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• W2007141352 abstract "To determine the influence of pol replication capacity on the natural history of HIV-1 infection.Pol replication capacity was measured using a recombinant virus single cycle assay on baseline plasma specimens from subjects enrolled in the Hemophilia Growth and Development Study.Children and adolescents with hemophilia and HIV-1 infection were enrolled at multiple sites across the USA into a natural history study.The Hemophilia Growth and Development Study enrolled 207 HIV-1-infected hemophiliacs between 6 and 19 years of age in 1989 and 1990. Subjects were followed every 6 months through 1997 with pol replication capacity measurements available from 128 of the subjects.A univariate model defined the relationship between pol replication capacity and HIV-1 RNA and CD4 T-cell number. A random effects model assessed the ability of this measure to predict CD4 T-cell decline over time and a Cox proportional hazards model and Kaplan-Meier analyses defined how it predicts clinical progression.Pol replication capacity measures correlated with baseline HIV-1 RNA, R = 0.189 (P = 0.03) and CD4 T-cell number, -0.197 (P = 0.03). It also independently predicted CD4 T-cell decline over time and progression to AIDS.This study demonstrates that pol replication capacity independently influences the natural history of HIV-1 infection." @default.
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• W2007141352 date "2005-06-10" @default.
• W2007141352 modified "2023-09-23" @default.
• W2007141352 title "HIV-1 pol replication capacity predicts disease progression" @default.
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• W2007141352 doi "https://doi.org/10.1097/01.aids.0000171400.15619.e1" @default.
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