FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007103510> ?p ?o ?g. }

• W2007103510 endingPage "693" @default.
• W2007103510 startingPage "688" @default.
• W2007103510 abstract "Previous studies have shown that self-antigens overexpressed in malignant tissue can provide a basis for a tumor-specific immune response. The mucin MUC2 is strongly overexpressed in all mucinous tumors of colon, breast, ovary and pancreas. In the corresponding normal tissue it is either not expressed (breast, ovary, pancreas) or it is expressed at considerably lower levels than in the mucinous tumors (colon). We therefore investigated whether the MUC2 molecule comprises HLA-A2-binding epitopes recognized by human cytotoxic T cells. Four MUC2 peptides with high affinity and stable binding to HLA-A2 were identified. Those peptides and additionally 3 peptides with moderate binding to HLA-A2 were loaded onto dendritic cells, which were used for stimulation of autologous T cells from healthy donors. Two MUC2 peptides, which belonged to the group of stable binders, induced specific cytotoxic T-cell lines. Target cells loaded with these peptides were strongly lysed in a concentration-dependent and HLA-A2-restricted manner. Our data show that the tumor-associated mucin MUC2 has potential as a target antigen for cytotoxic T cells in patients with mucinous carcinomas. Int. J. Cancer 75:688–693, 1998.© 1998 Wiley-Liss, Inc." @default.
• W2007103510 created "2016-06-24" @default.
• W2007103510 creator A5010138668 @default.
• W2007103510 creator A5014793533 @default.
• W2007103510 creator A5020881329 @default.
• W2007103510 creator A5035949087 @default.
• W2007103510 creator A5038528339 @default.
• W2007103510 creator A5041817328 @default.
• W2007103510 creator A5076880013 @default.
• W2007103510 creator A5090153362 @default.
• W2007103510 date "1998-03-02" @default.
• W2007103510 modified "2023-10-17" @default.
• W2007103510 title "Identification of HLA-A2-restricted epitopes of the tumor-associated antigen MUC2 recognized by human cytotoxic T cells" @default.
• W2007103510 cites W1487106910 @default.
• W2007103510 cites W2006362004 @default.
• W2007103510 cites W2009870709 @default.
• W2007103510 cites W2033537986 @default.
• W2007103510 cites W2049472927 @default.
• W2007103510 cites W2052912081 @default.
• W2007103510 cites W2080692751 @default.
• W2007103510 cites W2083753580 @default.
• W2007103510 cites W2084323507 @default.
• W2007103510 cites W2111049305 @default.
• W2007103510 cites W2116293732 @default.
• W2007103510 cites W2122507780 @default.
• W2007103510 cites W2127468351 @default.
• W2007103510 cites W2131761283 @default.
• W2007103510 cites W2135808990 @default.
• W2007103510 cites W2142066580 @default.
• W2007103510 cites W2145136557 @default.
• W2007103510 cites W2149940155 @default.
• W2007103510 cites W2154695589 @default.
• W2007103510 cites W2155323589 @default.
• W2007103510 cites W4237971935 @default.
• W2007103510 cites W572161398 @default.
• W2007103510 doi "https://doi.org/10.1002/(sici)1097-0215(19980302)75:5<688::aid-ijc5>3.0.co;2-v" @default.
• W2007103510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9495235" @default.
• W2007103510 hasPublicationYear "1998" @default.
• W2007103510 type Work @default.
• W2007103510 sameAs 2007103510 @default.
• W2007103510 citedByCount "20" @default.
• W2007103510 countsByYear W20071035102013 @default.
• W2007103510 countsByYear W20071035102014 @default.
• W2007103510 crossrefType "journal-article" @default.
• W2007103510 hasAuthorship W2007103510A5010138668 @default.
• W2007103510 hasAuthorship W2007103510A5014793533 @default.
• W2007103510 hasAuthorship W2007103510A5020881329 @default.
• W2007103510 hasAuthorship W2007103510A5035949087 @default.
• W2007103510 hasAuthorship W2007103510A5038528339 @default.
• W2007103510 hasAuthorship W2007103510A5041817328 @default.
• W2007103510 hasAuthorship W2007103510A5076880013 @default.
• W2007103510 hasAuthorship W2007103510A5090153362 @default.
• W2007103510 hasBestOaLocation W20071035101 @default.
• W2007103510 hasConcept C121608353 @default.
• W2007103510 hasConcept C147483822 @default.
• W2007103510 hasConcept C153911025 @default.
• W2007103510 hasConcept C154317977 @default.
• W2007103510 hasConcept C179264091 @default.
• W2007103510 hasConcept C188280979 @default.
• W2007103510 hasConcept C195616568 @default.
• W2007103510 hasConcept C202751555 @default.
• W2007103510 hasConcept C203014093 @default.
• W2007103510 hasConcept C2778764654 @default.
• W2007103510 hasConcept C2780427987 @default.
• W2007103510 hasConcept C502942594 @default.
• W2007103510 hasConcept C54355233 @default.
• W2007103510 hasConcept C55493867 @default.
• W2007103510 hasConcept C86803240 @default.
• W2007103510 hasConcept C8891405 @default.
• W2007103510 hasConceptScore W2007103510C121608353 @default.
• W2007103510 hasConceptScore W2007103510C147483822 @default.
• W2007103510 hasConceptScore W2007103510C153911025 @default.
• W2007103510 hasConceptScore W2007103510C154317977 @default.
• W2007103510 hasConceptScore W2007103510C179264091 @default.
• W2007103510 hasConceptScore W2007103510C188280979 @default.
• W2007103510 hasConceptScore W2007103510C195616568 @default.
• W2007103510 hasConceptScore W2007103510C202751555 @default.
• W2007103510 hasConceptScore W2007103510C203014093 @default.
• W2007103510 hasConceptScore W2007103510C2778764654 @default.
• W2007103510 hasConceptScore W2007103510C2780427987 @default.
• W2007103510 hasConceptScore W2007103510C502942594 @default.
• W2007103510 hasConceptScore W2007103510C54355233 @default.
• W2007103510 hasConceptScore W2007103510C55493867 @default.
• W2007103510 hasConceptScore W2007103510C86803240 @default.
• W2007103510 hasConceptScore W2007103510C8891405 @default.
• W2007103510 hasIssue "5" @default.
• W2007103510 hasLocation W20071035101 @default.
• W2007103510 hasLocation W20071035102 @default.
• W2007103510 hasOpenAccess W2007103510 @default.
• W2007103510 hasPrimaryLocation W20071035101 @default.
• W2007103510 hasRelatedWork W1965116372 @default.
• W2007103510 hasRelatedWork W2001280522 @default.
• W2007103510 hasRelatedWork W2008949385 @default.
• W2007103510 hasRelatedWork W2037082443 @default.
• W2007103510 hasRelatedWork W2060246599 @default.
• W2007103510 hasRelatedWork W2092720945 @default.
• W2007103510 hasRelatedWork W2156809136 @default.
• W2007103510 hasRelatedWork W2220102944 @default.

• next