FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007113821> ?p ?o ?g. }

• W2007113821 endingPage "452" @default.
• W2007113821 startingPage "451" @default.
• W2007113821 abstract "Dear Editor,We recently encountered a rare case of testicular mixed germ cell tumor (MGCT) in a 32-year-old man. The tumor was composed of a combination of a yolk sac tumor, teratoma and rhabdomyosarcomatous somatic type malignancy.The patient presented with left testicular swelling and pain. Physical examination, ultrasonography and computed tomography revealed a tumor in the left testicle. Alpha feto-protein (AFP) was elevated (720 mIU mL−1; normal reference range: 0–9 mIU mL−1). A simple orchiectomy was performed.Grossly, the tumor was tan and well circumscribed, measuring 7.0 × 6.0 × 4.5 cm3, showing a soft and yellow cut surface, with areas of cartilaginous tissue and only a slim margin of residual testicular tissue. Away from the main mass there was an additional well-circumscribed nodule (12 mm in diameter) (Figure 1A).Figure 1Grossly, the tumor was well circumscribed, showing a soft and yellow cut surface, with areas of cartilaginous tissue and with only a slim margin of residual testicular tissue. Away from the main mass there was an additional well-circumscribed nodule (A). ...Routine formalin-fixed, paraffin-embedded tissue sections were stained with hematoxylin and eosin. An additional immunohistochemical stain for desmin, myoglobin and myogenin (DAKO, Glostrup, Denmark) was performed on a representative section of the tumor.Microscopically, the tumor was composed of a yolk sac tumor (50%) and a mature teratoma (30%) germ cell component associated with a somatic type embryonal rhabdomyosarcoma component (20%). The size of the largest focus of the rhabdomyosarcoma component is 12 mm. The yolk sac tumor showed a microcystic pattern, glandular structures, mesenchymal stroma, and partly micropapillary structures with perivascular Schiller–Duval bodies (Figure 1B). The teratoma was composed of well-differentiated cartilage and cystic formations surrounded with dense connective tissue stroma (Figure 1C). The rhabdomyosarcomatous component from a separate nodule showed sheets of atypical small cells with pleomorphic hyperchromatic nuclei and elongated cells with abundant eosinophilic cytoplasm (Figure 1D and E). The mitotic count was high (7/10 HPF). Immunohistochemically these cells strongly expressed desmin (Figure 1F), myogenin (Figure 1G) and myoglobin (Figure 1H). The adjacent testicular parenchyma contained foci of intratubular germ cell neoplasia of an unclassified type. Necrosis was observed in less than 10% of the tumor. No signs of vascular invasion and no spread to the rete testis, epididymis or beyond the tunica albuginea were found. Follow-up at 6 months after surgery did not show any recurrence or metastasis. The patient did not receive any additional therapy.In the study by Bray et al. 1, the incidence of testicular cancer has shown a consistent increase in the European countries, while at the same time there was a decline in testicular cancer mortality. Advances in the treatment of testicular cancer caused large decreases in mortality in some European countries, despite increases in incidence 1.Testicular MGCTs represent 32%–54% of all germ cell tumors 2, 3. They usually occur at the mean age of 30 years. Clinical presentation includes painless or painful enlargement of the testis. Serum levels of AFP and beta-hCG are often elevated 2.MGCTs consist of more than one histological component that may occur in any combination. Testicular germ cell tumors are omnipotent, can proliferate into homogeneous seminomas and are able to differentiate into any type of tissue, both in the embryo and outside, and form seminomas or nonseminomas (teratomas). The precursor lesion or carcinoma in situ cells show phenotypic similarity to primordial germ cells or gonocytes, which suggests that the cells were stopped at an early stage of differentiation 4.The most common combination is teratoma and embryonal carcinoma 2. A case of rhabdomyosarcoma in a mature teratoma and a case of rhabdomyosarcoma in a mediastinal teratoma have been reported 3, 5. Nongerm cell malignant tumors of somatic type malignancy may arise in primary or metastatic germ cell tumors and are most likely derived from teratomas. They are seen in 3%–6% of patients with metastatic MGCTs, suggesting a poor prognosis 2.MGCT of the testis in combination with the somatic type rhabdomyosarcoma that occurred in our patient is quite uncommon. Recognition of this variant is important because it may mimic a somatic sarcoma if inadequately sampled, and the clinical outcome may differ from the typical testicular MGCT. Therefore, correct histological analysis of testicular MGCTs and their metastases are essential parts of the diagnosis that will guide the correct therapeutic approach and give useful information on the prognosis." @default.
• W2007113821 created "2016-06-24" @default.
• W2007113821 creator A5001584354 @default.
• W2007113821 creator A5060245819 @default.
• W2007113821 creator A5064243493 @default.
• W2007113821 creator A5079765831 @default.
• W2007113821 creator A5090777038 @default.
• W2007113821 date "2010-02-22" @default.
