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• W2007173004 abstract "A detailed phytochemical study of the n-BuOH-soluble fraction of the 95% EtOH extract of red yeast rice fermented with the fungus Monascus pilosus BCRC 38072 (Eurotiaceae) revealed a new azaphilone derivative, namely monascusazaphilol (1) (rel-(3S,3aR,9aR)-3-(1-hydroxydecyl)-9a-methyl-6-((E)-propenyl)-3a,4,8,9a-tetrahydro-3H-furo[3,2-g]isochromene-2,9-dione), along with ten known compounds (2–11). Their structures were established by direct interpretation of their spectral data, mainly high resolution electrospray ionization mass spectrometry (HR-ESI-MS), 1D and 2D NMR (COSY, ROESY, HSQC and HMBC), and comparison of the spectroscopic data with those reported for structurally related compounds. We also evaluated the inhibitory effects of some isolates on the production of tumor necrosis factor (TNF-α) induced by lipopolysaccharide (LPS). Among the isolates, compounds 1–3 inhibited TNF-α production in U937 cells in vitro, and the IC50 values were 1.24, 2.35 and 3.75 μg/ml, respectively." @default.
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• W2007173004 date "2012-09-01" @default.
• W2007173004 modified "2023-10-05" @default.
• W2007173004 title "Secondary metabolites produced by the fungus Monascus pilosus and their anti-inflammatory activity" @default.
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• W2007173004 doi "https://doi.org/10.1016/j.phytol.2012.05.015" @default.
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