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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007131458> ?p ?o ?g. }

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• W2007131458 abstract "Previous work has established that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is stabilized in an ATM-dependent manner in response to DNA damage and acts as a cofactor for p53-mediated transcription. Here, we show that in response to DNA damage caused by ionizing radiation, hnRNP K is phosphorylated in an ATM-dependent manner. Furthermore, our data indicate that ATM-dependent hnRNP K phosphorylation is required for its stabilization and its function as a p53 transcriptional cofactor in response to DNA damage. These findings thereby establish hnRNP K as an ATM target and help define how ATM orchestrates p53-dependent transcriptional responses in response to genotoxic stress." @default.
• W2007131458 created "2016-06-24" @default.
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• W2007131458 date "2013-02-15" @default.
• W2007131458 modified "2023-09-25" @default.
• W2007131458 title "ATM-dependent phosphorylation of heterogeneous nuclear ribonucleoprotein K promotes p53 transcriptional activation in response to DNA damage" @default.
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• W2007131458 doi "https://doi.org/10.4161/cc.23592" @default.
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