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- W2007102617 abstract "Objective: To determine if there is a dose–response curve for TGF-β1 in a rabbit calvarial defect model. Study Design: Controlled animal study using arms of increasing concentrations of TGF-β1 to evaluate the osteoinductive potential of each arm. Methods: Sixteen skeletally mature New Zealand white rabbits were randomized into control and experimental arms. Incremental doses of TGF-β1 delivered in an inactivated guanidine-extracted demineralized bone matrix (Gu-DBM) carrier were implanted into a critically sized calvarial defect. The animals were sacrificed at 4 weeks and histomorphometric analysis was then accomplished. Results: TGF-β1 showed a dose–response relationship, with the higher doses chosen for this study causing more robust osteoinduction. Conclusions: In this pilot dosing study, TGF-β1 demonstrates increasing osteoinduction with increasing dose levels in this animal model. Laryngoscope, 119:126–130, 2009" @default.
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- W2007102617 date "2009-01-01" @default.
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- W2007102617 title "Transforming growth factor-β1 shows an incremental osteoinductive dose-response relationship" @default.
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- W2007102617 doi "https://doi.org/10.1002/lary.20009" @default.
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