2007092039 cites W1998640751 @default.
• W2007092039 cites W1999358524 @default.
• W2007092039 cites W2002746961 @default.
• W2007092039 cites W2003081881 @default.
• W2007092039 cites W2006421463 @default.
• W2007092039 cites W2026057401 @default.
• W2007092039 cites W2029928510 @default.
• W2007092039 cites W2035482536 @default.
• W2007092039 cites W2038661189 @default.
• W2007092039 cites W2051342685 @default.
• W2007092039 cites W2068703422 @default.
• W2007092039 cites W2069466168 @default.
• W2007092039 cites W2071356759 @default.
• W2007092039 cites W2084316579 @default.
• W2007092039 cites W2088732554 @default.
• W2007092039 cites W2088827024 @default.
• W2007092039 cites W2101537600 @default.
• W2007092039 cites W2110346321 @default.
• W2007092039 cites W2113999599 @default.
• W2007092039 cites W2114918609 @default.
• W2007092039 cites W2118609819 @default.
• W2007092039 cites W2121694020 @default.
• W2007092039 cites W2141246998 @default.
• W2007092039 cites W2146836738 @default.
• W2007092039 cites W2153486676 @default.
• W2007092039 doi "https://doi.org/10.1016/j.tiv.2005.04.012" @default.
• W2007092039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15964168" @default.
• W2007092039 hasPublicationYear "2005" @default.
• W2007092039 type Work @default.
• W2007092039 sameAs 2007092039 @default.
• W2007092039 citedByCount "118" @default.
• W2007092039 countsByYear W20070920392012 @default.
• W2007092039 countsByYear W20070920392013 @default.
• W2007092039 countsByYear W20070920392014 @default.
• W2007092039 countsByYear W20070920392015 @default.
• W2007092039 countsByYear W20070920392016 @default.
• W2007092039 countsByYear W20070920392017 @default.
• W2007092039 countsByYear W20070920392018 @default.
• W2007092039 countsByYear W20070920392019 @default.
• W2007092039 countsByYear W20070920392020 @default.
• W2007092039 countsByYear W20070920392021 @default.
• W2007092039 countsByYear W20070920392022 @default.
• W2007092039 countsByYear W20070920392023 @default.
• W2007092039 crossrefType "journal-article" @default.
• W2007092039 hasAuthorship W2007092039A5013049607 @default.
• W2007092039 hasAuthorship W2007092039A5064723525 @default.
• W2007092039 hasAuthorship W2007092039A5070990441 @default.
• W2007092039 hasConcept C109316439 @default.
• W2007092039 hasConcept C178790620 @default.
• W2007092039 hasConcept C181199279 @default.
• W2007092039 hasConcept C185592680 @default.
• W2007092039 hasConcept C202751555 @default.
• W2007092039 hasConcept C2778004101 @default.
• W2007092039 hasConcept C2780028989 @default.
• W2007092039 hasConcept C2780470866 @default.
• W2007092039 hasConcept C538909803 @default.
• W2007092039 hasConcept C55493867 @default.
• W2007092039 hasConceptScore W2007092039C109316439 @default.
• W2007092039 hasConceptScore W2007092039C178790620 @default.
• W2007092039 hasConceptScore W2007092039C181199279 @default.
• W2007092039 hasConceptScore W2007092039C185592680 @default.
• W2007092039 hasConceptScore W2007092039C202751555 @default.
• W2007092039 hasConceptScore W2007092039C2778004101 @default.
• W2007092039 hasConceptScore W2007092039C2780028989 @default.
• W2007092039 hasConceptScore W2007092039C2780470866 @default.
• W2007092039 hasConceptScore W2007092039C538909803 @default.
• W2007092039 hasConceptScore W2007092039C55493867 @default.
• W2007092039 hasIssue "8" @default.
• W2007092039 hasLocation W20070920391 @default.
• W2007092039 hasLocation W20070920392 @default.
• W2007092039 hasOpenAccess W2007092039 @default.
• W2007092039 hasPrimaryLocation W20070920391 @default.
• W2007092039 hasRelatedWork W1977766026 @default.
• W2007092039 hasRelatedWork W2005330982 @default.
• W2007092039 hasRelatedWork W2038011849 @default.
• W2007092039 hasRelatedWork W2184945869 @default.
• W2007092039 hasRelatedWork W2236096485 @default.
• W2007092039 hasRelatedWork W2598767260 @default.
• W2007092039 hasRelatedWork W2738809237 @default.
• W2007092039 hasRelatedWork W2747409465 @default.
• W2007092039 hasRelatedWork W2790399356 @default.
• W2007092039 hasRelatedWork W2395350541 @default.
• W2007092039 hasVolume "19" @default.
• W2007092039 isParatext "false" @default.
• W2007092039 isRetracted "false" @default.

• next