FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007153971> ?p ?o ?g. }

• W2007153971 endingPage "72" @default.
• W2007153971 startingPage "59" @default.
• W2007153971 abstract "Clusters of regularly spaced direct repeats, separated by unconserved spacer sequences, are ubiquitous in archaeal chromosomes and occur in some plasmids. Some clusters constitute around 1% of chromosomal DNA. Similarly structured clusters, generally smaller, also occur in some bacterial chromosomes. Although early studies implicated these clusters in segregation/partition functions, recent evidence suggests that the spacer sequences derive from extrachromosomal elements, and, primarily, viruses. This has led to the proposal that the clusters provide a defence against viral propagation in cells, and that both the mode of inhibition of viral propagation and the mechanism of adding spacer-repeat units to clusters, are dependent on RNAs transcribed from the clusters. Moreover, the putative inhibitory apparatus (piRNA-based) may be evolutionarily related to the interference RNA systems (siRNA and miRNA), which are common in eukarya. Here, we analyze all the current data on archaeal repeat clusters and provide some new insights into their diverse structures, transcriptional properties and mode of structural development. The results are consistent with larger cluster transcripts being processed at the centers of the repeat sequences and being further trimmed by exonucleases to yield a dominant, intracellular RNA species, which corresponds approximately to the size of a spacer. Furthermore, analysis of the extensive clusters of Sulfolobus solfataricus strains P1 and P2B provides support for the presence of a flanking sequence adjoining a cluster being a prerequisite for the incorporation of new spacer-repeat units, which occurs between the flanking sequence and the cluster. An archaeal database summarizing the data will be maintained at http://dac.molbio.ku.dk/dbs/SRSR/." @default.
• W2007153971 created "2016-06-24" @default.
• W2007153971 creator A5004899986 @default.
• W2007153971 creator A5039521123 @default.
• W2007153971 creator A5058594816 @default.
• W2007153971 creator A5086906059 @default.
• W2007153971 date "2006-01-01" @default.
• W2007153971 modified "2023-10-16" @default.
• W2007153971 title "A putative viral defence mechanism in archaeal cells" @default.
• W2007153971 cites W1983403577 @default.
• W2007153971 cites W1986171241 @default.
• W2007153971 cites W1987154973 @default.
• W2007153971 cites W1988254951 @default.
• W2007153971 cites W1990487336 @default.
• W2007153971 cites W1994277771 @default.
• W2007153971 cites W1995168829 @default.
• W2007153971 cites W1995867192 @default.
• W2007153971 cites W1997143556 @default.
• W2007153971 cites W1998830497 @default.
• W2007153971 cites W2001396957 @default.
• W2007153971 cites W2013595954 @default.
• W2007153971 cites W2015794762 @default.
• W2007153971 cites W2027736602 @default.
• W2007153971 cites W2029647341 @default.
• W2007153971 cites W2042673746 @default.
• W2007153971 cites W2067853474 @default.
• W2007153971 cites W2074106269 @default.
• W2007153971 cites W2077190448 @default.
• W2007153971 cites W2087583350 @default.
• W2007153971 cites W2090438401 @default.
• W2007153971 cites W2091278469 @default.
• W2007153971 cites W2091760726 @default.
• W2007153971 cites W2098424996 @default.
• W2007153971 cites W2110612352 @default.
• W2007153971 cites W2118746294 @default.
• W2007153971 cites W2119481297 @default.
• W2007153971 cites W2123965484 @default.
• W2007153971 cites W2136263210 @default.
• W2007153971 cites W2139544568 @default.
• W2007153971 cites W2139548670 @default.
• W2007153971 cites W2139762065 @default.
• W2007153971 cites W2139841981 @default.
• W2007153971 cites W2144631869 @default.
• W2007153971 cites W2147531155 @default.
• W2007153971 cites W2153355254 @default.
• W2007153971 cites W2162900837 @default.
• W2007153971 cites W2162912294 @default.
• W2007153971 cites W2166139447 @default.
• W2007153971 cites W2171445712 @default.
• W2007153971 doi "https://doi.org/10.1155/2006/542818" @default.
• W2007153971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2685585" @default.
• W2007153971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16877322" @default.
• W2007153971 hasPublicationYear "2006" @default.
• W2007153971 type Work @default.
• W2007153971 sameAs 2007153971 @default.
• W2007153971 citedByCount "234" @default.
• W2007153971 countsByYear W20071539712012 @default.
• W2007153971 countsByYear W20071539712013 @default.
• W2007153971 countsByYear W20071539712014 @default.
• W2007153971 countsByYear W20071539712015 @default.
• W2007153971 countsByYear W20071539712016 @default.
• W2007153971 countsByYear W20071539712017 @default.
• W2007153971 countsByYear W20071539712018 @default.
• W2007153971 countsByYear W20071539712019 @default.
• W2007153971 countsByYear W20071539712020 @default.
• W2007153971 countsByYear W20071539712021 @default.
• W2007153971 countsByYear W20071539712022 @default.
• W2007153971 crossrefType "journal-article" @default.
• W2007153971 hasAuthorship W2007153971A5004899986 @default.
• W2007153971 hasAuthorship W2007153971A5039521123 @default.
• W2007153971 hasAuthorship W2007153971A5058594816 @default.
• W2007153971 hasAuthorship W2007153971A5086906059 @default.
• W2007153971 hasBestOaLocation W20071539711 @default.
• W2007153971 hasConcept C104317684 @default.
• W2007153971 hasConcept C141231307 @default.
• W2007153971 hasConcept C22744801 @default.
• W2007153971 hasConcept C2778644216 @default.
• W2007153971 hasConcept C2780631447 @default.
• W2007153971 hasConcept C29511175 @default.
• W2007153971 hasConcept C54355233 @default.
• W2007153971 hasConcept C550995028 @default.
• W2007153971 hasConcept C552990157 @default.
• W2007153971 hasConcept C67705224 @default.
• W2007153971 hasConcept C70721500 @default.
• W2007153971 hasConcept C86803240 @default.
• W2007153971 hasConcept C89684784 @default.
• W2007153971 hasConceptScore W2007153971C104317684 @default.
• W2007153971 hasConceptScore W2007153971C141231307 @default.
• W2007153971 hasConceptScore W2007153971C22744801 @default.
• W2007153971 hasConceptScore W2007153971C2778644216 @default.
• W2007153971 hasConceptScore W2007153971C2780631447 @default.
• W2007153971 hasConceptScore W2007153971C29511175 @default.
• W2007153971 hasConceptScore W2007153971C54355233 @default.
• W2007153971 hasConceptScore W2007153971C550995028 @default.
• W2007153971 hasConceptScore W2007153971C552990157 @default.
• W2007153971 hasConceptScore W2007153971C67705224 @default.
• W2007153971 hasConceptScore W2007153971C70721500 @default.
• W2007153971 hasConceptScore W2007153971C86803240 @default.

• next