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• W2007139417 abstract "Summary Background Infections are an important concern in patients using immunosuppressive therapy for their inflammatory bowel disease ( IBD ). Diabetes affects nearly 10% of Americans. Whether it confers an additional risk with immunosuppression in IBD has not been examined previously. Aim To examine the association between diabetes and infections with immunomodulator use in IBD Methods Using a validated, multi‐institutional IBD cohort, we identified all patients who received at least one prescription for immunomodulators (thiopurines, methotrexate). Our primary outcome was infection within 1 year of the prescription of the immunomodulator. Multivariable logistic regression adjusting for relevant confounders was used to estimate the independent association with diabetes. Results Our study included 2766 patients receiving at least one prescription for immunomodulators among whom 210 (8%) developed an infection within 1 year. Patients who developed an infection were likely to be older, have more comorbidities, more likely to have received a prescription for steroids but similar in initiation of anti‐ TNF therapy within that year. Only 8% of those without an infection had diabetes compared to 19% of those who developed an infection within 1 year [odds ratio ( OR ) 2.74, 95% confidence interval ( CI ) 1.88–3.98, P < 0.001]. On multivariate analysis, diabetes was independently associated with a nearly two‐fold increase in risk of infections ( OR : 1.80, 95% CI : 1.20–2.68). There was no increase in risk of infections with addition of anti‐ TNF therapy ( OR : 1.14, 95% CI : 0.80–1.63). Conclusion Diabetes is an independent risk factor for infection in IBD patients using immunomodulator therapy." @default.
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• W2007139417 date "2015-04-13" @default.
• W2007139417 modified "2023-09-27" @default.
• W2007139417 title "Diabetes and the risk of infections with immunomodulator therapy in inflammatory bowel diseases" @default.
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• W2007139417 doi "https://doi.org/10.1111/apt.13195" @default.
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