Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007135034> ?p ?o ?g. }
- W2007135034 endingPage "201" @default.
- W2007135034 startingPage "194" @default.
- W2007135034 abstract "The epidermis is a continuously renewing tissue maintained by undifferentiated stem cells. For decades it has been assumed that epidermal stem cells (ESCs) were held in the G0 phase of the cell cycle and that they only entered the cell cycle when needed. Previously, we showed that ESCs retained nuclear label for long periods, indicating that these cells did not proceed through the cell cycle at the same rate as the other proliferative basal cells. However, their exact cell-cycle profile has not been determined because a pure population of ESCs has not been available. In this study, we sorted stem and transient amplifying (TA) cells from murine neonatal back skin, and adult ear, footpad, and back skin, using our recently developed method. We found that neonatal back skin had two times the number of ESCs as the adult tissues. Despite the age and anatomical difference, these ESC populations exhibited similar cell cycle profiles with approximately 96% in G0/G1 and 4% in S-G2/M. The cell cycle profiles of the TA cells from neonatal back skin and adult footpad also showed a profile similar to each other (85% in G1 and 15% in S-G2/M). Examination of genes on a cell cycle chip showed that proliferation associated genes and only p57 were upregulated in the TA cell and ESC population, respectively. We found BrdU positive and cyclin B1 positive cells in all groups, confirming that both ESCs and TA cells were cycling. These data demonstrate that there are more TA cells dividing than ESCs, that the cell cycle profile of adult TA cells is related to the proliferative state of the tissue in which they reside, and that ESC proceed through the cell cycle. © 2003 Wiley-Liss, Inc." @default.
- W2007135034 created "2016-06-24" @default.
- W2007135034 creator A5015766245 @default.
- W2007135034 creator A5022096927 @default.
- W2007135034 creator A5046582804 @default.
- W2007135034 creator A5060239081 @default.
- W2007135034 date "2003-03-18" @default.
- W2007135034 modified "2023-10-11" @default.
- W2007135034 title "Mouse epidermal stem cells proceed through the cell cycle" @default.
- W2007135034 cites W1544512904 @default.
- W2007135034 cites W1600103888 @default.
- W2007135034 cites W1894632965 @default.
- W2007135034 cites W1968506175 @default.
- W2007135034 cites W1973869185 @default.
- W2007135034 cites W1979129905 @default.
- W2007135034 cites W1980332250 @default.
- W2007135034 cites W1981048117 @default.
- W2007135034 cites W1989588484 @default.
- W2007135034 cites W1994441429 @default.
- W2007135034 cites W2006531965 @default.
- W2007135034 cites W2019459577 @default.
- W2007135034 cites W2026501903 @default.
- W2007135034 cites W2027384096 @default.
- W2007135034 cites W2027944189 @default.
- W2007135034 cites W2029675195 @default.
- W2007135034 cites W2034425725 @default.
- W2007135034 cites W2037749974 @default.
- W2007135034 cites W2037951426 @default.
- W2007135034 cites W2042188178 @default.
- W2007135034 cites W2049043712 @default.
- W2007135034 cites W2051665279 @default.
- W2007135034 cites W2067024175 @default.
- W2007135034 cites W2067655540 @default.
- W2007135034 cites W2068314329 @default.
- W2007135034 cites W2072740463 @default.
- W2007135034 cites W2073337488 @default.
- W2007135034 cites W2077107241 @default.
- W2007135034 cites W2078035943 @default.
- W2007135034 cites W2085021251 @default.
- W2007135034 cites W2094523038 @default.
- W2007135034 cites W2099061565 @default.
- W2007135034 cites W2112364863 @default.
- W2007135034 cites W2112549882 @default.
- W2007135034 cites W2119704135 @default.
- W2007135034 cites W2121619780 @default.
- W2007135034 cites W2128078747 @default.
- W2007135034 cites W2135202770 @default.
- W2007135034 cites W2137956382 @default.
- W2007135034 cites W2148459495 @default.
- W2007135034 cites W2152059851 @default.
- W2007135034 cites W2188089527 @default.
- W2007135034 doi "https://doi.org/10.1002/jcp.10311" @default.
- W2007135034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12652646" @default.
- W2007135034 hasPublicationYear "2003" @default.
- W2007135034 type Work @default.
- W2007135034 sameAs 2007135034 @default.
- W2007135034 citedByCount "35" @default.
- W2007135034 countsByYear W20071350342012 @default.
- W2007135034 countsByYear W20071350342013 @default.
- W2007135034 countsByYear W20071350342014 @default.
- W2007135034 countsByYear W20071350342015 @default.
- W2007135034 countsByYear W20071350342016 @default.
- W2007135034 countsByYear W20071350342017 @default.
- W2007135034 countsByYear W20071350342019 @default.
- W2007135034 countsByYear W20071350342021 @default.
- W2007135034 crossrefType "journal-article" @default.
- W2007135034 hasAuthorship W2007135034A5015766245 @default.
- W2007135034 hasAuthorship W2007135034A5022096927 @default.
- W2007135034 hasAuthorship W2007135034A5046582804 @default.
- W2007135034 hasAuthorship W2007135034A5060239081 @default.
- W2007135034 hasConcept C105702510 @default.
- W2007135034 hasConcept C120504264 @default.
- W2007135034 hasConcept C1491633281 @default.
- W2007135034 hasConcept C153911025 @default.
- W2007135034 hasConcept C16685009 @default.
- W2007135034 hasConcept C203014093 @default.
- W2007135034 hasConcept C2776458125 @default.
- W2007135034 hasConcept C2778437423 @default.
- W2007135034 hasConcept C28328180 @default.
- W2007135034 hasConcept C2908647359 @default.
- W2007135034 hasConcept C29537977 @default.
- W2007135034 hasConcept C54355233 @default.
- W2007135034 hasConcept C62112901 @default.
- W2007135034 hasConcept C71924100 @default.
- W2007135034 hasConcept C86803240 @default.
- W2007135034 hasConcept C95444343 @default.
- W2007135034 hasConcept C99454951 @default.
- W2007135034 hasConceptScore W2007135034C105702510 @default.
- W2007135034 hasConceptScore W2007135034C120504264 @default.
- W2007135034 hasConceptScore W2007135034C1491633281 @default.
- W2007135034 hasConceptScore W2007135034C153911025 @default.
- W2007135034 hasConceptScore W2007135034C16685009 @default.
- W2007135034 hasConceptScore W2007135034C203014093 @default.
- W2007135034 hasConceptScore W2007135034C2776458125 @default.
- W2007135034 hasConceptScore W2007135034C2778437423 @default.
- W2007135034 hasConceptScore W2007135034C28328180 @default.
- W2007135034 hasConceptScore W2007135034C2908647359 @default.
- W2007135034 hasConceptScore W2007135034C29537977 @default.