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- W2007124472 abstract "Glycosaminoglycans such as heparin, heparan sulphate and dermatan sulphate, are distributed widely in the human body. Several glycosaminoglycans form part of the extracellular matrix and heparan sulphate is expressed on all eukaryotic surfaces. The identification of specific binding to different glycosaminoglycan molecules by bacteria (e.g., Helicobacter pylori, Bordetella pertussis and Chlamydia trachomatis), viruses (e.g., herpes simplex and dengue virus), and protozoa (e.g., Plasmodium and Leishmania), is therefore of great interest. Expression of glycosaminoglycan-binding proteins depends on growth and culture conditions in bacteria, and differs in various phases of parasite development. Glycosaminoglycan-binding microbial proteins may mediate adhesion of microbes to eukaryotic cells, which may be a primary mechanism in mucosal infections, and are also involved in secondary effects such as adhesion to cerebral endothelia in cerebral malaria or to synovial membranes in arthritis caused by Borrelia burgdorferi. It has been suggested that they may enhance intracellular survival in macrophages. Microbial binding of heparin may interfere with heparin-dependent growth factors. Whether or not glycosaminoglycan-binding proteins mediate invasion of epithelial cells is a matter of controversy. Heparin and other glycosaminoglycans may have potential uses as therapeutic agents in microbial infections and could form part of future vaccines against such infections." @default.
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- W2007124472 date "1999-03-01" @default.
- W2007124472 modified "2023-10-03" @default.
- W2007124472 title "Glycosaminoglycan-binding microbial proteins in tissue adhesion and invasion: key events in microbial pathogenicity" @default.
- W2007124472 cites W1615286010 @default.
- W2007124472 cites W1666791883 @default.
- W2007124472 cites W1819210299 @default.
- W2007124472 cites W1839872044 @default.
- W2007124472 cites W1897941512 @default.
- W2007124472 cites W1927596245 @default.
- W2007124472 cites W1929223262 @default.
- W2007124472 cites W1930313341 @default.
- W2007124472 cites W1941554275 @default.
- W2007124472 cites W1963891143 @default.
- W2007124472 cites W1966530484 @default.
- W2007124472 cites W1971976758 @default.
- W2007124472 cites W1977775315 @default.
- W2007124472 cites W1979851989 @default.
- W2007124472 cites W1982330251 @default.
- W2007124472 cites W1985132976 @default.
- W2007124472 cites W1987702283 @default.
- W2007124472 cites W1993096337 @default.
- W2007124472 cites W1994521388 @default.
- W2007124472 cites W1998439953 @default.
- W2007124472 cites W2013933993 @default.
- W2007124472 cites W2023967541 @default.
- W2007124472 cites W2044208804 @default.
- W2007124472 cites W2044229410 @default.
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- W2007124472 cites W2074695999 @default.
- W2007124472 cites W2083024085 @default.
- W2007124472 cites W2083267921 @default.
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- W2007124472 cites W2102320035 @default.
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- W2007124472 doi "https://doi.org/10.1099/00222615-48-3-223" @default.
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