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- W2007131570 abstract "HBV has two enhancer (En) regions each of which promotes its own transcription. En II regulates production of pregenomic RNA, a key product of HBV replication, more strongly than En I. Although IFN-α has been found to suppress En I activity, its effect on En II activity has not been examined. Here we used luciferase assay to demonstrate that IFN-α suppresses En II activity. Analysis with several deletion/mutation constructs identified two major segments, nt 1703–1727 and nt 1746–1770, within the En II sequence as being responsible for the suppressive effects of IFN-α. Pre-treatment with protein kinase C (PKC) inhibitors blocked this effect regardless of the expression levels of phospho-STAT1 and Mx upon IFN-α stimulation. These results indicate that IFN-α suppresses En II activity via the PKC pathway, which may be an alternative suppressive pathway for HBV replication. (136 words)." @default.
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- W2007131570 date "2012-10-01" @default.
- W2007131570 modified "2023-10-16" @default.
- W2007131570 title "Interferon-α suppresses hepatitis B virus enhancer II activity via the protein kinase C pathway" @default.
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- W2007131570 doi "https://doi.org/10.1016/j.virol.2012.07.002" @default.
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