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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007103196> ?p ?o ?g. }

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• W2007103196 abstract "Herein, we show that sansalvamide A-amide (San A-amide), a structurally unique molecule, influences a subset of cancer-related pathways involving heat shock protein 90 (Hsp90). We show that San A-amide specifically binds to the N-middle domain of Hsp90 and allosterically disrupts the binding of proteins thought to interact with the Hsp90 C-terminal domain, while having no effect on an N-terminal domain client protein. This unique mechanism suggests that San A-amide is a potential tool for studying C-terminal binding proteins of Hsp90 as well as a promising lead in the development of new cancer therapeutics." @default.
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• W2007103196 date "2010-01-04" @default.
• W2007103196 modified "2023-10-06" @default.
• W2007103196 title "Mechanistic Studies of Sansalvamide A-Amide: An Allosteric Modulator of Hsp90" @default.
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• W2007103196 doi "https://doi.org/10.1021/ml900003t" @default.
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