FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007155094> ?p ?o ?g. }

• W2007155094 endingPage "1714" @default.
• W2007155094 startingPage "1703" @default.
• W2007155094 abstract "Previous reports showed that embryonic stem (ES) cells contain hyperdynamic and globally transcribed chromatin-properties that are important for ES cell pluripotency and differentiation. Here, we demonstrate a role for undifferentiated embryonic cell transcription factor 1 (UTF1) in regulating ES cell chromatin structure. Using chromatin immunoprecipitation-on-chip analysis, we identified >1,700 UTF1 target genes that significantly overlap with previously identified Nanog, Oct4, Klf-4, c-Myc, and Rex1 targets. Gene expression profiling showed that UTF1 knock down results in increased expression of a large set of genes, including a significant number of UTF1 targets. UTF1 knock down (KD) ES cells are, irrespective of the increased expression of several self-renewal genes, Leukemia inhibitory factor (LIF) dependent. However, UTF1 KD ES cells are perturbed in their differentiation in response to dimethyl sulfoxide (DMSO) or after LIF withdrawal and display increased colony formation. UTF1 KD ES cells display extensive chromatin decondensation, reflected by a dramatic increase in nucleosome release on micrococcal nuclease (MNase) treatment and enhanced MNase sensitivity of UTF1 target genes in UTF1 KD ES cells. Summarizing, our data show that UTF1 is a key chromatin component in ES cells, preventing ES cell chromatin decondensation, and aberrant gene expression; both essential for proper initiation of lineage-specific differentiation of ES cells." @default.
• W2007155094 created "2016-06-24" @default.
• W2007155094 creator A5001840276 @default.
• W2007155094 creator A5011527043 @default.
• W2007155094 creator A5013678424 @default.
• W2007155094 creator A5025350377 @default.
• W2007155094 creator A5029380319 @default.
• W2007155094 creator A5030515369 @default.
• W2007155094 creator A5041265540 @default.
• W2007155094 creator A5045055598 @default.
• W2007155094 creator A5065057686 @default.
• W2007155094 creator A5077753928 @default.
• W2007155094 creator A5085047665 @default.
• W2007155094 creator A5088229553 @default.
• W2007155094 date "2010-10-01" @default.
• W2007155094 modified "2023-10-16" @default.
• W2007155094 title "Undifferentiated Embryonic Cell Transcription Factor 1 Regulates ESC Chromatin Organization and Gene Expression " @default.
• W2007155094 cites W111471919 @default.
• W2007155094 cites W1676204041 @default.
• W2007155094 cites W1951165114 @default.
• W2007155094 cites W1965428318 @default.
• W2007155094 cites W1968931043 @default.
• W2007155094 cites W1975200987 @default.
• W2007155094 cites W1979245454 @default.
• W2007155094 cites W1982650546 @default.
• W2007155094 cites W1990605347 @default.
• W2007155094 cites W1991667131 @default.
• W2007155094 cites W1995547197 @default.
• W2007155094 cites W2005601940 @default.
• W2007155094 cites W2019113978 @default.
• W2007155094 cites W2035421116 @default.
• W2007155094 cites W2042283473 @default.
• W2007155094 cites W2046241907 @default.
• W2007155094 cites W2053378592 @default.
• W2007155094 cites W2057069431 @default.
• W2007155094 cites W2067249190 @default.
• W2007155094 cites W2076676430 @default.
• W2007155094 cites W2079599988 @default.
• W2007155094 cites W2084774342 @default.
• W2007155094 cites W2086556990 @default.
• W2007155094 cites W2088877376 @default.
• W2007155094 cites W2096083625 @default.
• W2007155094 cites W2098549100 @default.
• W2007155094 cites W2102140165 @default.
• W2007155094 cites W2103660187 @default.
• W2007155094 cites W2104183138 @default.
• W2007155094 cites W2107024719 @default.
• W2007155094 cites W2107277218 @default.
• W2007155094 cites W2109744103 @default.
• W2007155094 cites W2110015307 @default.
• W2007155094 cites W2116228913 @default.
• W2007155094 cites W2120865735 @default.
• W2007155094 cites W2122215608 @default.
• W2007155094 cites W2125734502 @default.
• W2007155094 cites W2126376889 @default.
• W2007155094 cites W2126731419 @default.
• W2007155094 cites W2127595444 @default.
• W2007155094 cites W2136438175 @default.
• W2007155094 cites W2137650223 @default.
• W2007155094 cites W2139594740 @default.
• W2007155094 cites W2145091349 @default.
• W2007155094 cites W2149790281 @default.
• W2007155094 cites W2157896232 @default.
• W2007155094 cites W2159675211 @default.
• W2007155094 cites W2161224111 @default.
• W2007155094 cites W2163260113 @default.
• W2007155094 cites W2167755634 @default.
• W2007155094 cites W2171030481 @default.
• W2007155094 doi "https://doi.org/10.1002/stem.497" @default.
• W2007155094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20715181" @default.
• W2007155094 hasPublicationYear "2010" @default.
• W2007155094 type Work @default.
• W2007155094 sameAs 2007155094 @default.
• W2007155094 citedByCount "31" @default.
• W2007155094 countsByYear W20071550942012 @default.
• W2007155094 countsByYear W20071550942013 @default.
• W2007155094 countsByYear W20071550942014 @default.
• W2007155094 countsByYear W20071550942015 @default.
• W2007155094 countsByYear W20071550942017 @default.
• W2007155094 countsByYear W20071550942018 @default.
• W2007155094 countsByYear W20071550942019 @default.
• W2007155094 countsByYear W20071550942021 @default.
• W2007155094 countsByYear W20071550942022 @default.
• W2007155094 countsByYear W20071550942023 @default.
• W2007155094 crossrefType "journal-article" @default.
• W2007155094 hasAuthorship W2007155094A5001840276 @default.
• W2007155094 hasAuthorship W2007155094A5011527043 @default.
• W2007155094 hasAuthorship W2007155094A5013678424 @default.
• W2007155094 hasAuthorship W2007155094A5025350377 @default.
• W2007155094 hasAuthorship W2007155094A5029380319 @default.
• W2007155094 hasAuthorship W2007155094A5030515369 @default.
• W2007155094 hasAuthorship W2007155094A5041265540 @default.
• W2007155094 hasAuthorship W2007155094A5045055598 @default.
• W2007155094 hasAuthorship W2007155094A5065057686 @default.
• W2007155094 hasAuthorship W2007155094A5077753928 @default.
• W2007155094 hasAuthorship W2007155094A5085047665 @default.
• W2007155094 hasAuthorship W2007155094A5088229553 @default.
• W2007155094 hasBestOaLocation W20071550942 @default.

• next