Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007157228> ?p ?o ?g. }
- W2007157228 endingPage "422" @default.
- W2007157228 startingPage "411" @default.
- W2007157228 abstract "We determined the role of glucocorticoids in the maturation of glycoprotein galactosylation and fucosylation processes in the rat small intestine during postnatal development. Treatment of suckling rats with hydrocortisone (HC) increased activities of an O-glycan: galactosyltransferase, and of an alpha-1,2-fucosyltransferase, through transcriptional regulation of the FTB gene. The activities of a fucosyltransferase inhibitor and of the enzymes responsible for the synthesis and degradation of GDP-fucose were unaffected by the treatment, whereas a fall in the activity of alpha-L-fucosidase was observed. These changes were accompanied by the precocious appearance of alpha-1,2-fucose residues in complex glycan chains of brush-border membrane glycoproteins that normally appear after weaning, and with a trend to increase in alpha-1,2-fucose residues in mucins. Thus, treatment of suckling rats with hydrocortisone speeds up the maturation of glycoprotein galactosylation and fucosylation processes in the small intestine. The delayed increase in glucocorticoid levels induced by prolonged nursing, or the suppression of glucocorticoids by adrenalectomy (AD) before the normal rise in the hormone, both induced a delay in the increases in activities of the O-glycan: galactosyltransferase and alpha-1,2-fucosyltransferase observed normally after glucocorticoid enhancement. Thus, glucocorticoids might play at least a partial role in the maturation of glycoprotein glycosylation observed at weaning." @default.
- W2007157228 created "2016-06-24" @default.
- W2007157228 creator A5004683587 @default.
- W2007157228 creator A5028654992 @default.
- W2007157228 creator A5028686214 @default.
- W2007157228 creator A5076935552 @default.
- W2007157228 date "2003-03-01" @default.
- W2007157228 modified "2023-09-25" @default.
- W2007157228 title "Glucocorticoid-induced maturation of glycoprotein galactosylation and fucosylation processes in the rat small intestine" @default.
- W2007157228 cites W1502595232 @default.
- W2007157228 cites W1552033470 @default.
- W2007157228 cites W1566625109 @default.
- W2007157228 cites W1768014103 @default.
- W2007157228 cites W1775749144 @default.
- W2007157228 cites W1798589712 @default.
- W2007157228 cites W1801703436 @default.
- W2007157228 cites W1815465219 @default.
- W2007157228 cites W1964446466 @default.
- W2007157228 cites W1997110219 @default.
- W2007157228 cites W2002539888 @default.
- W2007157228 cites W2007549883 @default.
- W2007157228 cites W2013720344 @default.
- W2007157228 cites W2015842597 @default.
- W2007157228 cites W2017941437 @default.
- W2007157228 cites W2025439114 @default.
- W2007157228 cites W2029056840 @default.
- W2007157228 cites W2031048120 @default.
- W2007157228 cites W2039031929 @default.
- W2007157228 cites W2041052264 @default.
- W2007157228 cites W2045657134 @default.
- W2007157228 cites W2045697259 @default.
- W2007157228 cites W2046616083 @default.
- W2007157228 cites W2057397934 @default.
- W2007157228 cites W2058057491 @default.
- W2007157228 cites W2062878348 @default.
- W2007157228 cites W2066278775 @default.
- W2007157228 cites W2069074603 @default.
- W2007157228 cites W2080483966 @default.
- W2007157228 cites W2081761323 @default.
- W2007157228 cites W2082497364 @default.
- W2007157228 cites W2084348808 @default.
- W2007157228 cites W2087767309 @default.
- W2007157228 cites W2088437080 @default.
- W2007157228 cites W2093367828 @default.
- W2007157228 cites W2096356941 @default.
- W2007157228 cites W2108407399 @default.
- W2007157228 cites W2120066124 @default.
- W2007157228 cites W2280741419 @default.
- W2007157228 cites W2283256024 @default.
- W2007157228 cites W2412879644 @default.
- W2007157228 cites W2413967915 @default.
- W2007157228 cites W2414395870 @default.
- W2007157228 cites W4294216491 @default.
- W2007157228 cites W88725230 @default.
- W2007157228 cites W965074945 @default.
- W2007157228 doi "https://doi.org/10.1016/s0960-0760(03)00062-1" @default.
- W2007157228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12732286" @default.
- W2007157228 hasPublicationYear "2003" @default.
- W2007157228 type Work @default.
- W2007157228 sameAs 2007157228 @default.
- W2007157228 citedByCount "19" @default.
- W2007157228 countsByYear W20071572282015 @default.
- W2007157228 countsByYear W20071572282016 @default.
- W2007157228 countsByYear W20071572282017 @default.
- W2007157228 countsByYear W20071572282022 @default.
- W2007157228 countsByYear W20071572282023 @default.
- W2007157228 crossrefType "journal-article" @default.
- W2007157228 hasAuthorship W2007157228A5004683587 @default.
- W2007157228 hasAuthorship W2007157228A5028654992 @default.
- W2007157228 hasAuthorship W2007157228A5028686214 @default.
- W2007157228 hasAuthorship W2007157228A5076935552 @default.
- W2007157228 hasConcept C108625454 @default.
- W2007157228 hasConcept C126322002 @default.
- W2007157228 hasConcept C134018914 @default.
- W2007157228 hasConcept C181199279 @default.
- W2007157228 hasConcept C185592680 @default.
- W2007157228 hasConcept C2776841590 @default.
- W2007157228 hasConcept C2777313579 @default.
- W2007157228 hasConcept C2777762822 @default.
- W2007157228 hasConcept C2779212266 @default.
- W2007157228 hasConcept C2780302934 @default.
- W2007157228 hasConcept C2780841215 @default.
- W2007157228 hasConcept C2780895608 @default.
- W2007157228 hasConcept C55493867 @default.
- W2007157228 hasConcept C71924100 @default.
- W2007157228 hasConcept C86803240 @default.
- W2007157228 hasConceptScore W2007157228C108625454 @default.
- W2007157228 hasConceptScore W2007157228C126322002 @default.
- W2007157228 hasConceptScore W2007157228C134018914 @default.
- W2007157228 hasConceptScore W2007157228C181199279 @default.
- W2007157228 hasConceptScore W2007157228C185592680 @default.
- W2007157228 hasConceptScore W2007157228C2776841590 @default.
- W2007157228 hasConceptScore W2007157228C2777313579 @default.
- W2007157228 hasConceptScore W2007157228C2777762822 @default.
- W2007157228 hasConceptScore W2007157228C2779212266 @default.
- W2007157228 hasConceptScore W2007157228C2780302934 @default.
- W2007157228 hasConceptScore W2007157228C2780841215 @default.
- W2007157228 hasConceptScore W2007157228C2780895608 @default.