FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007124700> ?p ?o ?g. }

• W2007124700 endingPage "486" @default.
• W2007124700 startingPage "478" @default.
• W2007124700 abstract "Xenopus laevis oocytes are a powerful tool for the characterization of signal transduction pathways leading to the induction of DNA synthesis. Since activation of PLA2, PLC, or PLD has been postulated as a mediator of ras function, we have used the oocyte system to study the putative functional relationship between ras-p21 and these phospholipases. A rapid generation of PA and DAG was observed after ras-p21 microinjection, suggesting the activation of both PLC and PLD enzymes. However, production of DAG was sensitive to inhibition of the PA-hydrolase by propranolol, indicating that PLD is the enzyme responsible for the generation of both PA and DAG. Microinjection of PLD or ras-p21 induced the late production of lysophosphatidylcholine on a p42MAPK-dependent manner, an indication of the activation of a PLA2. Inhibition of this enzyme by quinacrine does not inhibit PLD- or ras-induced GVBD, suggesting that PLA2 activation is not needed for ras or PLD function. Contrary to 3T3 fibroblasts, where ras-p21 is functionally dependent for its mitogenic activity on TPA- and staurosporine-sensitive PKC isoforms, in Xenopus oocytes, induction of GVBD by ras-p21 was independent of PKC, while PLC-induced GVBD was sensitive to PKC inhibition. Thus, our results demonstrate the activation of PLD and PLA2 by ras-p21 proteins, while no effect on PLC was observed." @default.
• W2007124700 created "2016-06-24" @default.
• W2007124700 creator A5013232541 @default.
• W2007124700 creator A5040208664 @default.
• W2007124700 creator A5063985660 @default.
• W2007124700 date "1994-04-01" @default.
• W2007124700 modified "2023-10-11" @default.
• W2007124700 title "ras-p21 Activates phospholipase D and A2, but not phospholipase C or PKC, inXenopus laevis Oocytes" @default.
• W2007124700 cites W10133016 @default.
• W2007124700 cites W1487365829 @default.
• W2007124700 cites W1492921042 @default.
• W2007124700 cites W1523901972 @default.
• W2007124700 cites W1560104562 @default.
• W2007124700 cites W1586837785 @default.
• W2007124700 cites W1593923401 @default.
• W2007124700 cites W1778939557 @default.
• W2007124700 cites W1838271375 @default.
• W2007124700 cites W1838818735 @default.
• W2007124700 cites W1956661481 @default.
• W2007124700 cites W196434780 @default.
• W2007124700 cites W1967008515 @default.
• W2007124700 cites W1969560454 @default.
• W2007124700 cites W1977598234 @default.
• W2007124700 cites W1978798502 @default.
• W2007124700 cites W2005189737 @default.
• W2007124700 cites W2005887351 @default.
• W2007124700 cites W2008333101 @default.
• W2007124700 cites W2043335974 @default.
• W2007124700 cites W2043517583 @default.
• W2007124700 cites W2047760612 @default.
• W2007124700 cites W2048784760 @default.
• W2007124700 cites W2058333572 @default.
• W2007124700 cites W2061628918 @default.
• W2007124700 cites W2062039330 @default.
• W2007124700 cites W2069132844 @default.
• W2007124700 cites W2087437369 @default.
• W2007124700 cites W2095351375 @default.
• W2007124700 cites W2135757784 @default.
• W2007124700 cites W2138917208 @default.
• W2007124700 cites W2146388445 @default.
• W2007124700 cites W2163287185 @default.
• W2007124700 cites W2249893227 @default.
• W2007124700 cites W2320343461 @default.
• W2007124700 cites W4232777855 @default.
• W2007124700 cites W4256011908 @default.
• W2007124700 doi "https://doi.org/10.1002/jcb.240540415" @default.
• W2007124700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8014197" @default.
• W2007124700 hasPublicationYear "1994" @default.
• W2007124700 type Work @default.
• W2007124700 sameAs 2007124700 @default.
• W2007124700 citedByCount "26" @default.
• W2007124700 countsByYear W20071247002018 @default.
• W2007124700 countsByYear W20071247002019 @default.
• W2007124700 countsByYear W20071247002022 @default.
• W2007124700 crossrefType "journal-article" @default.
• W2007124700 hasAuthorship W2007124700A5013232541 @default.
• W2007124700 hasAuthorship W2007124700A5040208664 @default.
• W2007124700 hasAuthorship W2007124700A5063985660 @default.
• W2007124700 hasConcept C104317684 @default.
• W2007124700 hasConcept C125209161 @default.
• W2007124700 hasConcept C153911025 @default.
• W2007124700 hasConcept C185592680 @default.
• W2007124700 hasConcept C195794163 @default.
• W2007124700 hasConcept C202751555 @default.
• W2007124700 hasConcept C2778597717 @default.
• W2007124700 hasConcept C2779084600 @default.
• W2007124700 hasConcept C2779535977 @default.
• W2007124700 hasConcept C55493867 @default.
• W2007124700 hasConcept C6182249 @default.
• W2007124700 hasConcept C62478195 @default.
• W2007124700 hasConcept C62525196 @default.
• W2007124700 hasConcept C64241487 @default.
• W2007124700 hasConcept C86803240 @default.
• W2007124700 hasConcept C95444343 @default.
• W2007124700 hasConceptScore W2007124700C104317684 @default.
• W2007124700 hasConceptScore W2007124700C125209161 @default.
• W2007124700 hasConceptScore W2007124700C153911025 @default.
• W2007124700 hasConceptScore W2007124700C185592680 @default.
• W2007124700 hasConceptScore W2007124700C195794163 @default.
• W2007124700 hasConceptScore W2007124700C202751555 @default.
• W2007124700 hasConceptScore W2007124700C2778597717 @default.
• W2007124700 hasConceptScore W2007124700C2779084600 @default.
• W2007124700 hasConceptScore W2007124700C2779535977 @default.
• W2007124700 hasConceptScore W2007124700C55493867 @default.
• W2007124700 hasConceptScore W2007124700C6182249 @default.
• W2007124700 hasConceptScore W2007124700C62478195 @default.
• W2007124700 hasConceptScore W2007124700C62525196 @default.
• W2007124700 hasConceptScore W2007124700C64241487 @default.
• W2007124700 hasConceptScore W2007124700C86803240 @default.
• W2007124700 hasConceptScore W2007124700C95444343 @default.
• W2007124700 hasIssue "4" @default.
• W2007124700 hasLocation W20071247001 @default.
• W2007124700 hasLocation W20071247002 @default.
• W2007124700 hasOpenAccess W2007124700 @default.
• W2007124700 hasPrimaryLocation W20071247001 @default.
• W2007124700 hasRelatedWork W195305732 @default.
• W2007124700 hasRelatedWork W1990708453 @default.
• W2007124700 hasRelatedWork W1994457450 @default.

• next