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• W2007103582 endingPage "2684" @default.
• W2007103582 startingPage "2671" @default.
• W2007103582 abstract "Genetic changes through allelic loss and nucleic acid or protein modifications are the main contributors to loss of function of tumor suppressor proteins. In particular, epigenetic silencing of genes by promoter hypermethylation is associated with increased tumor severity and poor survival. The RASSF (Ras association domain family) family of proteins consists of 10 members, many of which are tumor suppressor proteins that undergo loss of expression through promoter methylation in numerous types of cancers such as leukemia, melanoma, breast, prostate, neck, lung, brain, colorectal and kidney cancers. In addition to their tumor suppressor function, RASSF proteins act as scaffolding agents in microtubule stability, regulate mitotic cell division, modulate apoptosis, control cell migration and cell adhesion, and modulate NFκB activity and the duration of inflammation. The ubiquitous functions of these proteins highlight their importance in numerous physiological pathways. In this review, we will focus on the biological roles of the RASSF family members and their regulation." @default.
• W2007103582 created "2016-06-24" @default.
• W2007103582 creator A5033798282 @default.
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• W2007103582 creator A5055539104 @default.
• W2007103582 creator A5056120914 @default.
• W2007103582 creator A5057676686 @default.
• W2007103582 date "2014-03-04" @default.
• W2007103582 modified "2023-10-18" @default.
• W2007103582 title "RASSF tumor suppressor gene family: Biological functions and regulation" @default.
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