FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007111488> ?p ?o ?g. }

• W2007111488 endingPage "137" @default.
• W2007111488 startingPage "129" @default.
• W2007111488 abstract "Gene expression profiling may be used to stratify patients by disease severity to test the hypothesis that variable disease outcome has a genetic component. In order to define unique expression signatures in African American rheumatoid arthritis (RA) patients with severe erosive disease, we undertook a gene expression study using samples of RNA from peripheral blood mononuclear cells (PBMCs). RNA from baseline PBMC samples of 96 African American RA patients with early RA (<2 years disease duration) was hybridized to cDNA probes of the Illumina Human HT-V3 expression array. Expression analyses were performed using the ca. 25,000 cDNA probes, and then expression levels were compared to the total number of erosions in radiographs of the hands and feet at baseline and 36 months. Using a false discovery rate cutoff of Q = 0.30, 1,138 genes at baseline and 680 genes at 36 months significantly correlated with total erosions. No evidence of a signal differentiating disease progression, or change in erosion scores between baseline and 36 months, was found. Further analyses demonstrated that the differential gene expression signature was localized to the patients with the most erosive disease (>10 erosions). Ingenuity Pathway Analysis demonstrated that genes with fold change greater than 1.5 implicated immune pathways such as CTLA signaling in cytotoxic T lymphocytes. These results demonstrate that CLEAR patients with early RA having the most severe erosive disease, as compared to more mild cases (<10 erosions), may be characterized by a set of differentially expressed genes that represent biological pathways with relevance to autoimmune disease." @default.
• W2007111488 created "2016-06-24" @default.
• W2007111488 creator A5000956378 @default.
• W2007111488 creator A5028768811 @default.
• W2007111488 creator A5029597544 @default.
• W2007111488 creator A5031534916 @default.
• W2007111488 creator A5036475457 @default.
• W2007111488 creator A5042725857 @default.
• W2007111488 creator A5043236813 @default.
• W2007111488 creator A5046471721 @default.
• W2007111488 creator A5051069161 @default.
• W2007111488 creator A5069987570 @default.
• W2007111488 creator A5076052964 @default.
• W2007111488 creator A5079145587 @default.
• W2007111488 creator A5082248535 @default.
• W2007111488 creator A5090731148 @default.
• W2007111488 date "2012-01-12" @default.
• W2007111488 modified "2023-09-27" @default.
• W2007111488 title "Gene expression patterns in peripheral blood cells associated with radiographic severity in African Americans with early rheumatoid arthritis" @default.
• W2007111488 cites W1564416982 @default.
• W2007111488 cites W1987036141 @default.
• W2007111488 cites W1987775505 @default.
• W2007111488 cites W2005817811 @default.
• W2007111488 cites W2014081699 @default.
• W2007111488 cites W2015865604 @default.
• W2007111488 cites W2017548224 @default.
• W2007111488 cites W2034411737 @default.
• W2007111488 cites W2100421363 @default.
• W2007111488 cites W2102864522 @default.
• W2007111488 cites W2103089222 @default.
• W2007111488 cites W2110891968 @default.
• W2007111488 cites W2113990193 @default.
• W2007111488 cites W2115783720 @default.
• W2007111488 cites W2120865735 @default.
• W2007111488 cites W2123787596 @default.
• W2007111488 cites W2133465414 @default.
• W2007111488 cites W2141703917 @default.
• W2007111488 cites W2151954973 @default.
• W2007111488 cites W2157134038 @default.
• W2007111488 cites W2157816493 @default.
• W2007111488 cites W2165147469 @default.
• W2007111488 cites W2170864497 @default.
• W2007111488 cites W2170984667 @default.
• W2007111488 cites W2171698193 @default.
• W2007111488 cites W4234141179 @default.
• W2007111488 doi "https://doi.org/10.1007/s00296-011-2355-3" @default.
• W2007111488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3769702" @default.
• W2007111488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22238028" @default.
• W2007111488 hasPublicationYear "2012" @default.
• W2007111488 type Work @default.
• W2007111488 sameAs 2007111488 @default.
• W2007111488 citedByCount "12" @default.
• W2007111488 countsByYear W20071114882013 @default.
• W2007111488 countsByYear W20071114882014 @default.
• W2007111488 countsByYear W20071114882015 @default.
• W2007111488 countsByYear W20071114882016 @default.
• W2007111488 countsByYear W20071114882017 @default.
• W2007111488 countsByYear W20071114882019 @default.
• W2007111488 countsByYear W20071114882020 @default.
• W2007111488 countsByYear W20071114882023 @default.
• W2007111488 crossrefType "journal-article" @default.
• W2007111488 hasAuthorship W2007111488A5000956378 @default.
• W2007111488 hasAuthorship W2007111488A5028768811 @default.
• W2007111488 hasAuthorship W2007111488A5029597544 @default.
• W2007111488 hasAuthorship W2007111488A5031534916 @default.
• W2007111488 hasAuthorship W2007111488A5036475457 @default.
• W2007111488 hasAuthorship W2007111488A5042725857 @default.
• W2007111488 hasAuthorship W2007111488A5043236813 @default.
• W2007111488 hasAuthorship W2007111488A5046471721 @default.
• W2007111488 hasAuthorship W2007111488A5051069161 @default.
• W2007111488 hasAuthorship W2007111488A5069987570 @default.
• W2007111488 hasAuthorship W2007111488A5076052964 @default.
• W2007111488 hasAuthorship W2007111488A5079145587 @default.
• W2007111488 hasAuthorship W2007111488A5082248535 @default.
• W2007111488 hasAuthorship W2007111488A5090731148 @default.
• W2007111488 hasBestOaLocation W20071114882 @default.
• W2007111488 hasConcept C104317684 @default.
• W2007111488 hasConcept C126322002 @default.
• W2007111488 hasConcept C137061746 @default.
• W2007111488 hasConcept C142724271 @default.
• W2007111488 hasConcept C150194340 @default.
• W2007111488 hasConcept C18431079 @default.
• W2007111488 hasConcept C198451711 @default.
• W2007111488 hasConcept C202751555 @default.
• W2007111488 hasConcept C203014093 @default.
• W2007111488 hasConcept C2777575956 @default.
• W2007111488 hasConcept C2779018089 @default.
• W2007111488 hasConcept C2779075594 @default.
• W2007111488 hasConcept C2779134260 @default.
• W2007111488 hasConcept C54355233 @default.
• W2007111488 hasConcept C71924100 @default.
• W2007111488 hasConcept C86803240 @default.
• W2007111488 hasConcept C8891405 @default.
• W2007111488 hasConceptScore W2007111488C104317684 @default.
• W2007111488 hasConceptScore W2007111488C126322002 @default.
• W2007111488 hasConceptScore W2007111488C137061746 @default.
• W2007111488 hasConceptScore W2007111488C142724271 @default.
• W2007111488 hasConceptScore W2007111488C150194340 @default.

• next