• W2007113821 modified "2023-10-18" @default.
• W2007113821 title "An unusual mixed germ cell tumor of the testis consisting of rhabdomyosarcoma, mature teratoma and yolk sac tumor" @default.
• W2007113821 cites W2013036949 @default.
• W2007113821 cites W2023476942 @default.
• W2007113821 cites W2027917454 @default.
• W2007113821 cites W2142689346 @default.
• W2007113821 cites W2372936169 @default.
• W2007113821 doi "https://doi.org/10.1038/aja.2010.2" @default.
• W2007113821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3739272" @default.
• W2007113821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20173766" @default.
• W2007113821 hasPublicationYear "2010" @default.
• W2007113821 type Work @default.
• W2007113821 sameAs 2007113821 @default.
• W2007113821 citedByCount "4" @default.
• W2007113821 countsByYear W20071138212013 @default.
• W2007113821 countsByYear W20071138212018 @default.
• W2007113821 countsByYear W20071138212021 @default.
• W2007113821 crossrefType "journal-article" @default.
• W2007113821 hasAuthorship W2007113821A5001584354 @default.
• W2007113821 hasAuthorship W2007113821A5060245819 @default.
• W2007113821 hasAuthorship W2007113821A5064243493 @default.
• W2007113821 hasAuthorship W2007113821A5079765831 @default.
• W2007113821 hasAuthorship W2007113821A5090777038 @default.
• W2007113821 hasBestOaLocation W20071138211 @default.
• W2007113821 hasConcept C104317684 @default.
• W2007113821 hasConcept C126322002 @default.
• W2007113821 hasConcept C142724271 @default.
• W2007113821 hasConcept C196843134 @default.
• W2007113821 hasConcept C2776057878 @default.
• W2007113821 hasConcept C2776694085 @default.
• W2007113821 hasConcept C2776938808 @default.
• W2007113821 hasConcept C2777043721 @default.
• W2007113821 hasConcept C2777176876 @default.
• W2007113821 hasConcept C2778256501 @default.
• W2007113821 hasConcept C2779122487 @default.
• W2007113821 hasConcept C2780844630 @default.
• W2007113821 hasConcept C502942594 @default.
• W2007113821 hasConcept C54355233 @default.
• W2007113821 hasConcept C71924100 @default.
• W2007113821 hasConcept C86803240 @default.
• W2007113821 hasConcept C95444343 @default.
• W2007113821 hasConceptScore W2007113821C104317684 @default.
• W2007113821 hasConceptScore W2007113821C126322002 @default.
• W2007113821 hasConceptScore W2007113821C142724271 @default.
• W2007113821 hasConceptScore W2007113821C196843134 @default.
• W2007113821 hasConceptScore W2007113821C2776057878 @default.
• W2007113821 hasConceptScore W2007113821C2776694085 @default.
• W2007113821 hasConceptScore W2007113821C2776938808 @default.
• W2007113821 hasConceptScore W2007113821C2777043721 @default.
• W2007113821 hasConceptScore W2007113821C2777176876 @default.
• W2007113821 hasConceptScore W2007113821C2778256501 @default.
• W2007113821 hasConceptScore W2007113821C2779122487 @default.
• W2007113821 hasConceptScore W2007113821C2780844630 @default.
• W2007113821 hasConceptScore W2007113821C502942594 @default.
• W2007113821 hasConceptScore W2007113821C54355233 @default.
• W2007113821 hasConceptScore W2007113821C71924100 @default.
• W2007113821 hasConceptScore W2007113821C86803240 @default.
• W2007113821 hasConceptScore W2007113821C95444343 @default.
• W2007113821 hasIssue "3" @default.
• W2007113821 hasLocation W20071138211 @default.
• W2007113821 hasLocation W20071138212 @default.
• W2007113821 hasLocation W20071138213 @default.
• W2007113821 hasLocation W20071138214 @default.
• W2007113821 hasOpenAccess W2007113821 @default.
• W2007113821 hasPrimaryLocation W20071138211 @default.
• W2007113821 hasRelatedWork W2006555689 @default.
• W2007113821 hasRelatedWork W2023476942 @default.
• W2007113821 hasRelatedWork W2026506918 @default.
• W2007113821 hasRelatedWork W2047758083 @default.
• W2007113821 hasRelatedWork W2055798832 @default.
• W2007113821 hasRelatedWork W2090250383 @default.
• W2007113821 hasRelatedWork W2416242781 @default.
• W2007113821 hasRelatedWork W2617576984 @default.
• W2007113821 hasRelatedWork W3149248396 @default.
• W2007113821 hasRelatedWork W4284895627 @default.
• W2007113821 hasVolume "12" @default.
• W2007113821 isParatext "false" @default.
• W2007113821 isRetracted "false" @default.
• W2007113821 magId "2007113821" @default.
• W2007113821 workType "article" @default.