FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007134315> ?p ?o ?g. }

• W2007134315 endingPage "346" @default.
• W2007134315 startingPage "339" @default.
• W2007134315 abstract "A novel method, known as computed helical anti-membrane protein (CHAMP), for the design of peptides that bind with high affinity and selectivity to transmembrane helices was recently described and illustrated using peptides that bind alphaIIb- and alphav-integrin subunits, which induce selective activation of integrins alphaIIbbeta3 and alphavbeta3, respectively.In the present study, we have investigated the ability of an alphaIIb-CHAMPS peptide (termed integrin-activatory-peptide or IAP) to stimulate protein tyrosine phosphorylation and aggregation in human and mouse platelets.The ability of IAP to stimulate platelet aggregation and dense granule secretion was measured in washed preparations of human and mouse platelets. Samples were taken for measurement of tyrosine phosphorylation.IAP stimulates robust tyrosine phosphorylation of the tyrosine kinase Syk and the FcR gamma-chain, but only weak phosphorylation of PLCgamma2. Aggregation to low but not high concentrations of IAP is reduced in the presence of the Src kinase inhibitor, PP1, or by inhibitors of the two feedback agonists, ADP and thromboxane A(2) (TxA(2)) suggesting that activation is reinforced by Src kinase-driven release of ADP and TxA(2). Unexpectedly, aggregation by IAP is only partially inhibited in human and mouse platelets deficient in integrin alphaIIbbeta3. Further, IAP induces partial aggregation of formaldehyde-fixed platelets.The present study demonstrates that the alphaIIb-CHAMPS peptide induces platelet activation through integrin alphaIIbbeta3-dependent and independent pathways with the former mediating tyrosine phosphorylation of FcR gamma-chain and Syk. The use of the alphaIIb-CHAMPS peptide to study integrin alphaIIbbeta3 function is compromised by non-integrin-mediated effects." @default.
• W2007134315 created "2016-06-24" @default.
• W2007134315 creator A5000741529 @default.
• W2007134315 creator A5057799772 @default.
• W2007134315 creator A5068584257 @default.
• W2007134315 date "2009-02-01" @default.
• W2007134315 modified "2023-09-30" @default.
• W2007134315 title "Molecular basis of platelet activation by an αIIbβ3‐CHAMPS peptide" @default.
• W2007134315 cites W1526532569 @default.
• W2007134315 cites W1549514523 @default.
• W2007134315 cites W1964681919 @default.
• W2007134315 cites W1968286272 @default.
• W2007134315 cites W1982536372 @default.
• W2007134315 cites W1994860164 @default.
• W2007134315 cites W1995553619 @default.
• W2007134315 cites W1998539678 @default.
• W2007134315 cites W2017755995 @default.
• W2007134315 cites W2040379229 @default.
• W2007134315 cites W2044882848 @default.
• W2007134315 cites W2046186930 @default.
• W2007134315 cites W2050749891 @default.
• W2007134315 cites W2059701371 @default.
• W2007134315 cites W2065921660 @default.
• W2007134315 cites W2077277541 @default.
• W2007134315 cites W2081065182 @default.
• W2007134315 cites W2100577875 @default.
• W2007134315 cites W2111803487 @default.
• W2007134315 cites W2138828504 @default.
• W2007134315 cites W2157095212 @default.
• W2007134315 cites W2165078795 @default.
• W2007134315 cites W2396723835 @default.
• W2007134315 doi "https://doi.org/10.1111/j.1538-7836.2008.03228.x" @default.
• W2007134315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19036072" @default.
• W2007134315 hasPublicationYear "2009" @default.
• W2007134315 type Work @default.
• W2007134315 sameAs 2007134315 @default.
• W2007134315 citedByCount "4" @default.
• W2007134315 countsByYear W20071343152015 @default.
• W2007134315 countsByYear W20071343152016 @default.
• W2007134315 countsByYear W20071343152019 @default.
• W2007134315 countsByYear W20071343152022 @default.
• W2007134315 crossrefType "journal-article" @default.
• W2007134315 hasAuthorship W2007134315A5000741529 @default.
• W2007134315 hasAuthorship W2007134315A5057799772 @default.
• W2007134315 hasAuthorship W2007134315A5068584257 @default.
• W2007134315 hasBestOaLocation W20071343151 @default.
• W2007134315 hasConcept C108636557 @default.
• W2007134315 hasConcept C11960822 @default.
• W2007134315 hasConcept C170493617 @default.
• W2007134315 hasConcept C185592680 @default.
• W2007134315 hasConcept C195687474 @default.
• W2007134315 hasConcept C203014093 @default.
• W2007134315 hasConcept C2776165026 @default.
• W2007134315 hasConcept C2777553839 @default.
• W2007134315 hasConcept C2779281246 @default.
• W2007134315 hasConcept C2910542480 @default.
• W2007134315 hasConcept C3018697912 @default.
• W2007134315 hasConcept C35174551 @default.
• W2007134315 hasConcept C42362537 @default.
• W2007134315 hasConcept C55493867 @default.
• W2007134315 hasConcept C62478195 @default.
• W2007134315 hasConcept C86803240 @default.
• W2007134315 hasConcept C89560881 @default.
• W2007134315 hasConcept C95444343 @default.
• W2007134315 hasConceptScore W2007134315C108636557 @default.
• W2007134315 hasConceptScore W2007134315C11960822 @default.
• W2007134315 hasConceptScore W2007134315C170493617 @default.
• W2007134315 hasConceptScore W2007134315C185592680 @default.
• W2007134315 hasConceptScore W2007134315C195687474 @default.
• W2007134315 hasConceptScore W2007134315C203014093 @default.
• W2007134315 hasConceptScore W2007134315C2776165026 @default.
• W2007134315 hasConceptScore W2007134315C2777553839 @default.
• W2007134315 hasConceptScore W2007134315C2779281246 @default.
• W2007134315 hasConceptScore W2007134315C2910542480 @default.
• W2007134315 hasConceptScore W2007134315C3018697912 @default.
• W2007134315 hasConceptScore W2007134315C35174551 @default.
• W2007134315 hasConceptScore W2007134315C42362537 @default.
• W2007134315 hasConceptScore W2007134315C55493867 @default.
• W2007134315 hasConceptScore W2007134315C62478195 @default.
• W2007134315 hasConceptScore W2007134315C86803240 @default.
• W2007134315 hasConceptScore W2007134315C89560881 @default.
• W2007134315 hasConceptScore W2007134315C95444343 @default.
• W2007134315 hasIssue "2" @default.
• W2007134315 hasLocation W20071343151 @default.
• W2007134315 hasLocation W20071343152 @default.
• W2007134315 hasOpenAccess W2007134315 @default.
• W2007134315 hasPrimaryLocation W20071343151 @default.
• W2007134315 hasRelatedWork W1976198549 @default.
• W2007134315 hasRelatedWork W2007134315 @default.
• W2007134315 hasRelatedWork W2078968133 @default.
• W2007134315 hasRelatedWork W2081016687 @default.
• W2007134315 hasRelatedWork W2096032969 @default.
• W2007134315 hasRelatedWork W2259376458 @default.
• W2007134315 hasRelatedWork W2302141181 @default.
• W2007134315 hasRelatedWork W2400314201 @default.
• W2007134315 hasRelatedWork W2903222160 @default.
• W2007134315 hasRelatedWork W4247927249 @default.
• W2007134315 hasVolume "7" @default.

• next