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- W2007127898 abstract "JNK-mediated closure of the Drosophila dorsal epidermis during embryogenesis is a well-characterised model for morphogenesis. However, little is known about how JNK signalling modifies particular cellular behaviours such as intracellular transport. Here we demonstrate that the gene encoding the small GTPase Rab30 is a new JNK transcriptional target whose function is required during embryonic and adult morphogenesis including JNK-dependent dorsal closure, embryonic head involution and thorax closure. Using immuno-fluorescence and live imaging, we show that EGFP-Rab30 localises to trans-Golgi in addition to small unidentified vesicles, and moves in a microtubule-dependent, polarised dorso-ventral manner in the leading edge during dorsal closure. We propose that JNK activity upregulates genes involved in intracellular transport in order to provide an increased level of trafficking activity in cells undergoing complex morphogenetic arrangements such as dorsal closure." @default.
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- W2007127898 date "2009-07-01" @default.
- W2007127898 modified "2023-10-16" @default.
- W2007127898 title "JNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30" @default.
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- W2007127898 doi "https://doi.org/10.1016/j.ydbio.2009.05.001" @default.
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