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- W2007148923 abstract "Antibodies directed against carbohydrate determinants provide useful model systems for understanding the structure and organisation of antibody genes and the generation of antibody diversity. We have used three such systems, PC, DEX and GAC, and have studied the heavy chains and V H gene segments of each. In two of these systems, PC and GAC, much of the diversity in heavy-chain protein sequences results from somatic mutation events superimposed on expression of a single V H gene. In the DEX system, it appears that germ-line sequence diversity may be an important contributor to the variability in heavy-chain sequence. Detailed structural analyses of this type will ultimately provide a complete picture of the mechanisms which underlie effective humoral immunity. Les résultats obtenus au cours de l'analyse structurale de gènes V H codant pour des anticorps dirigés contre des déterminants sucrés (DEX, PC, GAC) soulignent l'importance des mutations somatiques dans la génération de la diversité des anticorps. Cependant, le haut degré de conservation de ces gènes V H parmi différentes souches de souris et différentes espèces implique que ces gènes sont soumis à de fortes pressions de sélection." @default.
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- W2007148923 date "1984-01-01" @default.
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- W2007148923 title "Molecular genetics of anti-carbohydrate antibodies" @default.
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- W2007148923 doi "https://doi.org/10.1016/s0769-2625(84)80016-1" @default.
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