Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007103296> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2007103296 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCIn order to achieve improved resection of disseminated cancer we used a telomerase-specific replicating adenovirus expressing GFP (OBP-401, Telomelysin®-GFP) to label tumors in vivo. Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of telomerase which is highly active in cancer cells but quiescent in most normal cells. OBP-401 contains the replication cassette, in which the hTERT promoter element drives expression of E1 genes and the GFP gene. Therefore, OBP-401 can selectively replicate in and label tumor cells with GFP. We previously demonstrated that in a peritoneal carcinomatosis mouse model of colon cancer, OBP-401 administration specifically labeled tumor cells in vivo with GFP fluorescence and enabled fluorescence-guided surgical navigation (Proc. Natl. Acad. Sci. USA, 1-6, 14514-14517, 2009; Molecular Cancer Therapeutics 8, 3001-3008, 2009). However, technical difficulties in removing microscopic tumors still remained to be solved since tumor could recur after fluorescence-guided resection. In the present study, we report an additional use of OBP-401 for surgical cure of cancer. Several weeks after cytoreduction surgery with OBP-401 GFP labeling, recurrent tumor tissues were also observed by GFP expression which could be resected under fluorescence guidance. These results indicate that OBP-401 treatment enabled fluorescent detection of subsequent recurrence after cancer surgery for the potential cure of early recurrence. The results suggest future human use of OBP-401 in cancer surgery.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3388." @default.
- W2007103296 created "2016-06-24" @default.
- W2007103296 creator A5009960666 @default.
- W2007103296 creator A5029076256 @default.
- W2007103296 creator A5035456514 @default.
- W2007103296 creator A5040819666 @default.
- W2007103296 creator A5068717107 @default.
- W2007103296 date "2010-04-15" @default.
- W2007103296 modified "2023-09-25" @default.
- W2007103296 title "Abstract 3388: Selective GFP labeling of disseminated cancer with a telomerase-specific adenovirus (OBP-401) to report recurrence after resection" @default.
- W2007103296 doi "https://doi.org/10.1158/1538-7445.am10-3388" @default.
- W2007103296 hasPublicationYear "2010" @default.
- W2007103296 type Work @default.
- W2007103296 sameAs 2007103296 @default.
- W2007103296 citedByCount "0" @default.
- W2007103296 crossrefType "proceedings-article" @default.
- W2007103296 hasAuthorship W2007103296A5009960666 @default.
- W2007103296 hasAuthorship W2007103296A5029076256 @default.
- W2007103296 hasAuthorship W2007103296A5035456514 @default.
- W2007103296 hasAuthorship W2007103296A5040819666 @default.
- W2007103296 hasAuthorship W2007103296A5068717107 @default.
- W2007103296 hasConcept C104317684 @default.
- W2007103296 hasConcept C121608353 @default.
- W2007103296 hasConcept C125593758 @default.
- W2007103296 hasConcept C126322002 @default.
- W2007103296 hasConcept C142613039 @default.
- W2007103296 hasConcept C207001950 @default.
- W2007103296 hasConcept C502942594 @default.
- W2007103296 hasConcept C54355233 @default.
- W2007103296 hasConcept C71924100 @default.
- W2007103296 hasConcept C86803240 @default.
- W2007103296 hasConcept C94581717 @default.
- W2007103296 hasConcept C96232424 @default.
- W2007103296 hasConceptScore W2007103296C104317684 @default.
- W2007103296 hasConceptScore W2007103296C121608353 @default.
- W2007103296 hasConceptScore W2007103296C125593758 @default.
- W2007103296 hasConceptScore W2007103296C126322002 @default.
- W2007103296 hasConceptScore W2007103296C142613039 @default.
- W2007103296 hasConceptScore W2007103296C207001950 @default.
- W2007103296 hasConceptScore W2007103296C502942594 @default.
- W2007103296 hasConceptScore W2007103296C54355233 @default.
- W2007103296 hasConceptScore W2007103296C71924100 @default.
- W2007103296 hasConceptScore W2007103296C86803240 @default.
- W2007103296 hasConceptScore W2007103296C94581717 @default.
- W2007103296 hasConceptScore W2007103296C96232424 @default.
- W2007103296 hasLocation W20071032961 @default.
- W2007103296 hasOpenAccess W2007103296 @default.
- W2007103296 hasPrimaryLocation W20071032961 @default.
- W2007103296 hasRelatedWork W1558453863 @default.
- W2007103296 hasRelatedWork W1906833049 @default.
- W2007103296 hasRelatedWork W1975571606 @default.
- W2007103296 hasRelatedWork W1994302706 @default.
- W2007103296 hasRelatedWork W2003635897 @default.
- W2007103296 hasRelatedWork W2005564524 @default.
- W2007103296 hasRelatedWork W2023965328 @default.
- W2007103296 hasRelatedWork W2033235018 @default.
- W2007103296 hasRelatedWork W2037679647 @default.
- W2007103296 hasRelatedWork W2044945309 @default.
- W2007103296 hasRelatedWork W2050349145 @default.
- W2007103296 hasRelatedWork W2094101833 @default.
- W2007103296 hasRelatedWork W2151262467 @default.
- W2007103296 hasRelatedWork W2160107647 @default.
- W2007103296 hasRelatedWork W2168261379 @default.
- W2007103296 hasRelatedWork W2246303264 @default.
- W2007103296 hasRelatedWork W2316810636 @default.
- W2007103296 hasRelatedWork W2419617127 @default.
- W2007103296 hasRelatedWork W3008697658 @default.
- W2007103296 hasRelatedWork W2123308678 @default.
- W2007103296 isParatext "false" @default.
- W2007103296 isRetracted "false" @default.
- W2007103296 magId "2007103296" @default.
- W2007103296 workType "article" @default.