FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007137792> ?p ?o ?g. }

• W2007137792 endingPage "S190" @default.
• W2007137792 startingPage "S190" @default.
• W2007137792 abstract "OBJECTIVE: Missing oocyte activation is the most frequent cause of fertilization failure after ICSI. Oocyte activation is characterized by intracellular calcium oscillations, caused by a recently described phospholipase, PLC-zeta, present in the sperm. Different methods have been proposed to overcome oocyte activation failure in ICSI cycles, including chemical artificial oocyte activation (AOA). There are few studies focused on AOA when sperm from different origins are used. We evaluated the effect of AOA, induced with the calcium ionophore A23187, on ICSI cycles using ejaculated, epididymal, or testicular sperm. DESIGN: Case-control study. MATERIALS AND METHODS: The study included 314 couples undergoing ICSI cycles. The cycles were divided into three experimental groups according to sperm origin: EJACULATED (n=92), EPIDIDYMAL (n=82), and the TESTICULAR (n=140). For each experimental group, cycles in which AOA was applied (subgroup AOA) were matched with cycles in which AOA was not applied (subgroup control-CT). The ICSI outcomes Fertilization; high quality embryos; implantation, rate and miscarriage rates were compared between the AOA and CT subgroups. In order to exclude ovarian factor infertility, the cycles of woman less than 36 years of age were evaluated separately. RESULTS: No significant difference was observed between subgroups for the three sperm origin groups in all evaluated parameters. In cycles in which the female's age was less than 36 years old, no difference was observed in the fertilization, pregnancy or miscarriage rate between subgroups from any spermatozoa origin group. However, AOA was able to increase the high-quality embryos (74.5% vs. 53.0% P = 0.011) and implantation rates (19,3% vs. 10,5% P = 0,0025) when using ejaculated spermatozoa, and AOA also increased the high quality embryos rate (64.4% vs. 50.3%, P = 0,006) when using epididymal spermatozoa. CONCLUSIONS: This is the first large study comparing the effect of AOA on ICSI cycles using sperm from different origin. The reason why, the oocytes injected with ejaculated and epididymal sperm were able to positively respond to AOA while those injected with testicular sperm could not, may be explained by a relation between sperm maturity and the function of oocyte activation. One such hypothesis would be that PLC-zeta is at a different concentration or is inactivated in immature sperm. In addition, AOA improved ICSI outcomes, only in oocytes derived from younger women, which suggests that the oocyte also plays a role in oocyte activation." @default.
• W2007137792 created "2016-06-24" @default.
• W2007137792 creator A5012415649 @default.
• W2007137792 creator A5030261811 @default.
• W2007137792 creator A5055938308 @default.
• W2007137792 creator A5071928367 @default.
• W2007137792 creator A5091167075 @default.
• W2007137792 date "2008-09-01" @default.
• W2007137792 modified "2023-09-28" @default.
• W2007137792 title "Artificial oocyte activation with calcium ionophore A23187 in ICSI cycles with sperm from different origins" @default.
• W2007137792 doi "https://doi.org/10.1016/j.fertnstert.2008.07.674" @default.
• W2007137792 hasPublicationYear "2008" @default.
• W2007137792 type Work @default.
• W2007137792 sameAs 2007137792 @default.
• W2007137792 citedByCount "0" @default.
• W2007137792 crossrefType "journal-article" @default.
• W2007137792 hasAuthorship W2007137792A5012415649 @default.
• W2007137792 hasAuthorship W2007137792A5030261811 @default.
• W2007137792 hasAuthorship W2007137792A5055938308 @default.
• W2007137792 hasAuthorship W2007137792A5071928367 @default.
• W2007137792 hasAuthorship W2007137792A5091167075 @default.
• W2007137792 hasBestOaLocation W20071377921 @default.
• W2007137792 hasConcept C105702510 @default.
• W2007137792 hasConcept C16685009 @default.
• W2007137792 hasConcept C179265757 @default.
• W2007137792 hasConcept C196843134 @default.
• W2007137792 hasConcept C2776690073 @default.
• W2007137792 hasConcept C2781087480 @default.
• W2007137792 hasConcept C54355233 @default.
• W2007137792 hasConcept C71924100 @default.
• W2007137792 hasConcept C86803240 @default.
• W2007137792 hasConcept C88972607 @default.
• W2007137792 hasConceptScore W2007137792C105702510 @default.
• W2007137792 hasConceptScore W2007137792C16685009 @default.
• W2007137792 hasConceptScore W2007137792C179265757 @default.
• W2007137792 hasConceptScore W2007137792C196843134 @default.
• W2007137792 hasConceptScore W2007137792C2776690073 @default.
• W2007137792 hasConceptScore W2007137792C2781087480 @default.
• W2007137792 hasConceptScore W2007137792C54355233 @default.
• W2007137792 hasConceptScore W2007137792C71924100 @default.
• W2007137792 hasConceptScore W2007137792C86803240 @default.
• W2007137792 hasConceptScore W2007137792C88972607 @default.
• W2007137792 hasLocation W20071377921 @default.
• W2007137792 hasOpenAccess W2007137792 @default.
• W2007137792 hasPrimaryLocation W20071377921 @default.
• W2007137792 hasRelatedWork W1972453963 @default.
• W2007137792 hasRelatedWork W2014598994 @default.
• W2007137792 hasRelatedWork W2028240245 @default.
• W2007137792 hasRelatedWork W2106249539 @default.
• W2007137792 hasRelatedWork W2155020902 @default.
• W2007137792 hasRelatedWork W2240325685 @default.
• W2007137792 hasRelatedWork W2319327569 @default.
• W2007137792 hasRelatedWork W2418610178 @default.
• W2007137792 hasRelatedWork W2907502361 @default.
• W2007137792 hasRelatedWork W4239518401 @default.
• W2007137792 hasVolume "90" @default.
• W2007137792 isParatext "false" @default.
• W2007137792 isRetracted "false" @default.
• W2007137792 magId "2007137792" @default.
• W2007137792 workType "article" @default.