Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007102547> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2007102547 abstract "The effects of non-steroid antiinflammatory (NSAI) drugs on the rectal membrane were studied by measuring the change in the rectal absorption of ampicillin and cephalothin. All the NSAI drugs studied were found to case a remarkable enhancement of the rectal absorption of antibiotics which were not able to permeate readily through the rectal membrane in the absence of NSAI drugs. The optimum concentrations of NSAI drugs as adjuvants in triglyceride suppositories containing 10% ampicillin sodium were 1.5% for indomethacin sodium and diclofenac sodium, 5% for mepirizole, 7.5% for phenylbutazone, and 10% for sodium salicylate. These concentrations of NSAI drugs were used in a study of the promoting efficacy of the drugs as adjuvants for the rectal absorption of antibiotics. The promoting effects of adjuvants in dogs were inferior to those in rabbits. From simultaneous measurements of NSAI drugs and antibiotic, it was found that the absorption of antibiotic started at the early stages after the administration of suppositories and the peak blood level was reached while the blood concentration of NSAI drug was still increasing. From these results, it was suggested that the NSAI drugs made the mucosal barrier leaky to water-soluble antibiotics at the early stages of permeation of the NSAI drugs through the rectal membrane, and that the barrier rapidly recovered its normal properties even while the permeation of NSAI drug was continuing and a considerable amount of antibiotic still remained in the rectal cavity. Alinear correlation between the enhanced absorption of antibiotics and the antiinflammatory activity of NSAI drugs against carrageenan-induced edema was observed." @default.
- W2007102547 created "2016-06-24" @default.
- W2007102547 creator A5017030730 @default.
- W2007102547 creator A5023818851 @default.
- W2007102547 creator A5032256813 @default.
- W2007102547 creator A5039978322 @default.
- W2007102547 creator A5046758241 @default.
- W2007102547 creator A5087854831 @default.
- W2007102547 date "1981-01-01" @default.
- W2007102547 modified "2023-10-16" @default.
- W2007102547 title "Rectal delivery of antiinflammatory drugs. I. The influence of antiinflammatory drugs on rectal absorption of .BETA.-lactam antibiotics." @default.
- W2007102547 doi "https://doi.org/10.1248/cpb.29.2974" @default.
- W2007102547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7318027" @default.
- W2007102547 hasPublicationYear "1981" @default.
- W2007102547 type Work @default.
- W2007102547 sameAs 2007102547 @default.
- W2007102547 citedByCount "28" @default.
- W2007102547 crossrefType "journal-article" @default.
- W2007102547 hasAuthorship W2007102547A5017030730 @default.
- W2007102547 hasAuthorship W2007102547A5023818851 @default.
- W2007102547 hasAuthorship W2007102547A5032256813 @default.
- W2007102547 hasAuthorship W2007102547A5039978322 @default.
- W2007102547 hasAuthorship W2007102547A5046758241 @default.
- W2007102547 hasAuthorship W2007102547A5087854831 @default.
- W2007102547 hasBestOaLocation W20071025471 @default.
- W2007102547 hasConcept C112705442 @default.
- W2007102547 hasConcept C121332964 @default.
- W2007102547 hasConcept C125287762 @default.
- W2007102547 hasConcept C185592680 @default.
- W2007102547 hasConcept C24890656 @default.
- W2007102547 hasConcept C2776873419 @default.
- W2007102547 hasConcept C2779826273 @default.
- W2007102547 hasConcept C2780035454 @default.
- W2007102547 hasConcept C2908765736 @default.
- W2007102547 hasConcept C43617362 @default.
- W2007102547 hasConcept C501593827 @default.
- W2007102547 hasConcept C55493867 @default.
- W2007102547 hasConcept C71924100 @default.
- W2007102547 hasConcept C98274493 @default.
- W2007102547 hasConceptScore W2007102547C112705442 @default.
- W2007102547 hasConceptScore W2007102547C121332964 @default.
- W2007102547 hasConceptScore W2007102547C125287762 @default.
- W2007102547 hasConceptScore W2007102547C185592680 @default.
- W2007102547 hasConceptScore W2007102547C24890656 @default.
- W2007102547 hasConceptScore W2007102547C2776873419 @default.
- W2007102547 hasConceptScore W2007102547C2779826273 @default.
- W2007102547 hasConceptScore W2007102547C2780035454 @default.
- W2007102547 hasConceptScore W2007102547C2908765736 @default.
- W2007102547 hasConceptScore W2007102547C43617362 @default.
- W2007102547 hasConceptScore W2007102547C501593827 @default.
- W2007102547 hasConceptScore W2007102547C55493867 @default.
- W2007102547 hasConceptScore W2007102547C71924100 @default.
- W2007102547 hasConceptScore W2007102547C98274493 @default.
- W2007102547 hasLocation W20071025471 @default.
- W2007102547 hasLocation W20071025472 @default.
- W2007102547 hasOpenAccess W2007102547 @default.
- W2007102547 hasPrimaryLocation W20071025471 @default.
- W2007102547 hasRelatedWork W2015262479 @default.
- W2007102547 hasRelatedWork W2068607115 @default.
- W2007102547 hasRelatedWork W2071152301 @default.
- W2007102547 hasRelatedWork W2091365486 @default.
- W2007102547 hasRelatedWork W2150324357 @default.
- W2007102547 hasRelatedWork W2181288174 @default.
- W2007102547 hasRelatedWork W2329107126 @default.
- W2007102547 hasRelatedWork W2375805389 @default.
- W2007102547 hasRelatedWork W2951518585 @default.
- W2007102547 hasRelatedWork W4242392754 @default.
- W2007102547 isParatext "false" @default.
- W2007102547 isRetracted "false" @default.
- W2007102547 magId "2007102547" @default.
- W2007102547 workType "article" @default.