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- W2007162433 endingPage "2704" @default.
- W2007162433 startingPage "2691" @default.
- W2007162433 abstract "The superior paraolivary nucleus (SPON) is a prominent cell group in the auditory brain stem that has been increasingly implicated in representing temporal sound structure. Although SPON neurons selectively respond to acoustic signals important for sound periodicity, the underlying physiological specializations enabling these responses are poorly understood. We used in vitro and in vivo recordings to investigate how SPON neurons develop intrinsic cellular properties that make them well suited for encoding temporal sound features. In addition to their hallmark rebound spiking at the stimulus offset, SPON neurons were characterized by spiking patterns termed onset, adapting, and burst in response to depolarizing stimuli in vitro. Cells with burst spiking had some morphological differences compared with other SPON neurons and were localized to the dorsolateral region of the nucleus. Both membrane and spiking properties underwent strong developmental regulation, becoming more temporally precise with age for both onset and offset spiking. Single-unit recordings obtained in young mice demonstrated that SPON neurons respond with temporally precise onset spiking upon tone stimulation in vivo, in addition to the typical offset spiking. Taken together, the results of the present study demonstrate that SPON neurons develop sharp on-off spiking, which may confer sensitivity to sound amplitude modulations or abrupt sound transients. These findings are consistent with the proposed involvement of the SPON in the processing of temporal sound structure, relevant for encoding communication cues." @default.
- W2007162433 created "2016-06-24" @default.
- W2007162433 creator A5015286680 @default.
- W2007162433 creator A5034181526 @default.
- W2007162433 creator A5047854777 @default.
- W2007162433 creator A5054848468 @default.
- W2007162433 date "2013-06-01" @default.
- W2007162433 modified "2023-09-30" @default.
- W2007162433 title "Development of on-off spiking in superior paraolivary nucleus neurons of the mouse" @default.
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