Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007137189> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2007137189 abstract "Cationic lipid microbubbles have been shown to load DNA and improve transfection by ultrasound. Protein based microbubbles, which typically have higher transfection ability than lipid-based, have also been made to load DNA but have not been fully trialled in vivo. Glucosamine (GlcA) is a positively charged sugar which could potentially produce a DNA-loading albumin microbubble. Microbubbles were made with 2% (w/v) albumin, octafluoropropane and 55% (w/v) dextrose or 40% (w/v) dextrose and 15% (w/v) GlcA, yielding two bubble types. These were acoustically characterised and their DNA-loading ability was examined. Preliminary in vivo work investigated their effectiveness at transfecting CD1 mice hearts with a luciferase plasmid (pGL4.13) using ultrasound. The two formulations produced microbubbles of similar concentration and size distribution. Bulk acoustic behaviour was also similar, with GlcA microbubbles displaying greater attenuation behaviour. GlcA microbubbles were found to be capable of loading a significantly more plasmid DNA compared to the control bubble; however no difference in transfection ability was noted. DNA-loading albumin microbubbles can be simply made by the addition of GlcA and the produced microbubbles are well-tolerated by mice with no adverse events observed. On-going work will determine the effect of microbubble DNA-loading on ultrasound and microbubble mediated gene transfection (UMGT)." @default.
- W2007137189 created "2016-06-24" @default.
- W2007137189 creator A5034594703 @default.
- W2007137189 creator A5042718579 @default.
- W2007137189 creator A5077943933 @default.
- W2007137189 date "2012-10-01" @default.
- W2007137189 modified "2023-09-26" @default.
- W2007137189 title "The effect of glucosamine on the acoustic and binding properties of albumin-based microbubbles (work in progress)" @default.
- W2007137189 cites W1579604458 @default.
- W2007137189 cites W1599588446 @default.
- W2007137189 cites W19025065 @default.
- W2007137189 cites W1964696510 @default.
- W2007137189 cites W1992433058 @default.
- W2007137189 cites W1992867281 @default.
- W2007137189 cites W2003957602 @default.
- W2007137189 cites W2008977727 @default.
- W2007137189 cites W2010655741 @default.
- W2007137189 cites W2011552504 @default.
- W2007137189 cites W2012307975 @default.
- W2007137189 cites W2014770379 @default.
- W2007137189 cites W2023222258 @default.
- W2007137189 cites W2026999982 @default.
- W2007137189 cites W2032488041 @default.
- W2007137189 cites W2032807728 @default.
- W2007137189 cites W2038570459 @default.
- W2007137189 cites W2043861960 @default.
- W2007137189 cites W2054109232 @default.
- W2007137189 cites W2077120718 @default.
- W2007137189 cites W2078103116 @default.
- W2007137189 cites W2090383227 @default.
- W2007137189 cites W2104672374 @default.
- W2007137189 cites W2130435709 @default.
- W2007137189 cites W2146864931 @default.
- W2007137189 cites W2153125698 @default.
- W2007137189 cites W2154177113 @default.
- W2007137189 cites W2155990691 @default.
- W2007137189 cites W2323613689 @default.
- W2007137189 doi "https://doi.org/10.1109/ultsym.2012.0573" @default.
- W2007137189 hasPublicationYear "2012" @default.
- W2007137189 type Work @default.
- W2007137189 sameAs 2007137189 @default.
- W2007137189 citedByCount "0" @default.
- W2007137189 crossrefType "proceedings-article" @default.
- W2007137189 hasAuthorship W2007137189A5034594703 @default.
- W2007137189 hasAuthorship W2007137189A5042718579 @default.
- W2007137189 hasAuthorship W2007137189A5077943933 @default.
- W2007137189 hasConcept C104317684 @default.
- W2007137189 hasConcept C12554922 @default.
- W2007137189 hasConcept C126838900 @default.
- W2007137189 hasConcept C136229726 @default.
- W2007137189 hasConcept C143753070 @default.
- W2007137189 hasConcept C150903083 @default.
- W2007137189 hasConcept C185592680 @default.
- W2007137189 hasConcept C192562407 @default.
- W2007137189 hasConcept C207001950 @default.
- W2007137189 hasConcept C2776125364 @default.
- W2007137189 hasConcept C54009773 @default.
- W2007137189 hasConcept C552990157 @default.
- W2007137189 hasConcept C55493867 @default.
- W2007137189 hasConcept C64012434 @default.
- W2007137189 hasConcept C71924100 @default.
- W2007137189 hasConcept C86803240 @default.
- W2007137189 hasConceptScore W2007137189C104317684 @default.
- W2007137189 hasConceptScore W2007137189C12554922 @default.
- W2007137189 hasConceptScore W2007137189C126838900 @default.
- W2007137189 hasConceptScore W2007137189C136229726 @default.
- W2007137189 hasConceptScore W2007137189C143753070 @default.
- W2007137189 hasConceptScore W2007137189C150903083 @default.
- W2007137189 hasConceptScore W2007137189C185592680 @default.
- W2007137189 hasConceptScore W2007137189C192562407 @default.
- W2007137189 hasConceptScore W2007137189C207001950 @default.
- W2007137189 hasConceptScore W2007137189C2776125364 @default.
- W2007137189 hasConceptScore W2007137189C54009773 @default.
- W2007137189 hasConceptScore W2007137189C552990157 @default.
- W2007137189 hasConceptScore W2007137189C55493867 @default.
- W2007137189 hasConceptScore W2007137189C64012434 @default.
- W2007137189 hasConceptScore W2007137189C71924100 @default.
- W2007137189 hasConceptScore W2007137189C86803240 @default.
- W2007137189 hasLocation W20071371891 @default.
- W2007137189 hasOpenAccess W2007137189 @default.
- W2007137189 hasPrimaryLocation W20071371891 @default.
- W2007137189 hasRelatedWork W1992433058 @default.
- W2007137189 hasRelatedWork W2063121689 @default.
- W2007137189 hasRelatedWork W2064118832 @default.
- W2007137189 hasRelatedWork W2146341506 @default.
- W2007137189 hasRelatedWork W2265383182 @default.
- W2007137189 hasRelatedWork W2369198308 @default.
- W2007137189 hasRelatedWork W2421589566 @default.
- W2007137189 hasRelatedWork W3169321977 @default.
- W2007137189 hasRelatedWork W4248800110 @default.
- W2007137189 hasRelatedWork W4308099571 @default.
- W2007137189 isParatext "false" @default.
- W2007137189 isRetracted "false" @default.
- W2007137189 magId "2007137189" @default.
- W2007137189 workType "article" @default.