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- W2007095775 abstract "A wide variety of in vivo manipulations influence neurogenesis in the adult hippocampus. It is not known, however, if adult neural stem/progenitor cells (NPCs) can intrinsically sense excitatory neural activity and thereby implement a direct coupling between excitation and neurogenesis. Moreover, the theoretical significance of activity-dependent neurogenesis in hippocampal-type memory processing networks has not been explored. Here we demonstrate that excitatory stimuli act directly on adult hippocampal NPCs to favor neuron production. The excitation is sensed via Cav1.2/1.3 (L-type) Ca2+ channels and NMDA receptors on the proliferating precursors. Excitation through this pathway acts to inhibit expression of the glial fate genes Hes1 and Id2 and increase expression of NeuroD, a positive regulator of neuronal differentiation. These activity-sensing properties of the adult NPCs, when applied as an “excitation-neurogenesis coupling rule” within a Hebbian neural network, predict significant advantages for both the temporary storage and the clearance of memories." @default.
- W2007095775 created "2016-06-24" @default.
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- W2007095775 date "2004-05-01" @default.
- W2007095775 modified "2023-10-12" @default.
- W2007095775 title "Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells" @default.
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- W2007095775 doi "https://doi.org/10.1016/s0896-6273(04)00266-1" @default.
- W2007095775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15157417" @default.
- W2007095775 hasPublicationYear "2004" @default.
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