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- W2007170015 abstract "Three groups of choline-deficient (c.d.) and choline-supplemented (c.s.) rats were fed, respectively, a fat-free, a moderate (7%), or a high-fat (31.5%) diet for 3 days. Further groups of c.d. and c.s. rats on the 7% fat diet were killed at intervals of 2, 3, 4, 5, 8, 11, and 15 days. (1) The c.d. rats on the 7% and 31.5% fat diets developed fatty livers. (2) The activities in the liver of the enzymes related to lipogenesis were increased slightly in the initial stages in c.d. rats fed the 7% fat diet over their c.s. controls; but, by the end of 15 days the mean activities of the enyzmes were greater in the c.s. controls, indicating a diminished response of the c.d. livers to dietary challenges. (3) The hepatic levels of total adenine nucleotides and ATP were lower in the c.d. than in the c.s. rats fed the 7% and 31.5% fat diets. Increasing the levels of adenine nucleotides and ATP by feeding adenine sulfate did not prevent fatty liver in the c.d. rats fed a 7% fat diet. (4) Fatty acid oxidation, as assessed indirectly by the cytoplasmic NADH/NAD ratios and levels of β-hydroxybutyrate, was not impaired in the c.d. rats compared to the c.s. controls on diets containing 7% and 31.5% fat." @default.
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- W2007170015 date "1969-10-01" @default.
- W2007170015 modified "2023-09-27" @default.
- W2007170015 title "Mode of action of choline. IV. Activity of the enzymes related to fatty acid synthesis and the levels of metabolic intermediates in choline-deficient rats" @default.
- W2007170015 doi "https://doi.org/10.1139/o69-144" @default.
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