FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007155819> ?p ?o ?g. }

• W2007155819 endingPage "1173" @default.
• W2007155819 startingPage "1161" @default.
• W2007155819 abstract "Pregnant mice were treated on gestation Day 11 (E11) with a single dose of either hydroxyurea (HU, 250 mg/kg) or 5-bromo-2′deoxyuridine (BrdU, 500 mg/kg), or with a combination of the two agents. The dams were either allowed to go to term, when the fetuses were examined for cleft palate (CP) and digital anomalies, or killed 24 hr after the treatment. In the latter case, limbs from the embryos of control and treated dams were excised and cultured for 6 days in submerged culture. At the end of the culture period, the limb explants were stained for cartilage. The various cartilaginous components were subsequently analyzed using image analysis methods. CP was observed in 2.4 and 22.9% of the fetuses, respectively, after a single dose of HU or BrdU on E11. Simultaneous HU + BrdU treatment decreased the incidence of BrdU-induced CP to 3.6%, while treatment with BrdU 3 hr after HU resulted in 33.3% CP. In addition, syndactyly and ectrodactyly, not seen after the treatment with either HU or BrdU alone, were observed when the two agents were administered simultaneously, 1 hr apart or with a 3-hr delay. The teratogenic response was enhanced when limbs were cultured for 6 days. Digital anomalies were observed in the limb explants of BrdU-pretreated embryos; such abnormalities were not observed in vivo. Image analysis of cultured limb explants revealed that with HU-3 hr-BrdU pretreatment, the total limb area occupied by the long bones was increased at the cost of the paw area. However, no consistent changes in the shape or form of individual bones were observed. HU and BrdU given together produced a teratogenic response which was significantly different from that observed following the administration of HU or BrdU alone. This is considered to be due to an interference with the incorporation of BrdU in the DNA, since HU is known to block DNA synthesis. When HU was given before BrdU, the effects of BrdU were enhanced, probably due to the reported synchronizing action of HU on dividing cells. We also found that after a similar in utero exposure, the culture conditions themselves enhanced the frequency of teratogenic expression of BrdU." @default.
• W2007155819 created "2016-06-24" @default.
• W2007155819 creator A5004311307 @default.
• W2007155819 creator A5019605717 @default.
• W2007155819 date "1985-12-01" @default.
• W2007155819 modified "2023-09-27" @default.
• W2007155819 title "The teratogenic interaction of hydroxyurea and 5-bromodeoxyuridine examined with the aid of limb culture and image analysis" @default.
• W2007155819 cites W1499685167 @default.
• W2007155819 cites W1522572396 @default.
• W2007155819 cites W1538415171 @default.
• W2007155819 cites W1570287471 @default.
• W2007155819 cites W1581861423 @default.
• W2007155819 cites W164699645 @default.
• W2007155819 cites W1786079505 @default.
• W2007155819 cites W1842717210 @default.
• W2007155819 cites W1853222700 @default.
• W2007155819 cites W1965940222 @default.
• W2007155819 cites W1966377689 @default.
• W2007155819 cites W1977211897 @default.
• W2007155819 cites W1985334107 @default.
• W2007155819 cites W1998380199 @default.
• W2007155819 cites W1999159729 @default.
• W2007155819 cites W2003926268 @default.
• W2007155819 cites W2004981320 @default.
• W2007155819 cites W2015285381 @default.
• W2007155819 cites W2018468875 @default.
• W2007155819 cites W2027472570 @default.
• W2007155819 cites W2027588915 @default.
• W2007155819 cites W2040540541 @default.
• W2007155819 cites W2049473963 @default.
• W2007155819 cites W2052831612 @default.
• W2007155819 cites W2053597754 @default.
• W2007155819 cites W2060330821 @default.
• W2007155819 cites W2067635345 @default.
• W2007155819 cites W2079542552 @default.
• W2007155819 cites W2083149447 @default.
• W2007155819 cites W2104073051 @default.
• W2007155819 cites W2129020002 @default.
• W2007155819 cites W2139853293 @default.
• W2007155819 cites W2142332558 @default.
• W2007155819 cites W2157366010 @default.
• W2007155819 cites W2158138027 @default.
• W2007155819 cites W2158357173 @default.
• W2007155819 cites W2346591016 @default.
• W2007155819 cites W2429547184 @default.
• W2007155819 cites W2430687825 @default.
• W2007155819 cites W2991918749 @default.
• W2007155819 cites W65186055 @default.
• W2007155819 doi "https://doi.org/10.1016/0272-0590(85)90153-8" @default.
• W2007155819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4092878" @default.
• W2007155819 hasPublicationYear "1985" @default.
• W2007155819 type Work @default.
• W2007155819 sameAs 2007155819 @default.
• W2007155819 citedByCount "7" @default.
• W2007155819 crossrefType "journal-article" @default.
• W2007155819 hasAuthorship W2007155819A5004311307 @default.
• W2007155819 hasAuthorship W2007155819A5019605717 @default.
• W2007155819 hasConcept C105702510 @default.
• W2007155819 hasConcept C126322002 @default.
• W2007155819 hasConcept C157890192 @default.
• W2007155819 hasConcept C16685009 @default.
• W2007155819 hasConcept C172680121 @default.
• W2007155819 hasConcept C196843134 @default.
• W2007155819 hasConcept C202751555 @default.
• W2007155819 hasConcept C204232928 @default.
• W2007155819 hasConcept C2776790153 @default.
• W2007155819 hasConcept C2777202849 @default.
• W2007155819 hasConcept C2777304866 @default.
• W2007155819 hasConcept C2778260397 @default.
• W2007155819 hasConcept C2779234561 @default.
• W2007155819 hasConcept C46973012 @default.
• W2007155819 hasConcept C54355233 @default.
• W2007155819 hasConcept C55493867 @default.
• W2007155819 hasConcept C65290608 @default.
• W2007155819 hasConcept C71924100 @default.
• W2007155819 hasConcept C86803240 @default.
• W2007155819 hasConcept C95444343 @default.
• W2007155819 hasConceptScore W2007155819C105702510 @default.
• W2007155819 hasConceptScore W2007155819C126322002 @default.
• W2007155819 hasConceptScore W2007155819C157890192 @default.
• W2007155819 hasConceptScore W2007155819C16685009 @default.
• W2007155819 hasConceptScore W2007155819C172680121 @default.
• W2007155819 hasConceptScore W2007155819C196843134 @default.
• W2007155819 hasConceptScore W2007155819C202751555 @default.
• W2007155819 hasConceptScore W2007155819C204232928 @default.
• W2007155819 hasConceptScore W2007155819C2776790153 @default.
• W2007155819 hasConceptScore W2007155819C2777202849 @default.
• W2007155819 hasConceptScore W2007155819C2777304866 @default.
• W2007155819 hasConceptScore W2007155819C2778260397 @default.
• W2007155819 hasConceptScore W2007155819C2779234561 @default.
• W2007155819 hasConceptScore W2007155819C46973012 @default.
• W2007155819 hasConceptScore W2007155819C54355233 @default.
• W2007155819 hasConceptScore W2007155819C55493867 @default.
• W2007155819 hasConceptScore W2007155819C65290608 @default.
• W2007155819 hasConceptScore W2007155819C71924100 @default.
• W2007155819 hasConceptScore W2007155819C86803240 @default.
• W2007155819 hasConceptScore W2007155819C95444343 @default.
• W2007155819 hasIssue "6" @default.

• next