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• W2007131276 abstract "To explore the effect of catalpol on choline acetyl-transferase and M receptor affinity in a PC12 cell model and a rat model induced by beta-amyloid 25–35 (Aβ25–35). In PC12 cells, catalpol (10 μmol/l, 100 μmol/) or saline was retained in the medium and Aβ25–35 (final concentration 20 μmol/l) was added. Choline acetyl-transferase (ChAT) expression was determined by immunocytochemistry, ChAT activity measured by radioenzymatic assay, and M receptor (muscarinic receptor) affinity determined by 3H-QNB binding test. In Wistar rats, Aβ25–35 was injected intracerebroventricularly to establish AD model. After injection of Aβ25–35, the rats were injected catalpol at 5 and 10 mg/kg d−1 intraperitoneally for the next 7 days, and saline for the control rats. ChAT expression, ChAT activity and M receptor affinity were tested. Cells and rats all were divided into four groups: Group A (control), Group B (model), Group C (catalpol low dose), and Group D (catalpol high dose). Compared with control, both PC12 cell and rat AD models showed decreased expression and activity of ChAT (p < 0.01), but M receptor affinity remained the same (p > 0.05). Compared with model group, treatment of catalpol increased expression and activity of ChAT of PC12 cell and rat AD model induced by Aβ25–35, p < 0.05 or p < 0.01 respectively. But there was no difference of M receptor affinity among the four groups (p > 0.05). M receptor affinity remained the same as concentration of catalpol increased gradually in atropine competition experiments (p > 0.05). Catalpol could regulate the cholinergic nerve system function from its effect on ChAT and may have beneficial effect for treatment of AD, but had no effect on M receptor affinity." @default.
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• W2007131276 date "2015-02-01" @default.
• W2007131276 modified "2023-10-08" @default.
• W2007131276 title "Catalpol regulates cholinergic nerve system function through effect on choline acetyl-transferase not M receptor affinity" @default.
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• W2007131276 doi "https://doi.org/10.1016/j.biopha.2014.12.014" @default.
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