FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007136285> ?p ?o ?g. }

• W2007136285 endingPage "e80744" @default.
• W2007136285 startingPage "e80744" @default.
• W2007136285 abstract "Sepsis caused by Gram-negative bacterial infection is characterized by extensive inflammatory cytokine production, which leads to multiple organ failure and a high lethality rate. Therefore, compounds that are able to alleviate profound inflammatory responses may have therapeutic potential in relation to sepsis. Quercetin, one of the flavonoids found widely in the human diet, has been reported to have many health benefits, but the mechanisms underlying its biological effects remain obscure. In the present study, our aim was to investigate the molecular mechanisms by which quercetin inhibits lipopolysaccharide (LPS)-induced pro-inflammatory cytokine production and to evaluate the capacity of quercetin to attenuate the mortality rate in a mice model of lethal sepsis. Our results show that quercetin significantly attenuates LPS-induced production of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in RAW264.7 macrophages. The LPS-stimulated phosphorylations of the inhibitors of κB kinase (IKKs), Akt, and c-Jun N-terminal kinase (JNK) are also inhibited by quercetin. Quercetin causes a significant reduction in the phosphorylation and degradation of inhibitor of κBα (IκBα) and in the nuclear level of nuclear factor-κB (NF-κB), the latter being associated with decreased NF-κB binding activity. Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-α and IL-1β in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-α and IL-1β levels. These findings provide clues that quercetin may be a promising agent for the prevention of systemic inflammatory diseases such as sepsis." @default.
• W2007136285 created "2016-06-24" @default.
• W2007136285 creator A5009127365 @default.
• W2007136285 creator A5015332170 @default.
• W2007136285 creator A5023728196 @default.
• W2007136285 creator A5038967843 @default.
• W2007136285 creator A5073237795 @default.
• W2007136285 date "2013-11-19" @default.
• W2007136285 modified "2023-09-30" @default.
• W2007136285 title "The Therapeutic Potential and Mechanisms of Action of Quercetin in Relation to Lipopolysaccharide-Induced Sepsis In Vitro and In Vivo" @default.
• W2007136285 cites W1522420128 @default.
• W2007136285 cites W1534551308 @default.
• W2007136285 cites W1550722396 @default.
• W2007136285 cites W1839867987 @default.
• W2007136285 cites W1966700699 @default.
• W2007136285 cites W1968316822 @default.
• W2007136285 cites W1990817996 @default.
• W2007136285 cites W2003892126 @default.
• W2007136285 cites W2005233032 @default.
• W2007136285 cites W2006444511 @default.
• W2007136285 cites W2010817360 @default.
• W2007136285 cites W2015996393 @default.
• W2007136285 cites W2017877447 @default.
• W2007136285 cites W2024836200 @default.
• W2007136285 cites W2035622300 @default.
• W2007136285 cites W2039839636 @default.
• W2007136285 cites W2059147411 @default.
• W2007136285 cites W2062835892 @default.
• W2007136285 cites W2063131576 @default.
• W2007136285 cites W2064647661 @default.
• W2007136285 cites W2075610879 @default.
• W2007136285 cites W2076243684 @default.
• W2007136285 cites W2079481922 @default.
• W2007136285 cites W2087092025 @default.
• W2007136285 cites W2087861588 @default.
• W2007136285 cites W2096931514 @default.
• W2007136285 cites W2106625687 @default.
• W2007136285 cites W2107495112 @default.
• W2007136285 cites W2120532705 @default.
• W2007136285 cites W2154895253 @default.
• W2007136285 cites W4243836839 @default.
• W2007136285 doi "https://doi.org/10.1371/journal.pone.0080744" @default.
• W2007136285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3834323" @default.
• W2007136285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24260470" @default.
• W2007136285 hasPublicationYear "2013" @default.
• W2007136285 type Work @default.
• W2007136285 sameAs 2007136285 @default.
• W2007136285 citedByCount "55" @default.
• W2007136285 countsByYear W20071362852014 @default.
• W2007136285 countsByYear W20071362852015 @default.
• W2007136285 countsByYear W20071362852016 @default.
• W2007136285 countsByYear W20071362852017 @default.
• W2007136285 countsByYear W20071362852018 @default.
• W2007136285 countsByYear W20071362852019 @default.
• W2007136285 countsByYear W20071362852020 @default.
• W2007136285 countsByYear W20071362852021 @default.
• W2007136285 countsByYear W20071362852022 @default.
• W2007136285 countsByYear W20071362852023 @default.
• W2007136285 crossrefType "journal-article" @default.
• W2007136285 hasAuthorship W2007136285A5009127365 @default.
• W2007136285 hasAuthorship W2007136285A5015332170 @default.
• W2007136285 hasAuthorship W2007136285A5023728196 @default.
• W2007136285 hasAuthorship W2007136285A5038967843 @default.
• W2007136285 hasAuthorship W2007136285A5073237795 @default.
• W2007136285 hasBestOaLocation W20071362851 @default.
• W2007136285 hasConcept C150903083 @default.
• W2007136285 hasConcept C164027704 @default.
• W2007136285 hasConcept C17991360 @default.
• W2007136285 hasConcept C202751555 @default.
• W2007136285 hasConcept C203014093 @default.
• W2007136285 hasConcept C207001950 @default.
• W2007136285 hasConcept C2776914184 @default.
• W2007136285 hasConcept C2777730290 @default.
• W2007136285 hasConcept C2778004101 @default.
• W2007136285 hasConcept C2778384902 @default.
• W2007136285 hasConcept C2778690821 @default.
• W2007136285 hasConcept C2778754761 @default.
• W2007136285 hasConcept C2781263971 @default.
• W2007136285 hasConcept C55493867 @default.
• W2007136285 hasConcept C71924100 @default.
• W2007136285 hasConcept C86803240 @default.
• W2007136285 hasConcept C98274493 @default.
• W2007136285 hasConceptScore W2007136285C150903083 @default.
• W2007136285 hasConceptScore W2007136285C164027704 @default.
• W2007136285 hasConceptScore W2007136285C17991360 @default.
• W2007136285 hasConceptScore W2007136285C202751555 @default.
• W2007136285 hasConceptScore W2007136285C203014093 @default.
• W2007136285 hasConceptScore W2007136285C207001950 @default.
• W2007136285 hasConceptScore W2007136285C2776914184 @default.
• W2007136285 hasConceptScore W2007136285C2777730290 @default.
• W2007136285 hasConceptScore W2007136285C2778004101 @default.
• W2007136285 hasConceptScore W2007136285C2778384902 @default.
• W2007136285 hasConceptScore W2007136285C2778690821 @default.
• W2007136285 hasConceptScore W2007136285C2778754761 @default.
• W2007136285 hasConceptScore W2007136285C2781263971 @default.
• W2007136285 hasConceptScore W2007136285C55493867 @default.
• W2007136285 hasConceptScore W2007136285C71924100 @default.
• W2007136285 hasConceptScore W2007136285C86803240 @default.

• next