Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007104538> ?p ?o ?g. }
- W2007104538 endingPage "180" @default.
- W2007104538 startingPage "174" @default.
- W2007104538 abstract "The microsomal fraction was extracted from the livers of a group of burned rats and a control group of unburned rats. Morphologically, this fraction corresponds to the endoplasmic reticulum membranes and is the site of the microsomal oxidative system which catalyzes numerous metabolic reactions fundamental to the detoxifying activity of the liver. Cytochrome P-450 is the terminal oxidase of the microsomal respiratory chain and it is also the haemo-protein present in the largest quantity in the microsomal fraction. Its activity is usually reflected by alterations in the biological equilibrium of its two forms (reduced and oxidized). In fact, after a burn injury, especially after 6 h, there is a modification in the cytochrome auto-oxidability as is shown by the marked increase in the NADPH-reducible fraction. The accompanying increase of the total cytochrome P-450 concentration may be due to a formation de novo and/or to a redistribution of the two different pools of cytochrome normally present. In this study, the changes in the ultrastructure of liver cells and the time course of changes in the levels of microsomal P-450 are described in detail. P-450 levels changed immediately post burn but returned to normal levels 24 h later. They could confirm the hypothesis that in a burn injury there is a ‘factor’ acting by a toxic mechanism; such a factor, newly formed or present as a precursor and activated by the burn, could damage the liver, or better, activate its detoxifying mechanism even in the early hours post burn." @default.
- W2007104538 created "2016-06-24" @default.
- W2007104538 creator A5050059180 @default.
- W2007104538 creator A5052819175 @default.
- W2007104538 creator A5053191551 @default.
- W2007104538 creator A5089371735 @default.
- W2007104538 date "1980-03-01" @default.
- W2007104538 modified "2023-10-18" @default.
- W2007104538 title "Changes in cytochrome P-450 levels in hepatic microsomes after burn injuries: experimental study" @default.
- W2007104538 cites W1494705713 @default.
- W2007104538 cites W1775964807 @default.
- W2007104538 cites W1976673312 @default.
- W2007104538 cites W1977153510 @default.
- W2007104538 cites W1981705557 @default.
- W2007104538 cites W1983497488 @default.
- W2007104538 cites W1985518706 @default.
- W2007104538 cites W1997793471 @default.
- W2007104538 cites W1998373321 @default.
- W2007104538 cites W2029385650 @default.
- W2007104538 cites W2032176942 @default.
- W2007104538 cites W2034548569 @default.
- W2007104538 cites W2055079549 @default.
- W2007104538 cites W2063686236 @default.
- W2007104538 cites W2064906787 @default.
- W2007104538 cites W2068115402 @default.
- W2007104538 cites W2074100239 @default.
- W2007104538 cites W2081205552 @default.
- W2007104538 cites W2091244982 @default.
- W2007104538 cites W2130993954 @default.
- W2007104538 cites W2294071862 @default.
- W2007104538 cites W2396266917 @default.
- W2007104538 cites W2401066369 @default.
- W2007104538 cites W2403706791 @default.
- W2007104538 cites W2414095779 @default.
- W2007104538 cites W2464406652 @default.
- W2007104538 cites W2473899844 @default.
- W2007104538 cites W2596217884 @default.
- W2007104538 cites W2893863478 @default.
- W2007104538 cites W635236374 @default.
- W2007104538 doi "https://doi.org/10.1016/0305-4179(80)90062-5" @default.
- W2007104538 hasPublicationYear "1980" @default.
- W2007104538 type Work @default.
- W2007104538 sameAs 2007104538 @default.
- W2007104538 citedByCount "1" @default.
- W2007104538 crossrefType "journal-article" @default.
- W2007104538 hasAuthorship W2007104538A5050059180 @default.
- W2007104538 hasAuthorship W2007104538A5052819175 @default.
- W2007104538 hasAuthorship W2007104538A5053191551 @default.
- W2007104538 hasAuthorship W2007104538A5089371735 @default.
- W2007104538 hasConcept C123249941 @default.
- W2007104538 hasConcept C126322002 @default.
- W2007104538 hasConcept C134018914 @default.
- W2007104538 hasConcept C141071460 @default.
- W2007104538 hasConcept C158617107 @default.
- W2007104538 hasConcept C181199279 @default.
- W2007104538 hasConcept C2780768313 @default.
- W2007104538 hasConcept C28859421 @default.
- W2007104538 hasConcept C29311851 @default.
- W2007104538 hasConcept C2993242423 @default.
- W2007104538 hasConcept C38485361 @default.
- W2007104538 hasConcept C55493867 @default.
- W2007104538 hasConcept C57600042 @default.
- W2007104538 hasConcept C71924100 @default.
- W2007104538 hasConcept C86803240 @default.
- W2007104538 hasConcept C87644729 @default.
- W2007104538 hasConceptScore W2007104538C123249941 @default.
- W2007104538 hasConceptScore W2007104538C126322002 @default.
- W2007104538 hasConceptScore W2007104538C134018914 @default.
- W2007104538 hasConceptScore W2007104538C141071460 @default.
- W2007104538 hasConceptScore W2007104538C158617107 @default.
- W2007104538 hasConceptScore W2007104538C181199279 @default.
- W2007104538 hasConceptScore W2007104538C2780768313 @default.
- W2007104538 hasConceptScore W2007104538C28859421 @default.
- W2007104538 hasConceptScore W2007104538C29311851 @default.
- W2007104538 hasConceptScore W2007104538C2993242423 @default.
- W2007104538 hasConceptScore W2007104538C38485361 @default.
- W2007104538 hasConceptScore W2007104538C55493867 @default.
- W2007104538 hasConceptScore W2007104538C57600042 @default.
- W2007104538 hasConceptScore W2007104538C71924100 @default.
- W2007104538 hasConceptScore W2007104538C86803240 @default.
- W2007104538 hasConceptScore W2007104538C87644729 @default.
- W2007104538 hasIssue "3" @default.
- W2007104538 hasLocation W20071045381 @default.
- W2007104538 hasOpenAccess W2007104538 @default.
- W2007104538 hasPrimaryLocation W20071045381 @default.
- W2007104538 hasRelatedWork W1809909068 @default.
- W2007104538 hasRelatedWork W1826167165 @default.
- W2007104538 hasRelatedWork W1970761312 @default.
- W2007104538 hasRelatedWork W1973396465 @default.
- W2007104538 hasRelatedWork W2065253029 @default.
- W2007104538 hasRelatedWork W2345336362 @default.
- W2007104538 hasRelatedWork W2412847724 @default.
- W2007104538 hasRelatedWork W2425441172 @default.
- W2007104538 hasRelatedWork W2614188077 @default.
- W2007104538 hasRelatedWork W3036202779 @default.
- W2007104538 hasVolume "6" @default.
- W2007104538 isParatext "false" @default.
- W2007104538 isRetracted "false" @default.