FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007143460> ?p ?o ?g. }

• W2007143460 endingPage "1232" @default.
• W2007143460 startingPage "1221" @default.
• W2007143460 abstract "Expression of chimeras, composed of portions of two different glucose transporter isoforms (GLUT-1 and GLUT-4), in CHO cells had indicated that the cytoplasmic NH2 terminus of GLUT-4 contains important targeting information that mediates intracellular sequestration of this isoform (Piper, R. C., C. Tai, J. W. Slot, C. S. Hahn, C. M. Rice, H. Huang, D. E. James. 1992. J. Cell Biol. 117:729-743). In the present studies, the amino acid constituents of the GLUT-4 NH2-terminal targeting domain have been identified. GLUT-4 constructs containing NH2-terminal deletions or alanine substitutions within the NH2 terminus were expressed in CHO cells using a Sindbis virus expression system. Deletion of eight amino acids from the GLUT-4 NH2 terminus or substituting alanine for phenylalanine at position 5 in GLUT-4 resulted in a marked accumulation of the transporter at the plasma membrane. Mutations at other amino acids surrounding Phe5 also caused increased cell surface expression of GLUT-4 but not to the same extent as the Phe5 mutation. GLUT-4 was also localized to clathrin lattices and this colocalization was abolished when either the first 13 amino acids were deleted or when Phe5 was changed to alanine. To ascertain whether the targeting information within the GLUT-4 NH2-terminal targeting domain could function independently of the glucose transporter structure this domain was inserted into the cytoplasmic tail of the H1 subunit of the asialoglycoprotein receptor. H1 with the GLUT-4 NH2 terminus was predominantly localized to an intracellular compartment similar to GLUT-4 and was sequestered more from the cell surface than was the wild-type H1 protein. It is concluded that the NH2 terminus of GLUT-4 contains a phenylalanine-based targeting motif that mediates intracellular sequestration at least in part by facilitating interaction of the transporter with endocytic machinery located at the cell surface." @default.
• W2007143460 created "2016-06-24" @default.
• W2007143460 creator A5004382546 @default.
• W2007143460 creator A5012799071 @default.
• W2007143460 creator A5013347882 @default.
• W2007143460 creator A5025115770 @default.
• W2007143460 creator A5029458576 @default.
• W2007143460 creator A5035259090 @default.
• W2007143460 creator A5036903689 @default.
• W2007143460 creator A5056160223 @default.
• W2007143460 creator A5070945300 @default.
• W2007143460 creator A5080897795 @default.
• W2007143460 date "1993-06-15" @default.
• W2007143460 modified "2023-10-15" @default.
• W2007143460 title "GLUT-4 NH2 terminus contains a phenylalanine-based targeting motif that regulates intracellular sequestration." @default.
• W2007143460 cites W120166209 @default.
• W2007143460 cites W1483819615 @default.
• W2007143460 cites W1490846487 @default.
• W2007143460 cites W1493638086 @default.
• W2007143460 cites W1519083075 @default.
• W2007143460 cites W1526233070 @default.
• W2007143460 cites W1529141138 @default.
• W2007143460 cites W1556712517 @default.
• W2007143460 cites W1564186686 @default.
• W2007143460 cites W1583703772 @default.
• W2007143460 cites W1645373081 @default.
• W2007143460 cites W1874037893 @default.
• W2007143460 cites W1911305856 @default.
• W2007143460 cites W1972580189 @default.
• W2007143460 cites W1976177239 @default.
• W2007143460 cites W1977834451 @default.
• W2007143460 cites W1989424897 @default.
• W2007143460 cites W1991410135 @default.
• W2007143460 cites W1995696385 @default.
• W2007143460 cites W1997862023 @default.
• W2007143460 cites W2001736800 @default.
• W2007143460 cites W2018364757 @default.
• W2007143460 cites W2044343226 @default.
• W2007143460 cites W2059031237 @default.
• W2007143460 cites W2061462231 @default.
• W2007143460 cites W2065009864 @default.
• W2007143460 cites W2067691363 @default.
• W2007143460 cites W2070892520 @default.
• W2007143460 cites W2074045232 @default.
• W2007143460 cites W2074783201 @default.
• W2007143460 cites W2080066315 @default.
• W2007143460 cites W2080828698 @default.
• W2007143460 cites W2082861222 @default.
• W2007143460 cites W2109223015 @default.
• W2007143460 cites W2115569175 @default.
• W2007143460 cites W2126564161 @default.
• W2007143460 cites W2128840474 @default.
• W2007143460 cites W2138270253 @default.
• W2007143460 cites W2150207458 @default.
• W2007143460 cites W2156126895 @default.
• W2007143460 cites W2328895879 @default.
• W2007143460 cites W2408312165 @default.
• W2007143460 cites W48961390 @default.
• W2007143460 cites W69372474 @default.
• W2007143460 cites W70275427 @default.
• W2007143460 doi "https://doi.org/10.1083/jcb.121.6.1221" @default.
• W2007143460 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2119717" @default.
• W2007143460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8509445" @default.
• W2007143460 hasPublicationYear "1993" @default.
• W2007143460 type Work @default.
• W2007143460 sameAs 2007143460 @default.
• W2007143460 citedByCount "117" @default.
• W2007143460 countsByYear W20071434602012 @default.
• W2007143460 countsByYear W20071434602013 @default.
• W2007143460 countsByYear W20071434602014 @default.
• W2007143460 countsByYear W20071434602015 @default.
• W2007143460 countsByYear W20071434602016 @default.
• W2007143460 countsByYear W20071434602017 @default.
• W2007143460 countsByYear W20071434602020 @default.
• W2007143460 countsByYear W20071434602021 @default.
• W2007143460 crossrefType "journal-article" @default.
• W2007143460 hasAuthorship W2007143460A5004382546 @default.
• W2007143460 hasAuthorship W2007143460A5012799071 @default.
• W2007143460 hasAuthorship W2007143460A5013347882 @default.
• W2007143460 hasAuthorship W2007143460A5025115770 @default.
• W2007143460 hasAuthorship W2007143460A5029458576 @default.
• W2007143460 hasAuthorship W2007143460A5035259090 @default.
• W2007143460 hasAuthorship W2007143460A5036903689 @default.
• W2007143460 hasAuthorship W2007143460A5056160223 @default.
• W2007143460 hasAuthorship W2007143460A5070945300 @default.
• W2007143460 hasAuthorship W2007143460A5080897795 @default.
• W2007143460 hasBestOaLocation W20071434601 @default.
• W2007143460 hasConcept C104317684 @default.
• W2007143460 hasConcept C118892022 @default.
• W2007143460 hasConcept C120405084 @default.
• W2007143460 hasConcept C134018914 @default.
• W2007143460 hasConcept C14053116 @default.
• W2007143460 hasConcept C149011108 @default.
• W2007143460 hasConcept C153911025 @default.
• W2007143460 hasConcept C161573976 @default.
• W2007143460 hasConcept C167625842 @default.
• W2007143460 hasConcept C170493617 @default.
• W2007143460 hasConcept C175656101 @default.

• next